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Nishida and Kerr obtained a 1:1.5 and 1:1.7 ratio of Z: E isomers, respectively. Dixon however obtained a favorable 1.7:1 Z: E ratio by including an excess of either enantiomer of camphorsulfonic acid in the metathesis reaction mixture
-
Nishida and Kerr obtained a 1:1.5 and 1:1.7 ratio of Z: E isomers, respectively. Dixon however obtained a favorable 1.7:1 Z: E ratio by including an excess of either enantiomer of camphorsulfonic acid in the metathesis reaction mixture.
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19
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For a review of N -acyliminium ion cyclizations, see
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For reviews, see
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24
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A vinyl group was initially investigated, but its steric influence was found to be insufficient, as a 1:1 mixture of diastereomers was obtained from the cyclization to the corresponding tetracycle. These stereoisomers are presumably epimeric at C14
-
A vinyl group was initially investigated, but its steric influence was found to be insufficient, as a 1:1 mixture of diastereomers was obtained from the cyclization to the corresponding tetracycle. These stereoisomers are presumably epimeric at C14
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25
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78049497527
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Prepared in four steps from d -pyroglutamic acid in 67% overall yield. For details, see Supporting Information
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Prepared in four steps from d -pyroglutamic acid in 67% overall yield. For details, see Supporting Information.
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Another catalyst has been recently reported but was not investigated, see:; J. Am. Chem. Soc. 2010, 132, 11045
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