Central G-alpha subunit protein-mediated control of cardiovascular function, urine output, and vasopressin secretion in conscious Sprague-Dawley rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 295, Issue 2, 2008, Pages

  Wainford, Richard D ^a   Kurtz, Kristine ^a   Kapusta, Daniel R ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiovascular and renal excretory function; Central G subunit proteins; Central nervous system; Nociceptin orphanin FQ; Vasopressin antidiuretic hormone

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; NOCICEPTIN; OLIGODEOXYNUCLEOTIDE; VASOPRESSIN; (NPHE(1),ARG(14),LYS(15))N OFQ NH(2); (NPHE(1),ARG(14),LYS(15))N-OFQ NH(2); ARGIPRESSIN; GNAZ PROTEIN, RAT; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; NOCICEPTIN RECEPTOR; OLIGODEOXYRIBONUCLEOTIDE; OPIATE PEPTIDE; OPIATE RECEPTOR; PERTUSSIS TOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; DIURESIS; DOWN REGULATION; HEART RATE; HYPOTENSION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; URINARY EXCRETION; URINE VOLUME; VASOPRESSIN RELEASE; ANIMAL; BLOOD; BLOOD PRESSURE; BRAIN; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; METABOLISM; MICTURITION; SECRETION; SPRAGUE DAWLEY RAT; TIME; WATER DEPRIVATION;

ANIMALS; ARGININE VASOPRESSIN; BLOOD PRESSURE; BRAIN; CARDIOVASCULAR PHYSIOLOGY; DIURESIS; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HEART RATE; INJECTIONS, INTRAVENTRICULAR; MALE; OLIGODEOXYRIBONUCLEOTIDES; OPIOID PEPTIDES; PERTUSSIS TOXIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID; TIME FACTORS; URINATION; WATER DEPRIVATION;

EID: 51149105054     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00043.2008     Document Type: Article

References (26)

1. Calo G, Guerrini R, Rizzi A, Salvadori S, Burmeister M, Kapusta DR, Lambert DG, Regoli D. UFP-101, a peptide antagonist selective for the nociceptin/orphanin FQ receptor. CNS Drug Rev 11: 97-112, 2005.
2. Chan JSC, Yung LY, Lee JWM, Wi YL, Pei G, Wong YH. Pertussis toxin-insensitive signaling of the ORL1 receptor: coupling to Gz and G16 proteins. J Neurochem 71: 2203-2210, 1998.
3. 2+ channels in pertussis toxin induced antagonism of U50, 488H analgesia and hypothermia. Brain Res 946: 191-191, 2002.
4. Hadjimarkou MM, Silva RM, Rossi GC, Pasternak GW, Bodnar RJ. Feeding induced by food depravation is differentially reduced by G-protein α-subunit antisense probes in rats. Brain Res 955: 45-54, 2002.
5. Hawes BE, Fried S, Yao X, Weig B, Graziano MP. Nociceptin (ORL-1) and μ-opioid receptors mediate mitogen-activated protein kinase activation in CHO cells through a Gi-coupled signaling pathway: Evidence for distinct mechanisms of agonist-mediated desensitization. J Neurochem 71: 1024-1033, 1998.
6. Isgor C, Shieh KR, Akil H, Watson J. Colocalization of estrogen beta-receptor messenger RNA with orphanin FQ, vasopressin and oxytocin in the rat hypothalamic paraventricular and supraoptic nuclei. Anat Embryol 206:461-469, 2003.
7. Jeong SW, Ikeda SRG. Protein α subunit Gαz couples neurotransmitter receptors to ion channels in sympathetic neurons. Neuron 21: 1201-1212, 1998.
8. Joshi S, Lee JWM, Wong YH. Stimulation of phospholipase C by the cloned μ, δ, and κ opioid receptors via chimeric Gαq mutants. Eur J Neurosci 11: 383-388, 1999.
9. Kakiya S, Murase T, Aimra H, Yokoi H, Iwasaki Y, Miura Y, Oiso Y. Role of endogenous nociceptin in the regulation of arginine vasopressin release in conscious rats. Endocrinology 141: 4466-4471, 2000.
10. Kapusta DR, Sezen SF, Chang JK, Lippton H, Kenigs VA. Diuretic and antinaturetic responses produced by the endogenous opioid-like peptide, nociceptin (orphanin FQ). Life Sci 60: PL15-PL21, 1997.
11. 2 and orphanin FQ/nociceptin (OFQ/N) produce similar cardiovascular and renal responses in conscious rats. J Pharmacol Exp Therap 289: 173-180, 1999.
12. Kapusta DR, Kenigs VA. Cardiovascular and renal responses produced by central orphanin FQ/nociceptin occur independent of renal nerves. Am J Physiol 77: R987-R995, 1999.
13. Katada T, Oinuma M, Ui M. Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein. Proc Natl Acad Sci USA 79: 3129-3133, 1982.
14. Krowicki ZK, Kapusta DR. Tonic nociceptinergic inputs to neurons in the hypothalamic paraventricular nucleus contribute to sympathetic vasomotor tone and water and electrolyte homeostasis in conscious rats. J Pharmacol Exp Ther 317: 446-453, 2006.
15. 1 receptor. Nature 377: 532-535, 1995.
16. 1) receptor. Nature 377: 532-535, 2000.
17. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates, 4th ed. New York: Academic, 1998.
18. Reinscheid RK, Nothacker HP, Bourson A, Ardati A, Henningsen RA, Bunzow JR, Grandy DK, Langen H, Monsma FJ Jr, Civelli O. Orphanin FQ: a neuropeptide that activates an opioid G protein-coupled receptor. Science 270: 792-794, 1995.
19. Rossi GC, Standifer KM, Pasternak GW. Differential blockade of morphine, and morphine-6 beta-glucuronide analgesia by antisense oligodeoxynucleotides directed against M.OR-1 and G-protein alpha subunits in rats. Neurosci Lett 198: 99-102, 1995.
20. Sapru HN, Chitravanshi VC. Responses to microinjections of endomorphin and nociceptin into the medullary cardiovascular areas. Clin Exp Pharmacol Physiol 29: 243-247, 2002.
21. Shirasaka T, Miyahara S, Takasaki M, Kannan H. Nociceptin/orphanin FQ and [Phe(1)psi(CH2-NH)Gly2]nociceptin(1-13)NH2 modulates the activity of hypothalamic paraventricular nucleus neurons in vitro. Brain Res 890: 147-153, 2002.
22. Silva RM, Rossi GC, Mathis JP, Standifer KM, Pasternak GW, Bodnar RJ. Morphine and morphinw-6-beta-glucaronide-induced feeding are differentially reduced by G-protein alpha-subunit antisense in rats. Brain Res 876: 62-75, 2000.
23. + conductance by orphanin-FQ/nociceptin in vasopressin-containing neurons. Neuroendocrinology 385-396, 1999.
24. Standifer KM, Rossi GC, Pasternak GW. Differential blockade of opioid analgesia by antisense oligodeoxynucleotides directed against various G protein alpha subunits. Mol Pharmacol 50: 293-298, 1996.
25. Tso W, Wong YH. Opioid receptor-like (ORL1) receptor utilizes both GoA and GoB for signal transduction. Prot Pep Lett 13: 437- 441, 2006.
26. Yung LY, Joshi SA, Chan RY, Chan JS, Pei G, Wong YH. G alphaL1 (Galpha14) couples the opioid receptor-like 1 receptor to stimulation of phospholipase C. J Pharma Exp Ther 288: 232-238, 1999.