Androgen-mediated down-regulation of CYP1A subfamily genes in the pig liver

Journal of Endocrinology

Volumn 207, Issue 2, 2010, Pages 203-211

  Kojima, Misaki ^a   Sekimoto, Masashi ^b   Degawa, Masakuni ^b  

^a NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES   (Japan)

^b UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 1A; CYTOCHROME P450 1A2; MESSENGER RNA; TESTOSTERONE; TESTOSTERONE PROPIONATE;

ANIMAL TISSUE; ARTICLE; CASTRATION; CONTROLLED STUDY; CORRELATIONAL STUDY; DOWN REGULATION; ENZYME ACTIVITY; EXPERIMENTAL PIG; FEMALE; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION; LIVER; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SEX DIFFERENCE; TESTOSTERONE BLOOD LEVEL; WESTERN BLOTTING;

AGING; ANDROGENS; ANIMALS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MALE; MICROSOMES, LIVER; MULTIGENE FAMILY; RNA, MESSENGER; SEX CHARACTERISTICS; SWINE; TESTOSTERONE PROPIONATE;

EID: 78049388643     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-10-0160     Document Type: Article

References (43)

1. Agrawal AK & Shapiro BH 2001 Intrinsic signals in the sexually dimorphic circulating growth hormone profiles of the rat. Molecular and Cellular Endocrinology 173 167-181. (doi:10.1016/S0303-7207(00)00401-9)
2. Androutsopoulos VP, Tsatsakis AM & Spandidos DA 2009 Cytocrome P450 CYP1A1: wider roles in cancer progression and prevention. BMC Cancer 9 187. (doi:10.1186/1471-2407-9-187)
3. Arbona JR, Marple DN, Russell RW, Rahe CH, Mulvaney DR & Sartin JL 1988 Secretory patterns and metabolic clearance rate of porcine growth hormone in swine selected for growth. Journal of Animal Science 66 3068-3072.
4. Burke MD, Thompson S, Elcombe CR, Halpert J, Haaparanta T & Mayer RT 1985 Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochrome P-450. Biochemical Pharmacology 34 3337-3345. (doi:10.1016/0006-2952(85)90355-7)
5. Burke MD, Thompson S, Weaver RJ, Wolf CR & Mayer RT 1994 Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver. Biochemical Pharmacology 48 923-936. (doi:10.1016/0006-2952(94)90363-8)
6. Conney AH 1982 Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G.H.A. Clowes memorial lecture. Cancer Research 42 4875-4917.
7. Corchero J, Pimprale S, Kimura S & Gonzalez FJ 2001 Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation. Pharmacogenetics 11 1-6. (doi:10.1097/00008571-200102000-00001)
8. Davis SL, Ohlson DL, Klindt J & Anfinson MS 1977 Episodic growth hormone secretory patterns in sheep: relationship to gonadal steroid hormones. American Journal of Physiology-Endocrinology and Metabolism 233 E519-E523.
9. Degawa M, Kojima M, Hishinuma T & Hashimoto Y 1985 Sex-dependent induction of hepatic enzymes for mutagenic activation of a tryptophan pyrolysate component, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole, by feeding in mice. Cancer Research 45 96-102.
10. Degawa M, Yamaya C & Hashimoto Y 1988 Hepatic cytochrome P-450 isozymes induced by dietary carcinogenic aromatic amines preferentially in female mice of DBA/2 and other strains. Carcinogenesis 9 567-571. (doi:10.1093/carcin/9.4.567)
11. Degawa M, Miura S & Hashimoto Y 1990 Androgen-dependent renal microsomal cytochrome P-450 responsible for N-hydroxylation and mutagenic activation of 3-methoxy-4-aminoazobenzene in the BALB/c mouse. Cancer Research 50 2729-2733.
12. Degawa M, Hanaki K & Sekimoto M 2006 A hepatocarcinogenic tryptophan-pyrolyzate component, Trp-P-1, decreases serum total testosterone level and induces hepatic Cyp1a2 in male mice. Cancer Science 97 32-37. (doi:10.1111/j.1349-7006.2006.00140.x)
13. Denison MS & Nagy SR 2003 Activation of the aryl hydrocarbopn receptor by structurally diverse exogenous and endogenous chemicals. Annual Review of Pharmacology and Toxicology 43 309-334. (doi:10.1146/annurev.pharmtox. 43.100901.135828)
14. Dubreuil P, Couture PY, Lapierre H, Petotclerc D, Morisset J, Gaudreau P & Brazeau P 1989 Castration and teatosterone effects on endogenous and somaticinin-induced growth hormone relaease in intact and castrated male pigs. Domestic Animal Endocrinology 6 15-24. (doi:10.1016/0739-7240(89)90003-9)
15. Graham MJ & Lake BG 2008 Induction of drug metabolism: species differences and toxicological relevance. Toxicology 254 184-191. (doi:10.1016/j.tox.2008.09.002)
16. Guengerich FP 2003 Cytochromes P450, drugs, and diseases. Molecular Interventions 3 194-204. (doi:10.1124/mi.3.4.194)
17. Hankinson O 1995 The aryl hydrocarbon receptor complex. Annual Review of Pharmacology and Toxicology 35 307-340. (doi:10.1146/annurev.pa.35.040195. 001515)
18. Hashimoto Y, Degawa M, Kojima M & Hishinuma T 1982 Induction of carcinogen activation enzymes by feeding of a carcinogenic tryptophan pyrolysate correlates to sex difference in the carcinogenesis of the mouse. Gann 73 508-510.
19. Honkakoski P, Kojo A & Lang MA 1992 Regulation of the mouse liver cytochrome P450 2B subfamily by sex hormones and phenobarbital. Biochemical Journal 285 979-983.
20. Imaoka S, Hiroi T, Tamura Y, Yamazaki H, Shimada T, Komori M, Degawa M & Funae Y 1995 Mutagenic activation of 3-methoxy-4-aminoazobenzene by mouse renal cytochrome P450 CYP4B1: cloning and characterization of mouse CYP4B1. Archives of Biochemistry and Biophysics 321 255-262. (doi:10.1006/abbi.1995. 1393)
21. Ishii K, Yamazoe Y, Kamataki T & Kato R 1981 Metabolic activation of glutamic acid pyrolysis products, 2-amino-6-dimethyldipyrido[1,2-a:3′, 2′-d]imidazole and 2-amino-dipyrido[1,2-a:3′,2′-d]imidazole, by purified cytochrome P-450. Chemico-Biological Interactions 38 1-13. (doi:10.1016/0009-2797(81)90149-6)
22. Kamataki T, Maeda K, Yamazoe Y, Matsuda N, Ishii K & Kato R 1983 A high-spin form of cytochrome P-450 highly purified from polychlorinated biphenyl-treated rats. Catalytic characterization and immunochemical quantitation in liver microsomes. Molecular Pharmacology 23 146-155.
23. Kleman M, Overvik E, Mason G & Gustafsson J-A 1990 Effects of the food mutagens MeIQx and PhIP on the expression of cytochrome P450IA proteins in various tissues of male and female rats. Carcinogenesis 11 2185-2189. (doi:10.1093/carcin/11.12.2185)
24. Kojima M & Morozumi T 2004 Cloning of six full-length cDNAs encoding pig cytochrome P450 enzymes and gene expression of these enzymes in the liver and kidney. Journal of Health Science 50 518-529. (doi:10.1248/jhs.50.518)
25. Kojima M, Sekimoto M & Degawa M 2008 A novel gender-related difference in the constitutive expression of hepatic cytochrome P4501A subfamily enzymes in Meishan pigs. Biochemical Pharmacology 75 1076-1082. (doi:10.1016/j.bcp.2007.10.030)
26. Link K, Blizzard RM, Evans WS, Kaiser DL, Parker MW & Rogol AD 1986 The effect of androgens on the pulsatile release and the twenty-four-hour mean concentration of growth hormone in peripubertal males. Journal of Clinical Endocrinology and Metabolism 62 159-164. (doi:10.1210/jcem-62-1-159)
27. Lowry OH, Rosebrough NJ, Farr AL & Randall RJ 1951 Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193 265-275.
28. Messina A, Chirulli V, Gervasi PG & Longo V 2008 Purification, molecular cloning, heterologus expression and characterization of pig CYP1A2. Xenobiotica 38 1453-1470. (doi:10.1080/00498250802474437)
29. Mode A & Gustafsson J-A 2006 Sex and the liver - a journey through five decades. Drug Metabolism Reviews 38 197-207. (doi:10.1080/ 03602530600570057)
30. Murray M 2006 Altered CYP expression and function in response to dietary factors: potential roles in disease pathogenesis. Current Drug Metabolism 7 67-81. (doi:10.2174/138920006774832569)
31. Myers MJ, Farrell DE, Howard KD & Kawalek JC 2001 Identification of multiple constitutive and inducible hepatic cytochrome P450 enzymes in market weight swine. Drug Metabolism and Disposition 29 908-915.
32. Nelson DR, Koymans L, Kamataki T, Stegeman JJ, Feyereisen R, Waxman DJ, Waterman MR, Gotoh O, Conn MJ, Estabrook RW et al. 1996 P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 6 1-42. (doi:10.1097/00008571-199602000-00002)
33. Nukaya M & Bradfield CA 2009 Conserved genomic structure of the Cyp1a1 and Cyp1a2 loci and their dioxin responsive elements cluster. Biochemical Pharmacology 77 654-659. (doi:10.1016/j.bcp.2008.10.026)
34. Omiecinski CJ, Remmel RP & Hosagrahara VP 1999 Concise review of the cytochrome P450s and their roles in toxicology. Toxicological Sciences 48 151-156. (doi:10.1093/toxsci/48.2.151)
35. Parkinsin A, Mudra DR, Johnson C, Dwyer A & Carroll KM 2004 The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes. Toxicology and Applied Pharmacology 199 193-209. (doi:10.1016/j.taap.2004.01.010)
36. Sanada N, Gotoh Y, Shimazawa R, Klinge CM & Kizu R 2009 Repression of activated aryl hydrocarbon receptor-induced transcriptional activation by 5α-dihydrotestosterone in human prostate cancer LNCaP and human breast cancer T47D cells. Journal of Pharmacological Sciences 109 380-387. (doi:10.1254/jphs.08328FP)
37. Shimada T 2006 Xenobiotic-metabolizing enzymes involved in activation and detoxification of carcinogenic polycyclic aromatic hydrocarbons. Drug Metabolism and Pharmacokinetics 21 257-276. (doi:10.2133/dmpk.21.257)
38. Shimizu Y, Nakatsuru Y, Ichinose M, Takahashi Y, Kume H, Mimura J, Fujii-Kuriyama Y & Ishikawa T 2000 Benzo[a]pyrene carcinogenicity is lost lacking the aryl hydrocarbon receptor. PNAS 97 779-782. (doi:10.1073/pnas.97.2. 779)
39. Somana R, Visessuwan S, Samridtong A & Holland RC 1978 Effect of neonatal androgen treatment and orchidectomy on pituitary levels of growth hormone in the rat. Journal of Endocrinology 79 399-400. (doi:10.1677/joe.0. 0790399)
40. Swindle MM & Smith AC 1998 Comparative anatomy and physiology of the pig. Scandinavian Journal of Laboratory Animal Science 25 (Suppl 1) 11-22.
41. Waxman DJ & Holloway MG 2009 Sex differences in the expression of hepatic drug metabolizing enzymes. Molecular Pharmacology 76 215-228. (doi:10.1124/mol.109.056705)
42. Zamaratskaia G, Zlabek V, Chen G & Madej A 2009 Modulation of porcine cytochrome P450 enzymes activities by surgical castration and immunocastration. Animal 3 1124-1132. (doi:10.1017/S1751731109004510)
43. Zamaratskaia G, Zlabek V, Ropstad E, Tajet H & Andresen O 2010 Hepatic ethoxy-, methoxy- and pentoxyresorfin O-dealkylase activities in Landrace and Duroc pigs stimulated with hCG. Reproduction in Domestic Animals (In Press). (doi: 10.1111/j.1439-0531.2009.01553.x)