메뉴 건너뛰기




Volumn 7, Issue 11, 2010, Pages 3765-3774

Treatment of 161 men with symptomatic late onset hypogonadism with long-acting parenteral testosterone undecanoate: Effects on body composition, lipids, and psychosexual complaints

Author keywords

International Index of Erectile Function; Late Onset Hypogonadism; Prostate Safety; Sex Hormone Binding Globulin; Testosterone Deficiency Syndrome; Testosterone Undecanoate; Thai; Waist Circumference

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LONG ACTING DRUG; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROSTATE SPECIFIC ANTIGEN; TESTOSTERONE; TESTOSTERONE UNDECANOATE; TRIACYLGLYCEROL;

EID: 78049484182     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2010.01994.x     Document Type: Article
Times cited : (43)

References (46)
  • 1
    • 34548722899 scopus 로고    scopus 로고
    • Age-related changes in serum testosterone and sex hormone binding globulin in Australian men: Longitudinal analyses of two geographically separate regional cohorts
    • Liu PY, Beilin J, Meier C, Nguyen TV, Center JR, Leedman PJ, Seibel MJ, Eisman JA, Handelsman DJ. Age-related changes in serum testosterone and sex hormone binding globulin in Australian men: Longitudinal analyses of two geographically separate regional cohorts. J Clin Endocrinol Metab 2007;92:3599-603.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 3599-3603
    • Liu, P.Y.1    Beilin, J.2    Meier, C.3    Nguyen, T.V.4    Center, J.R.5    Leedman, P.J.6    Seibel, M.J.7    Eisman, J.A.8    Handelsman, D.J.9
  • 4
    • 33748120349 scopus 로고    scopus 로고
    • The age related decrease in testosterone is significantly exacerbated in obese men with the metabolic syndrome. What are the implications for the relatively high incidence of erectile dysfunction observed in these men?
    • discussion 27-8.
    • Kaplan SA, Meehan AG, Shah A. The age related decrease in testosterone is significantly exacerbated in obese men with the metabolic syndrome. What are the implications for the relatively high incidence of erectile dysfunction observed in these men? J Urol 2006;176:1524-7. discussion 27-8.
    • (2006) J Urol , vol.176 , pp. 1524-1527
    • Kaplan, S.A.1    Meehan, A.G.2    Shah, A.3
  • 5
    • 64049106282 scopus 로고    scopus 로고
    • Metabolic complications of androgen deprivation therapy for prostate cancer
    • discussion 07-8.
    • Saylor PJ, Smith MR. Metabolic complications of androgen deprivation therapy for prostate cancer. J Urol 2009;181:1998-2006. discussion 07-8.
    • (2009) J Urol , vol.181 , pp. 1998-2006
    • Saylor, P.J.1    Smith, M.R.2
  • 6
    • 35948930594 scopus 로고    scopus 로고
    • Acute sex steroid withdrawal reduces insulin sensitivity in healthy men with idiopathic hypogonadotropic hypogonadism
    • Yialamas MA, Dwyer AA, Hanley E, Lee H, Pitteloud N, Hayes FJ. Acute sex steroid withdrawal reduces insulin sensitivity in healthy men with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2007;92:4254-9.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4254-4259
    • Yialamas, M.A.1    Dwyer, A.A.2    Hanley, E.3    Lee, H.4    Pitteloud, N.5    Hayes, F.J.6
  • 7
    • 38149032364 scopus 로고    scopus 로고
    • Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men
    • Allan CA, Strauss BJ, Burger HG, Forbes EA, McLachlan RI. Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men. J Clin Endocrinol Metab 2008;93:139-46.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 139-146
    • Allan, C.A.1    Strauss, B.J.2    Burger, H.G.3    Forbes, E.A.4    McLachlan, R.I.5
  • 8
    • 38049169172 scopus 로고    scopus 로고
    • A dose-response study of testosterone on sexual dysfunction and features of the metabolic syndrome using testosterone gel and parenteral testosterone undecanoate
    • Saad F, Gooren LJ, Haider A, Yassin A. A dose-response study of testosterone on sexual dysfunction and features of the metabolic syndrome using testosterone gel and parenteral testosterone undecanoate. J Androl 2008;29:102-5.
    • (2008) J Androl , vol.29 , pp. 102-105
    • Saad, F.1    Gooren, L.J.2    Haider, A.3    Yassin, A.4
  • 9
    • 69949178483 scopus 로고    scopus 로고
    • 52-week treatment with diet and exercise plus transdermal testosterone reverses the metabolic syndrome and improves glycaemic control in men with newly diagnosed type 2 diabetes and subnormal plasma testosterone
    • Heufelder AE, Saad F, Bunck MC, Gooren LJ. 52-week treatment with diet and exercise plus transdermal testosterone reverses the metabolic syndrome and improves glycaemic control in men with newly diagnosed type 2 diabetes and subnormal plasma testosterone. J Androl 2009;30:726-33.
    • (2009) J Androl , vol.30 , pp. 726-733
    • Heufelder, A.E.1    Saad, F.2    Bunck, M.C.3    Gooren, L.J.4
  • 13
    • 33751533215 scopus 로고    scopus 로고
    • Association of specific symptoms and metabolic risks with serum testosterone in older men
    • Zitzmann M, Faber S, Nieschlag E. Association of specific symptoms and metabolic risks with serum testosterone in older men. J Clin Endocrinol Metab 2006;91:4335-43.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4335-4343
    • Zitzmann, M.1    Faber, S.2    Nieschlag, E.3
  • 14
    • 70350245011 scopus 로고    scopus 로고
    • Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
    • Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr. Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009;120:1640-5.
    • (2009) Circulation , vol.120 , pp. 1640-1645
    • Alberti, K.G.1    Eckel, R.H.2    Grundy, S.M.3    Zimmet, P.Z.4    Cleeman, J.I.5    Donato, K.A.6    Fruchart, J.C.7    James, W.P.8    Loria, C.M.9    Smith, S.C.10
  • 15
    • 70049096996 scopus 로고    scopus 로고
    • Following the common association between testosterone deficiency and diabetes mellitus, can testosterone be regarded as a new therapy for diabetes?
    • Corona G, Mannucci E, Forti G, Maggi M. Following the common association between testosterone deficiency and diabetes mellitus, can testosterone be regarded as a new therapy for diabetes? Int J Androl 2009;32:431-41.
    • (2009) Int J Androl , vol.32 , pp. 431-441
    • Corona, G.1    Mannucci, E.2    Forti, G.3    Maggi, M.4
  • 18
    • 0035200778 scopus 로고    scopus 로고
    • Report from a Centers for Disease Control and Prevention Workshop on use of adult anthropometry for public health and primary health care
    • Seidell JC, Kahn HS, Williamson DF, Lissner L, Valdez R. Report from a Centers for Disease Control and Prevention Workshop on use of adult anthropometry for public health and primary health care. Am J Clin Nutr 2001;73:123-6.
    • (2001) Am J Clin Nutr , vol.73 , pp. 123-126
    • Seidell, J.C.1    Kahn, H.S.2    Williamson, D.F.3    Lissner, L.4    Valdez, R.5
  • 20
    • 33746859070 scopus 로고    scopus 로고
    • Aging Males' Symptoms scale: A standardized instrument for the practice
    • Heinemann LA. Aging Males' Symptoms scale: A standardized instrument for the practice. J Endocrinol Invest 2005;28:34-8.
    • (2005) J Endocrinol Invest , vol.28 , pp. 34-38
    • Heinemann, L.A.1
  • 21
    • 0030926566 scopus 로고    scopus 로고
    • The International Index of Erectile Function (IIEF): A multidimensional scale for assessment of erectile dysfunction
    • Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The International Index of Erectile Function (IIEF): A multidimensional scale for assessment of erectile dysfunction. Urology 1997;49:822-30.
    • (1997) Urology , vol.49 , pp. 822-830
    • Rosen, R.C.1    Riley, A.2    Wagner, G.3    Osterloh, I.H.4    Kirkpatrick, J.5    Mishra, A.6
  • 22
    • 4243119542 scopus 로고    scopus 로고
    • Validation of a general measure of treatment satisfaction, the Treatment Satisfaction Questionnaire for Medication (TSQM), using a national panel study of chronic disease
    • Atkinson MJ, Sinha A, Hass SL, Colman SS, Kumar RN, Brod M, Rowland CR. Validation of a general measure of treatment satisfaction, the Treatment Satisfaction Questionnaire for Medication (TSQM), using a national panel study of chronic disease. Health Qual Life Outcomes 2004;2:12.
    • (2004) Health Qual Life Outcomes , vol.2 , pp. 12
    • Atkinson, M.J.1    Sinha, A.2    Hass, S.L.3    Colman, S.S.4    Kumar, R.N.5    Brod, M.6    Rowland, C.R.7
  • 23
    • 65649111800 scopus 로고    scopus 로고
    • Validation of an abbreviated Treatment Satisfaction Questionnaire for Medication (TSQM-9) among patients on antihypertensive medications
    • Bharmal M, Payne K, Atkinson MJ, Desrosiers MP, Morisky DE, Gemmen E. Validation of an abbreviated Treatment Satisfaction Questionnaire for Medication (TSQM-9) among patients on antihypertensive medications. Health Qual Life Outcomes 2009;7:36.
    • (2009) Health Qual Life Outcomes , vol.7 , pp. 36
    • Bharmal, M.1    Payne, K.2    Atkinson, M.J.3    Desrosiers, M.P.4    Morisky, D.E.5    Gemmen, E.6
  • 24
    • 34447537804 scopus 로고    scopus 로고
    • The burden of testosterone deficiency syndrome in adult men: Economic and quality-of-life impact
    • Maggi M, Schulman C, Quinton R, Langham S, Uhl-Hochgraeber K. The burden of testosterone deficiency syndrome in adult men: Economic and quality-of-life impact. J Sex Med 2007;4:1056-69.
    • (2007) J Sex Med , vol.4 , pp. 1056-1069
    • Maggi, M.1    Schulman, C.2    Quinton, R.3    Langham, S.4    Uhl-Hochgraeber, K.5
  • 25
    • 57449105878 scopus 로고    scopus 로고
    • Health-related quality of life instruments in studies of adult men with testosterone deficiency syndrome: A critical assessment
    • Langham S, Maggi M, Schulman C, Quinton R, Uhl-Hochgraeber K. Health-related quality of life instruments in studies of adult men with testosterone deficiency syndrome: A critical assessment. J Sex Med 2008;5:2842-52.
    • (2008) J Sex Med , vol.5 , pp. 2842-2852
    • Langham, S.1    Maggi, M.2    Schulman, C.3    Quinton, R.4    Uhl-Hochgraeber, K.5
  • 27
    • 15944404290 scopus 로고    scopus 로고
    • Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T
    • Page ST, Amory JK, Bowman FD, Anawalt BD, Matsumoto AM, Bremner WJ, Tenover JL. Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. J Clin Endocrinol Metab 2005;90:1502-10.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1502-1510
    • Page, S.T.1    Amory, J.K.2    Bowman, F.D.3    Anawalt, B.D.4    Matsumoto, A.M.5    Bremner, W.J.6    Tenover, J.L.7
  • 28
    • 0012619789 scopus 로고    scopus 로고
    • AA2500 testosterone gel normalizes androgen levels in aging males with improvements in body composition and sexual function
    • Steidle C, Schwartz S, Jacoby K, Sebree T, Smith T, Bachand R. AA2500 testosterone gel normalizes androgen levels in aging males with improvements in body composition and sexual function. J Clin Endocrinol Metab 2003;88:2673-81.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2673-2681
    • Steidle, C.1    Schwartz, S.2    Jacoby, K.3    Sebree, T.4    Smith, T.5    Bachand, R.6
  • 29
    • 77949503625 scopus 로고    scopus 로고
    • Improvement of the metabolic syndrome and of non-alcoholic liver steatosis upon treatment of hypogonadal elderly men with parenteral testosterone undecanoate
    • Haider A, Gooren LJ, Padungtod P, Saad F. Improvement of the metabolic syndrome and of non-alcoholic liver steatosis upon treatment of hypogonadal elderly men with parenteral testosterone undecanoate. Exp Clin Endocrinol Diabetes 2010;118:167-71.
    • (2010) Exp Clin Endocrinol Diabetes , vol.118 , pp. 167-171
    • Haider, A.1    Gooren, L.J.2    Padungtod, P.3    Saad, F.4
  • 30
  • 32
    • 52949086447 scopus 로고    scopus 로고
    • The effect of testosterone therapy on lower urinary tract symptoms/bladder and sexual functions in men with symptomatic late-onset hypogonadism
    • Karazindiyanoglu S, Cayan S. The effect of testosterone therapy on lower urinary tract symptoms/bladder and sexual functions in men with symptomatic late-onset hypogonadism. Aging Male 2008;11:146-9.
    • (2008) Aging Male , vol.11 , pp. 146-149
    • Karazindiyanoglu, S.1    Cayan, S.2
  • 33
    • 60149096172 scopus 로고    scopus 로고
    • Risk of late-onset hypogonadism (andropause) in Brazilian men over 50 years of age with osteoporosis: Usefulness of screening questionnaires
    • Clapauch R, Braga DJ, Marinheiro LP, Buksman S, Schrank Y. Risk of late-onset hypogonadism (andropause) in Brazilian men over 50 years of age with osteoporosis: Usefulness of screening questionnaires. Arq Bras Endocrinol Metabol 2008;52:1439-47.
    • (2008) Arq Bras Endocrinol Metabol , vol.52 , pp. 1439-1447
    • Clapauch, R.1    Braga, D.J.2    Marinheiro, L.P.3    Buksman, S.4    Schrank, Y.5
  • 34
    • 13844320651 scopus 로고    scopus 로고
    • Low testosterone levels predict incident depressive illness in older men: Effects of age and medical morbidity
    • Shores MM, Moceri VM, Sloan KL, Matsumoto AM, Kivlahan DR. Low testosterone levels predict incident depressive illness in older men: Effects of age and medical morbidity. J Clin Psychiatry 2005;66:7-14.
    • (2005) J Clin Psychiatry , vol.66 , pp. 7-14
    • Shores, M.M.1    Moceri, V.M.2    Sloan, K.L.3    Matsumoto, A.M.4    Kivlahan, D.R.5
  • 35
    • 68049144803 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of testosterone treatment in hypogonadal older men with subthreshold depression (dysthymia or minor depression)
    • Shores MM, Kivlahan DR, Sadak TI, Li EJ, Matsumoto AM. A randomized, double-blind, placebo-controlled study of testosterone treatment in hypogonadal older men with subthreshold depression (dysthymia or minor depression). J Clin Psychiatry 2009;70:1009-16.
    • (2009) J Clin Psychiatry , vol.70 , pp. 1009-1016
    • Shores, M.M.1    Kivlahan, D.R.2    Sadak, T.I.3    Li, E.J.4    Matsumoto, A.M.5
  • 36
    • 67649274349 scopus 로고    scopus 로고
    • Effects of testosterone replacement in middle-aged men with dysthymia: A randomized, placebo-controlled clinical trial
    • Seidman SN, Orr G, Raviv G, Levi R, Roose SP, Kravitz E, Amiaz R, Weiser M. Effects of testosterone replacement in middle-aged men with dysthymia: A randomized, placebo-controlled clinical trial. J Clin Psychopharmacol 2009;29:216-21.
    • (2009) J Clin Psychopharmacol , vol.29 , pp. 216-221
    • Seidman, S.N.1    Orr, G.2    Raviv, G.3    Levi, R.4    Roose, S.P.5    Kravitz, E.6    Amiaz, R.7    Weiser, M.8
  • 39
    • 29144469309 scopus 로고    scopus 로고
    • Adverse events associated with testosterone replacement in middle-aged and older men: A meta-analysis of randomized, placebo-controlled trials
    • Calof OM, Singh AB, Lee ML, Kenny AM, Urban RJ, Tenover JL, Bhasin S. Adverse events associated with testosterone replacement in middle-aged and older men: A meta-analysis of randomized, placebo-controlled trials. J Gerontol A Biol Sci Med Sci 2005;60:1451-7.
    • (2005) J Gerontol A Biol Sci Med Sci , vol.60 , pp. 1451-1457
    • Calof, O.M.1    Singh, A.B.2    Lee, M.L.3    Kenny, A.M.4    Urban, R.J.5    Tenover, J.L.6    Bhasin, S.7
  • 40
    • 70449585552 scopus 로고    scopus 로고
    • Impact of long-term testosterone treatment on plasma levels of free TFPI and TF-induced thrombin generation ex vivo in elderly men with low testosterone levels
    • Agledahl I, Brodin E, Svartberg J, Hansen JB. Impact of long-term testosterone treatment on plasma levels of free TFPI and TF-induced thrombin generation ex vivo in elderly men with low testosterone levels. Thromb Haemost 2009;102:945-50.
    • (2009) Thromb Haemost , vol.102 , pp. 945-950
    • Agledahl, I.1    Brodin, E.2    Svartberg, J.3    Hansen, J.B.4
  • 41
    • 77957834802 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of long-acting testosterone undecanoate injections in hypogonadal men: An 84-week phase III clinical trial
    • Epub ahead of print.
    • Wang C, Harnett M, Dobs A, Swerdloff RS. Pharmacokinetics and safety of long-acting testosterone undecanoate injections in hypogonadal men: An 84-week phase III clinical trial. J Androl 2010;[Epub ahead of print.
    • (2010) J Androl
    • Wang, C.1    Harnett, M.2    Dobs, A.3    Swerdloff, R.S.4
  • 42
    • 78049484486 scopus 로고    scopus 로고
    • 343 Safety and efficacy of intramuscular injections of 1000 mg testosterone undecanoate: A prospective multicenter study in hypogonadal men under conditions resembling real-life situations
    • Behre HM, Elliesen J. 343 Safety and efficacy of intramuscular injections of 1000 mg testosterone undecanoate: A prospective multicenter study in hypogonadal men under conditions resembling real-life situations. Eur Urol Suppl 2007;6:108.
    • (2007) Eur Urol Suppl , vol.6 , pp. 108
    • Behre, H.M.1    Elliesen, J.2
  • 45
    • 59349117364 scopus 로고    scopus 로고
    • The effects of treating male hypogonadism on couples' sexual desire and function
    • Conaglen JV, Conaglen HM. The effects of treating male hypogonadism on couples' sexual desire and function. J Sex Med 2009;6:456-63.
    • (2009) J Sex Med , vol.6 , pp. 456-463
    • Conaglen, J.V.1    Conaglen, H.M.2
  • 46
    • 77749280549 scopus 로고    scopus 로고
    • Factors influencing time course of pain after depot oil intramuscular injection of testosterone undecanoate
    • Sartorius G, Fennell C, Spasevska S, Turner L, Conway AJ, Handelsman DJ. Factors influencing time course of pain after depot oil intramuscular injection of testosterone undecanoate. Asian J Androl 2010;12:227-33.
    • (2010) Asian J Androl , vol.12 , pp. 227-233
    • Sartorius, G.1    Fennell, C.2    Spasevska, S.3    Turner, L.4    Conway, A.J.5    Handelsman, D.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.