메뉴 건너뛰기




Volumn 16, Issue SUPPL. 1, 2004, Pages

Mechanisms of action of PDE5 inhibition in erectile dysfunction

Author keywords

Cyclic GMP; Impotence; Penile erection; Phosphodiesterase inhibitors; Vasodilator agents

Indexed keywords

ARGININE; CYCLIC GMP; GUANYLATE CYCLASE; NITRIC OXIDE; PHOSPHODIESTERASE; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL;

EID: 3342962358     PISSN: 09559930     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijir.3901205     Document Type: Article
Times cited : (190)

References (17)
  • 1
    • 0030154874 scopus 로고    scopus 로고
    • Sildenafil: An orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction
    • Boolell M et al. Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res 1996; 8: 47-52.
    • (1996) Int J Impot Res , vol.8 , pp. 47-52
    • Boolell, M.1
  • 2
    • 0030438222 scopus 로고    scopus 로고
    • Sildenafil, a novel effective oral therapy for male erectile dysfunction
    • Boolell M, Gepi-Attee S, Gingell JC, Allen MJ. Sildenafil, a novel effective oral therapy for male erectile dysfunction. Br J Urol 1996; 78: 257-261.
    • (1996) Br J Urol , vol.78 , pp. 257-261
    • Boolell, M.1    Gepi-Attee, S.2    Gingell, J.C.3    Allen, M.J.4
  • 3
    • 0026353632 scopus 로고
    • Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission
    • Rajfer J et al. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med 1992; 326: 90-94.
    • (1992) N Engl J Med , vol.326 , pp. 90-94
    • Rajfer, J.1
  • 4
    • 0027958702 scopus 로고
    • Intracellular mechanism of penile erection in monkeys
    • Trigo-Rocha F et al. Intracellular mechanism of penile erection in monkeys. Neurourol Urodyn 1994; 13: 71-80.
    • (1994) Neurourol Urodyn , vol.13 , pp. 71-80
    • Trigo-Rocha, F.1
  • 5
    • 0032323162 scopus 로고    scopus 로고
    • Sildenafil, a type-5 cGMP phosphodiesterase inhibitor, specifically amplifies endogenous cGMP-dependent relaxation in rabbit corpus cavernosum smooth muscle in vitro
    • Chuang T, Strauss JD, Murphy RA, Steers WD. Sildenafil, a type-5 cGMP phosphodiesterase inhibitor, specifically amplifies endogenous cGMP-dependent relaxation in rabbit corpus cavernosum smooth muscle in vitro. J Urol 1998; 160: 257-261.
    • (1998) J Urol , vol.160 , pp. 257-261
    • Chuang, T.1    Strauss, J.D.2    Murphy, R.A.3    Steers, W.D.4
  • 6
    • 0028802726 scopus 로고
    • Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms
    • Beavo JA. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol Rev 1995; 75: 725-748.
    • (1995) Physiol Rev , vol.75 , pp. 725-748
    • Beavo, J.A.1
  • 7
    • 0032577224 scopus 로고    scopus 로고
    • Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase
    • Fisher DA et al. Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase. Biochem Biophys Res Commun 1998; 246: 570-577.
    • (1998) Biochem Biophys Res Commun , vol.246 , pp. 570-577
    • Fisher, D.A.1
  • 8
    • 0032546924 scopus 로고    scopus 로고
    • Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases
    • Soderling SH, Bayuga SJ, Beavo JA. Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J Biol Chem 1998; 273: 15553-15558.
    • (1998) J Biol Chem , vol.273 , pp. 15553-15558
    • Soderling, S.H.1    Bayuga, S.J.2    Beavo, J.A.3
  • 9
    • 0034724177 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A
    • Fawcett L et al. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. Proc Natl Acad Sci USA 2000; 97: 3702-3707.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 3702-3707
    • Fawcett, L.1
  • 10
    • 0034750923 scopus 로고    scopus 로고
    • Expression of different phosphodiesterase genes in human cavernous smooth muscle
    • Kuthe A et al. Expression of different phosphodiesterase genes in human cavernous smooth muscle. J Urol 2001; 165: 280-283.
    • (2001) J Urol , vol.165 , pp. 280-283
    • Kuthe, A.1
  • 11
    • 0033521110 scopus 로고    scopus 로고
    • Expression of an active, monomeric catalytic domain of the cGMP-binding cGMP-specific phosphodiesterase (PDE5)
    • Fink TL et al. Expression of an active, monomeric catalytic domain of the cGMP-binding cGMP-specific phosphodiesterase (PDE5). J Biol Chem 1999; 274: 34613-34620.
    • (1999) J Biol Chem , vol.274 , pp. 34613-34620
    • Fink, T.L.1
  • 12
    • 0025143899 scopus 로고
    • Substrate-and-kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP
    • Thomas MK, Francis SH, Corbin JD. Substrate-and-kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP. J Biol Chem 1990; 265: 124971-124978.
    • (1990) J Biol Chem , vol.265 , pp. 124971-124978
    • Thomas, M.K.1    Francis, S.H.2    Corbin, J.D.3
  • 13
    • 0036136639 scopus 로고    scopus 로고
    • Specific cGMP binding by the cGMP binding domains of cGMP-binding cGMP specific phosphodiesterase
    • Liu L et al. Specific cGMP binding by the cGMP binding domains of cGMP-binding cGMP specific phosphodiesterase. Cell Signal 2002; 14: 45-51.
    • (2002) Cell Signal , vol.14 , pp. 45-51
    • Liu, L.1
  • 14
    • 0034838812 scopus 로고    scopus 로고
    • Allosteric sites of phosphodiesterase-5 (PDE5). A potential role in negative feedback regulation of cGMP signaling in corpus cavernosum
    • Gopal VK, Francis SH, Corbin JD. Allosteric sites of phosphodiesterase-5 (PDE5). A potential role in negative feedback regulation of cGMP signaling in corpus cavernosum. Eur J Biochem 2001; 268: 3304-3312.
    • (2001) Eur J Biochem , vol.268 , pp. 3304-3312
    • Gopal, V.K.1    Francis, S.H.2    Corbin, J.D.3
  • 15
    • 0034108626 scopus 로고    scopus 로고
    • Phosphorylation of phosphodiesterase-5 by cyclic nucleotide-dependent protein kinase alters its catalytic and allosteric cGMP-binding activities
    • Corbin JD, Turko IV, Beasley A, Francis SH. Phosphorylation of phosphodiesterase-5 by cyclic nucleotide-dependent protein kinase alters its catalytic and allosteric cGMP-binding activities. Eur J Biochem 2000; 267: 2760-2767.
    • (2000) Eur J Biochem , vol.267 , pp. 2760-2767
    • Corbin, J.D.1    Turko, I.V.2    Beasley, A.3    Francis, S.H.4
  • 16
    • 0031938315 scopus 로고    scopus 로고
    • ANF elicits phosphorylation of the cGMP phosphodiesterase in vascular smooth muscle cells
    • Wyatt TA, Naftilan AJ, Francis SH, Corbin JD. ANF elicits phosphorylation of the cGMP phosphodiesterase in vascular smooth muscle cells. Am J Physiol 1998; 274: H448-H455.
    • (1998) Am J Physiol , vol.274
    • Wyatt, T.A.1    Naftilan, A.J.2    Francis, S.H.3    Corbin, J.D.4
  • 17
    • 0036479319 scopus 로고    scopus 로고
    • Regulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells
    • Rybalkin SD et al. Regulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells. J Biol Chem 2002; 277: 3310-3317.
    • (2002) J Biol Chem , vol.277 , pp. 3310-3317
    • Rybalkin, S.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.