Hypothalamic paraventricular nucleus Gαq subunit protein pathways mediate vasopressin dysregulation and fluid retention in salt-sensitive rats

Endocrinology

Volumn 151, Issue 11, 2010, Pages 5403-5414

  Wainford, Richard D ^a,b   Kapusta, Daniel R ^a,b  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GTP BINDING PROTEIN ALPHA SUBUNIT GZ; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; NOCICEPTIN; OLIGODEOXYNUCLEOTIDE; SODIUM; UNCLASSIFIED DRUG; VASOPRESSIN; WATER; OPIATE PEPTIDE; VASOPRESSIN DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIURESIS; DOWN REGULATION; FLUID BALANCE; FLUID RETENTION; HIGH SODIUM INTAKE; HYPERTENSION; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SODIUM BALANCE; VASOPRESSIN BLOOD LEVEL; VASOPRESSIN RELEASE; ANALYSIS OF VARIANCE; ANIMAL; ANTERIOR HYPOTHALAMUS; BODY WATER; DAHL SALT SENSITIVE RAT; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; METABOLISM; PHYSIOLOGY; RANDOMIZATION; SALT INTAKE; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; BODY WATER; ENZYME-LINKED IMMUNOSORBENT ASSAY; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; MALE; OPIOID PEPTIDES; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RANDOM ALLOCATION; RATS; RATS, INBRED DAHL; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SODIUM CHLORIDE, DIETARY; VASOPRESSINS;

EID: 78049496229     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-0345     Document Type: Article

References (42)

1. Nielsen S, DiGiovanni SR, Christensen EI, Knepper MA, Harris HW 1993 Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney. Proc Natl Acad Sci USA 90: 11663-11667
2. Landgraf R, Malkinson T, Horn T, Veale WL, Lederis K, Pittman QJ 1990 Release of vasopressin and oxytocin by paraventricular stimulation in rats. Am J Physiol 258:R155-R159
3. Grindstaff RR, Cunningham JT 2001 Cardiovascular regulation of vasopressin neurons in the supraoptic nucleus. Exp Neurol 171: 219-226
4. Weiss ML, Hatton GI 1990 Collateral input to the paraventricular and supraoptic nuclei in rat. I. Afferents from the subfornical organ and the anteroventral third ventricle region. Brain Res Bull 24:231-238
5. Kashani A, Landaverde C, Medici V, Rossaro L 2008 Fluid retention in cirrhosis: pathophysiology and management. QJM 101:71-85 (Pubitemid 351234707)
6. Chatterjee K 2005 Neurohormonal activation in congestive heart failure and the role of vasopressin. Am J Cardiol 95:8B-13B
7. Serino R, Ueta Y, Hanamiya M, Nomura M, Yamamoto Y, Yamaguchi KI, Nakashima Y, Yamashita H 2001 Increased levels of hypothalamic neuronal nitric oxide synthase and vasopressin in salt-loaded Dahl rat. Auton Neurosci 87:225-235
8. Bayorh MA, Ogbolu EC, Williams E, Thierry-Palmer M, Sanford G, Emmett N, Harris-Hooker S, Socci RR, Chu TC, Chenault VM 1998 Possible mechanisms of salt-induced hypertension in Dahl salt-sensitive rats. Physiol Behav 65:563-568 (Pubitemid 29015774)
9. Wainford RD, Kurtz K, Kapusta DR 2008 Central G-alpha subunit protein-mediated control of cardiovascular function, urine output, and vasopressin secretion in conscious Sprague-Dawley rats. Am J Physiol 295:R535-R542
10. Haywood JR, Brennan TJ, Hinojosa C 1985 Neurohumoral mechanisms of sodium-dependent hypertension. Fed Proc 44:2393-2399
11. Gunnet JW, Wines P, Xiang M, Rybczynski P, Andrade-Gordon P, de Garavilla L, Parry TJ, Cheung WM, Minor L, Demarest KT, Maryanoff BE, Damiano BP 2008 Pharmacological characterization of RWJ-676070, a dual vasopressin V(1A)/V(2) receptor antagonist. Eur J Pharmacol 590:333-342
12. Wainford RD, Kapusta DR 2009 Chronic high-NaCl intake prolongs the cardiorenal responses to central N/OFQ and produces regional changes in the endogenous brain NOP receptor system. Am J Physiol 296:R280-R288
13. Lighthall GK, Hamilton BP, Hamlyn JM 2004 Identification of salt-sensitive genes in the kidneys of Dahl rats. J Hypertens 22:1487-1494 (Pubitemid 39037598)
14. Standifer KM, Rossi GC, Pasternak GW 1996 Differential blockade of opioid analgesia by antisense oligodeoxynucleotides directed against various G protein alpha subunits. Mol Pharmacol 50:293-298
15. Hadjimarkou MM, Silva RM, Rossi GC, Pasternak GW, Bodnar RJ 2002 Feeding induced by food deprivation is differentially reduced by G-protein alpha-subunit antisense probes in rats. Brain Res 955: 45-54
16. 2 and orphanin FQ/nociceptin (OFQ/N) produce similar cardiovascular and renal responses in conscious rats. J Pharmacol Exp Ther 289:173-180
17. Kapusta DR, Kenigs VA 1999 Cardiovascular and renal responses produced by central orphanin FQ/nociceptin occur independent of renal nerves. Am J Physiol 277:R987-R995
18. Paxinos G, Watson C 1998 The Rat Brain in Stereotaxic Coordinates, 4th Ed, Academic Press, New York
19. Kapusta DR, Sezen SF, Chang JK, Lippton H, Kenigs VA 1997 Diuretic and antinatriuretic responses produced by the endogenous opioid-like peptide, nociceptin (orphanin FQ). Life Sci 60:PL15-PL21.
20. Hadrup N, Petersen JS, Windfeld S, Risom L, Andersen CB, Nielsen S, Christensen S, Jonassen TE 2007 Differential down-regulation of aquaporin-2 in rat kidney zones by peripheral nociceptin/orphanin FQ receptor agonism and vasopressin type-2 receptor antagonism. J Pharmacol Exp Ther 323:516-524
21. Kakiya S, Murase T, Arima H, Yokoi H, Iwasaki Y, Miura Y, Oiso Y 2000 Role of endogenous nociceptin in the regulation of arginine vasopressin release in conscious rats. Endocrinology 141:4466-4471 (Pubitemid 32055122)
22. Matsuguchi H, Schmid PG, Van Orden D, Mark AL 1981 Does vasopressin contribute to salt-induced hypertension in the Dahl strain? Hypertension 3:174-181
23. Krowicki ZK, Kapusta DR 2006 Tonic nociceptinergic inputs to neurons in the hypothalamic paraventricular nucleus contribute to sympathetic vasomotor tone and water and electrolyte homeostasis in conscious rats. J Pharmacol Exp Ther 317:446-453
24. Kondo K, Murase T, Otake K, Ito M, Kurimoto F, Oiso Y 1993 Galanin as a physiological neurotransmitter in hemodynamic control of arginine vasopressin release in rats. Neuroendocrinology 57: 224-229 (Pubitemid 23147802)
25. Ruginsk SG, Oliveira FR, Margatho LO, Vivas L, Elias LL, Antunes- Rodrigues J 2007 Glucocorticoid modulation of neuronal activity and hormone secretion induced by blood volume expansion. Exp Neurol 206:192-200 (Pubitemid 47094763)
26. Gross V, Tank J, Obst M, Plehm R, Blumer KJ, Diedrich A, Jordan J, Luft FC 2005 Autonomic nervous system and blood pressure regulation in RGS2-deficient mice. Am J Physiol 288:R1134-R1142
27. Yang J, Kamide K, Kokubo Y, Takiuchi S, Tanaka C, Banno M, Miwa Y, Yoshii M, Horio T, Okayama A, Tomoike H, Kawano Y, Miyata T 2005 Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population. J Hypertens 23:1497-1505
28. Gu S, Tirgari S, Heximer SP 2008 The RGS2 gene product from a candidate hypertension allele shows decreased plasma membrane association and inhibition of Gq. Mol Pharmacol 73:1037-1043
29. Guyton AC, Coleman TG, Cowley Jr AV, Scheel KW, Manning Jr RD, Norman Jr RA 1972 Arterial pressure regulation. Overriding dominance of the kidneys in long-term regulation and in hypertension. Am J Med 52:584-594.
30. Simchon S, Manger WM, Carlin RD, Peeters LL, Rodriguez J, Batista D, Brown T, Merchant NB, Jan KM, Chien S 1989 Salt-induced hypertension in Dahl salt-sensitive rats. Hemodynamics and renal responses. Hypertension 13:612-621
31. Greene AS, Yu ZY, Roman RJ, Cowley Jr AW 1990 Role of blood volume expansion in Dahl rat model of hypertension. Am J Physiol 258:H508-H514.
32. Manger WM, Simchon S, Stokes MB, Reidy JJ, Kumar AR, Baer L, Gallo G, Haddy FJ 2009 Renal functional, not morphological, abnormalities account for salt sensitivity in Dahl rats. J Hypertens 27:587-598
33. McLoone VI, Ringwood JV, Van Vliet BN 2009 A multi-component model of the dynamics of salt-induced hypertension in Dahl-S rats. BMC Physiol 9:20
34. Dampney RAL, Horiuchi J, Killinger S, Sheriff MJ, Tan PSP, Mc-Dowall LM 2005 Long-term regulation of arterial blood pressure by hypothalamic nuclei: some critical questions. Clin Exp Pharmacol Physiol 32:419-425
35. Gabor A, Leenen FHH 2009 Mechanisms in the PVN mediating local and central sodium-induced hypertension in Wistar rats. Am J Physiol 296:R618-R630
36. Shi P, Stocker SD, Toney GM 2007 Organum vasculosum laminae terminalis contributes to increased sympathetic nerve activity induced by central hyperosmolality. Am J Phys 293:R2279-R2289
37. Roman RJ, Hoagland KM, Lopez B, Kwitek AE, Garrett MR, Rapp JP, Lazar J, Jacob HJ, Sarkis A 2006 Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats. Am J Physiol 290:F1463-F1471
38. Hiwatari M, Abe K, Imai Y, Yoshinaga K, Johnston CI 1986 Evidence for the implication of endogenous vasopressin in cardiovascular response to central alpha-adrenoceptor stimulation. Jpn Circ J 50:1149-1154
39. Stone JD, Crofton JT, Share L 1989 Sex differences in central adrenergic control of vasopressin release. Am J Physiol 257:R1040-R1045
40. Sato K, Crofton JT, Wang YX, Share L 1995 Effects of gender on the central actions of neuropeptide Y and norepinephrine on vasopressin and blood pressure in the rat. Brain Res 689:71-78
41. Unger T, Bles F, Ganten D, Lang RE, Rettig R, Schwab NA 1983 Gabaergic stimulation inhibits central actions of angiotensin II: pressor responses, drinking and release of vasopressin. Eur J Pharmacol 90:1-9
42. Huang BS, Leenen FH 1998 Both brain angiotensin II and "ouabain" contribute to sympathoexcitation and hypertension in Dahl S rats on high salt intake. Hypertension 32:1028-1033