Disperse distribution of cationic amino acids on hydrophilic surface of helical wheel enhances antimicrobial peptide activity

Biotechnology and Bioengineering

Volumn 107, Issue 2, 2010, Pages 216-223

  Kim, Young Soo ^a   Cha, Hyung Joon ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

Antimicrobial peptide; Cationic amino acid distribution; Structure activity relationship

Indexed keywords

AMINO ACID SEQUENCE; AMPHIPATHIC; ANTI-MICROBIAL ACTIVITY; ANTIMICROBIAL ACTION; ANTIMICROBIAL PEPTIDE; BACTERIAL MEMBRANES; CATIONIC AMINO ACIDS; CATIONIC DISTRIBUTION; DISPERSITY; DISTRIBUTION EFFECT; ELECTROSTATIC INTERACTIONS; HYDROPHILIC SURFACES; HYDROPHOBIC INTERACTIONS; HYDROPHOBIC RESIDUES; K-L MODEL; PORE FORMATION; RATIONAL REDESIGN; SINGLE VARIABLE; STRUCTURAL PARAMETER; STRUCTURE ACTIVITY RELATIONSHIPS;

DRUG INTERACTIONS; HYDROPHILICITY; HYDROPHOBICITY; MICROORGANISMS; PEPTIDES; POLYPEPTIDES; WHEELS; FACTOR ANALYSIS; MODULATION;

AMINO ACIDS;

AMINO ACID; CATION; LEUCINE; LYSINE; POLYPEPTIDE ANTIBIOTIC AGENT; ANTIMICROBIAL CATIONIC PEPTIDE;

AMINO ACID SEQUENCE; ANTIMICROBIAL ACTIVITY; ARTICLE; DRUG ACTIVITY; HYDROPHILICITY; HYDROPHOBICITY; MOUSE; NONHUMAN; PROTEIN LOCALIZATION; REGULATORY MECHANISM; STRUCTURE ACTIVITY RELATION; CHEMISTRY; CIRCULAR DICHROISM; PROTEIN SECONDARY STRUCTURE; ALPHA HELIX; BACTERIAL MEMBRANE; FLUORESCENCE RESONANCE ENERGY TRANSFER; PROTEIN STRUCTURE; REVIEW;

BACTERIA (MICROORGANISMS);

AMINO ACIDS; ANTIMICROBIAL CATIONIC PEPTIDES; CATIONS; CIRCULAR DICHROISM; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78149268666     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22810     Document Type: Article

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