Concomitant heterochromatinisation and down-regulation of gene expression unveils epigenetic silencing of RELB in an aggressive subset of chronic lymphocytic leukemia in males

BMC Medical Genomics

Volumn 3, Issue , 2010, Pages

  Marteau, Jean Brice ^a   Rigaud, Odile ^a   Brugat, Thibaut ^a,e,f   Gault, Nathalie ^a   Vallat, Laurent ^b   Kruhoffer, Mogens ^c   Orntoft, Torben F ^c   Nguyen Khac, Florence ^b   Chevillard, Sylvie ^d   Merle Beral, Hélène ^b   Delic, Jozo ^a,d  

^a DIF   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c AARHUS UNIVERSITY   (Denmark)

^d INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLCYTIDINE; ALPHA INTEGRIN; BISULFITE; CALCIUM CHANNEL; CD19 ANTIGEN; CONTACTIN ASSOCIATED PROTEIN LIKE 2; CYTIDINE DERIVATIVE; DEVELOPMENTALLY REGULATED GTP BINDING PROTEIN 2; DISC LARGE DROSOPHILA HOMOLOG ASSOCIATED PROTEIN 4; DNA POLYMERASE TRANSACTIVATED PROTEIN 6; G PROTEIN PATHWAY SUPPRESSOR 2; GENE PRODUCT; GENOMIC DNA; HETEROCHROMATIN PROTEIN 1; HETEROCHROMATIN PROTEIN 1ALPHA; HISTONE DEACETYLASE; HISTONE H3; HISTONE H3 LYSINE 9; HOM TES 103 TUMOR ANTIGEN LIKE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTEGRIN ALPHA E; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; PLECKSTRIN HOMOLOGY DOMAIN CONTAINING FAMILY B MEMBER 1; STAT3 PROTEIN; TRAFFICKING PROTEIN KINESIN BINDING 2; TRANSCRIPTION FACTOR PAX5; TRANSCRIPTION FACTOR RELB; TRICHOSTATIN A; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT CALCIUM CHANNEL P Q TYPE ALPHA 1A SUBUNIT; HISTONE; LYSINE; RELB PROTEIN, HUMAN;

ADULT; AGED; APOPTOSIS; ARTICLE; BINDING SITE; CHROMATIN IMMUNOPRECIPITATION; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA BINDING; DNA METHYLATION; DNA MICROARRAY; DOWN REGULATION; ENZYME INHIBITION; EPIGENETICS; FEMALE; GENDER; GENE EXPRESSION PROFILING; GENE REPRESSION; GENE SEQUENCE; GENE SILENCING; HETEROCHROMATIN; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IN SITU IMMUNOFLUORESCENT HETEROCHROMATIN LABELING; LEUKEMIA CELL; MALE; MICROSCOPY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METHYLATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RECORDING; TRANSCRIPTION INITIATION SITE; UPREGULATION; VIDEO MICROSCOPY RECORDING; CASE CONTROL STUDY; CHEMISTRY; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; SEXUAL DEVELOPMENT;

AGED; AGED, 80 AND OVER; APOPTOSIS; CASE-CONTROL STUDIES; DNA METHYLATION; DOWN-REGULATION; FEMALE; GENE EXPRESSION PROFILING; GENE SILENCING; HETEROCHROMATIN; HISTONES; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LYSINE; MALE; MIDDLE AGED; PROMOTER REGIONS, GENETIC; SEX CHARACTERISTICS; TRANSCRIPTION FACTOR RELB;

EID: 78049531155     PISSN: None     EISSN: 17558794     Source Type: Journal    
DOI: 10.1186/1755-8794-3-53     Document Type: Article

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