Synthesis and structure-activity relationships of tyrosine-based inhibitors of autotaxin (ATX)

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 23, 2010, Pages 7132-7136

  East, James E ^a   Kennedy, Andrew J ^a   Tomsig, Jose L ^b   De Leon, Alexandra R ^b   Lynch, Kevin R ^b   MacDonald, Timothy L ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Autotaxin; Hansch linear free energy relationship; Lysophosphatidic acid; Structure activity relationships

Indexed keywords

ANTINEOPLASTIC AGENT; AUTOTAXIN; BETA HYDROXYPHOSPHONATE; ENZYME INHIBITOR; HA 130; HA 51; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHOLIPASE; LYSOPHOSPHOLIPASE D; PHOSPHONIC ACID DERIVATIVE; PYRIDINE; S 32826; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG; VPC 8A 202;

ARTICLE; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; MOLECULAR DOCKING; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; ENZYME INHIBITORS; HUMANS; LYSOPHOSPHOLIPIDS; MULTIENZYME COMPLEXES; PHOSPHODIESTERASE I; PHOSPHORIC DIESTER HYDROLASES; PYRIDINES; PYROPHOSPHATASES; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

EID: 78149280469     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.09.030     Document Type: Article

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