Neural stem cell differentiation in 2D and 3D microenvironments

IFMBE Proceedings

Volumn 32 IFMBE, Issue , 2010, Pages 422-425

  Ribeiro, A S ^a   Powell, E M ^b   Leach, J B ^a  

^a UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

1 integrin signaling; 3D culture; differentiation; Neural Stem Cells

Indexed keywords

3-D ENVIRONMENTS; 3D CULTURE; 3D SYSTEMS; CELL MATRIX; CELL MORPHOLOGY; CENTRAL NERVOUS SYSTEMS; CHAIN MIGRATION; CYTOSKELETAL; DIFFERENTIATION; ENVIRONMENTAL CUES; FUNCTIONAL RECOVERY; IMMUNOCYTOCHEMISTRY; IN-CELL; IN-VITRO; IN-VIVO; INDIVIDUAL CELLS; INTEGRINS; LIGAND ORGANIZATION; MATRIX; MICROENVIRONMENTS; MIGRATION PATTERNS; NERVE REPAIR; NEURAL STEM CELL; NEURAL STEM CELLS; NEURITES; NEURODEGENERATIVE DISORDERS; NEURONAL CELL; REGENERATIVE CAPACITY; SIGNALING PATHWAYS; TISSUE ENGINEERING APPLICATIONS;

BIOLOGICAL MATERIALS; FLOW CYTOMETRY; MORPHOLOGY; SIGNALING; STEM CELLS; THREE DIMENSIONAL; TISSUE ENGINEERING;

CELL CULTURE;

EID: 78049406768     PISSN: 16800737     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1007/978-3-642-14998-6_107     Document Type: Conference Paper

References (25)

1. Schmidt, C.E. & Leach, J.B. (2003) Neural tissue engineering: strategies for repair and regeneration. Annu Rev Biomed Eng 5, 293-347. (Pubitemid 40125315)
2. Ma, W. et al. (2004) CNS stem and progenitor cell differentiation into functional neuronal circuits in three-dimensional collagen gels. Exp Neurol 190, 276-88. (Pubitemid 39504987)
3. Martinez-Ramos, C. et al. (2008) Differentiation of postnatal neural stem cells into glia and functional neurons on laminin-coated polymeric substrates. Tissue Eng Part A 14, 1365-75.
4. Svendsen, C.N. et al. (1997) Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease. Exp Neurol 148, 135-46.
5. Kulbatski, I., Mothe, A.J., Nomura, H. & Tator, C.H. (2005) Endogenous and exogenous CNS derived stem/progenitor cell approaches for neurotrauma. Curr Drug Targets 6, 111-26.
6. Lepore, A.C. et al. (2006) Long-term fate of neural precursor cells following transplantation into developing and adult CNS. Neuroscience 139, 513-30.
7. Ma, W. et al. (2008) Reconstruction of functional cortical-like tissues from neural stem and progenitor cells. Tissue Eng Part A 14, 1673-86.
8. Park, K.I., Teng, Y.D. & Snyder, E.Y. (2002) The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue. Nat Biotechnol 20, 1111-7.
9. Freudenberg, U. et al. (2009) A star-PEG-heparin hydrogel platform to aid cell replacement therapies for neurodegenerative diseases. Biomaterials 30, 5049-60.
10. Bible, E. et al. (2009) The support of neural stem cells transplanted into stroke-induced brain cavities by PLGA particles. Biomaterials 30, 2985-94.
11. Cukierman, E., Pankov, R., Stevens, D.R. & Yamada, K.M. (2001) Taking cell-matrix adhesions to the third dimension. Science 294, 1708-12.
12. Paszek, M.J. et al. (2005) Tensional homeostasis and the malignant phenotype. Cancer Cell 8, 241-54.
13. Hoffman, R.M. (1993) To do tissue culture in two or three dimensions? That is the question. Stem Cells 11, 105-111.
14. Cullen, D.K., Lessing, M.C. & LaPlaca, M.C. (2007) Collagen-dependent neurite outgrowth and response to dynamic deformation in three-dimensional neuronal cultures. Ann Biomed Eng 35, 835-46.
15. Yamada, K.M., Pankov, R. & Cukierman, E. (2003) Dimensions and dynamics in integrin function. Braz J Med Biol Res 36, 959-66.
16. Cukierman, E., Pankov, R. & Yamada, K.M. (2002) Cell interactions with three-dimensional matrices. Curr Opin Cell Biol 14, 633-9.
17. Wozniak, M.A., Modzelewska, K., Kwong, L. & Keely, P.J. (2004) Focal adhesion regulation of cell behavior. Biochim Biophys Acta 1692, 103-19.
18. Geiger, B. (2001) Cell biology. Encounters in space. Science 294, 1661-3.
19. Lathia, J.D. et al. (2007) Patterns of laminins and integrins in the embryonic ventricular zone of the CNS. J Comp Neurol 505, 630-43.
20. Jacques, T.S. et al. (1998) Neural precursor cell chain migration and division are regulated through different beta1 integrins. Development 125, 3167-77.
21. O'Connor, S.M. et al. (2000) Primary neural precursor cell expansion, differentiation and cytosolic Ca(2+) response in three-dimensional collagen gel. J Neurosci Methods 102, 187-95.
22. Watanabe, K., Nakamura, M., Okano, H. & Toyama, Y. (2007) Establishment of three-dimensional culture of neural stem/progenitor cells in collagen Type-1 Gel. Restor Neurol Neurosci 25, 109-17.
23. Levenberg, S. et al. (2003) Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds. Proc Natl Acad Sci U S A 100, 12741-6.
24. Reynolds, B.A. & Weiss, S. (1992) Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255, 1707-10.
25. Bez, A. et al. (2003) Neurosphere and neurosphere-forming cells: morphological and ultrastructural characterization. Brain Res 993, 18-29.