A size threshold limits prion transmission and establishes phenotypic diversity

Science

Volumn 330, Issue 6004, 2010, Pages 680-683

  Derdowski, Aaron ^a   Sindi, Suzanne S ^a,b   Klaips, Courtney L ^a   DiSalvo, Susanne ^a   Serio, Tricia R ^a  

^a BROWN UNIVERSITY   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; CHAPERONE; PRION PROTEIN;

CELL ORGANELLE; FRAGMENTATION; HETEROGENEITY; HYPOTHESIS TESTING; MOLECULAR ANALYSIS; NUMERICAL MODEL; PHENOTYPE; POPULATION STRUCTURE; PROTEIN; THRESHOLD;

ARTICLE; NONHUMAN; PHENOTYPIC VARIATION; PRION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN FOLDING; YEAST;

ALGORITHMS; CELL DIVISION; COMPUTER SIMULATION; PEPTIDE TERMINATION FACTORS; PHENOTYPE; PRIONS; PROTEIN CONFORMATION; PROTEIN FOLDING; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 78049408567     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1197785     Document Type: Article

References (32)

1. J. Collinge, A. R. Clarke, Science 318, 930 (2007).
2. L. Benkemoun, S. J. Saupe, Fungal Genet. Biol. 43, 789 (2006).
3. S. B. Prusiner, Science 216, 136 (1982).
4. J. A. Pezza, T. R. Serio, Prion 1, 36 (2007).
5. M. Tanaka, S. R. Collins, B. H. Toyama, J. S. Weissman, Nature 442, 585 (2006).
6. B. Cox, F. Ness, M. Tuite, Genetics 165, 23 (2003).
7. S. S. Sindi, T. R. Serio, Curr. Opin. Microbiol. 12, 623 (2009).
8. I. L. Derkatch, Y. O. Chernoff, V. V. Kushnirov, S. G. Inge-Vechtomov, S. W. Liebman, Genetics 144, 1375 (1996).
9. S. M. Uptain, G. J. Sawicki, B. Caughey, S. Lindquist, EMBO J. 20, 6236 (2001).
10. P. Zhou et al., EMBO J. 18, 1182 (1999).
11. D. S. Kryndushkin, I. M. Alexandrov, M. D. Ter-Avanesyan, V. V. Kushnirov, J. Biol. Chem. 278, 49636 (2003).
12. S. N. Bagriantsev, V. V. Kushnirov, S. W. Liebman, Methods Enzymol. 412, 33 (2006).
13. Materials and methods are available as supporting material on Science Online.
14. F. Ness, P. Ferreira, B. S. Cox, M. F. Tuite, Mol. Cell. Biol. 22, 5593 (2002).
15. P. Satpute-Krishnan, S. X. Langseth, T. R. Serio, PLoS Biol. 5, e24 (2007).
16. T. Haslberger, B. Bukau, A. Mogk, Biochem. Cell Biol. 88, 63 (2010).
17. H. K. Edskes, V. T. Gray, R. B. Wickner, Proc. Natl. Acad. Sci. U.S.A. 96, 1498 (1999).
18. K. D. Allen et al., Genetics 169, 1227 (2005).
19. M. Crapeau, C. Marchal, C. Cullin, L. Maillet, Mol. Biol. Cell 20, 2286 (2009).
20. A. B. Salnikova, D. S. Kryndushkin, V. N. Smirnov, V. V. Kushnirov, M. D. Ter-Avanesyan, J. Biol. Chem. 280, 8808 (2005).
21. E. G. Rikhvanov, N. V. Romanova, Y. O. Chernoff, Prion 1, 217 (2007).
22. V. V. Kushnirov, A. B. Vishnevskaya, I. M. Alexandrov, M. D. Ter-Avanesyan, Prion 1, 179 (2007).
23. T. R. Serio, S. L. Lindquist, Annu. Rev. Cell Dev. Biol. 15, 661 (1999).
24. B. Cox, Heredity 20, 505 (1965).
25. L. J. Byrne et al., PLoS ONE 4, e4670 (2009).
26. R. Halfmann, S. Alberti, S. Lindquist, Trends Cell Biol. 20, 125 (2010).
27. A. K. Lancaster, J. P. Bardill, H. L. True, J. Masel, Genetics 184, 393 (2010).
28. J. R. Silveira et al., Nature 437, 257 (2005).
29. B. Frost, M. I. Diamond, Nat. Rev. Neurosci. 11, 155 (2010).
30. P. Brundin, R. Melki, R. Kopito, Nat. Rev. Mol. Cell Biol. 11, 301 (2010).
31. J. A. Pezza et al., Mol. Biol. Cell 20, 1068 (2009).
32. We thank N. Rhind, M. Duennwald, J. Sherley, and members of their groups for assistance with centrifugal elutriation, and the Center for Computation and Visualization, the Leduc Bioimaging Facility, and the Flow Cytometry and Sorting Facility at Brown University for instrumentation and the assistance of the respective support staffs. We thank J. Bender, J. Laney, M. Tuite, and members of the Serio and Laney labs for helpful discussions and comments on the manuscript. This research was supported by grants from NIH (GM069802 to T.R.S., GM085976 to A.D., GM089049 to S.S.S., AG034754 to C.K., and AG032818 to S.D.) and NSF/ADVANCE (0548311 to T.R.S.).