A hepatocarcinogenic trytophan-pyrolyzate component, Trp-P-1, decreases serum total testosterone level and induces hepatic Cyp1a2 in male mice

Cancer Science

Volumn 97, Issue 1, 2006, Pages 32-37

  Degawa, Masakuni ^a   Hanaki, Koji ^a   Sekimoto, Masashi ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 1,4 DIMETHYL 5H PYRIDO[4,3 B]INDOLE; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ANDROGEN; APOPROTEIN; CYTOCHROME P450 1A2; MESSENGER RNA; O DEMETHYLASE; RESORUFIN DERIVATIVE; STEROID 17ALPHA MONOOXYGENASE; TESTOSTERONE; CARBOLINE DERIVATIVE; CARCINOGEN; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); TRP-P-1;

ANDROGEN SYNTHESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CHEMICAL CARCINOGENESIS; CHOLESTEROL SIDE CHAIN CLEAVAGE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; LIVER CANCER; LIVER MICROSOME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TESTOSTERONE BLOOD LEVEL; WESTERN BLOTTING; ANIMAL; BLOOD; BODY WEIGHT; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; LIVER; METABOLISM; ORGAN SIZE; TESTIS;

3-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; APOPROTEINS; BODY WEIGHT; CARBOLINES; CARCINOGENS; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; CYTOCHROME P-450 CYP1A2; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIVER; MALE; MICE; ORGAN SIZE; RNA, MESSENGER; STEROID 17-ALPHA-HYDROXYLASE; TESTIS; TESTOSTERONE;

EID: 32944470515     PISSN: 13479032     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2006.00140.x     Document Type: Article

References (34)

1. Doll R. Nature and nurture: possibilities for cancer control. Carcinogenesis 1996; 17: 177-84.
2. Skog KI, Johansson MA, Jagerstad MI. Carcinogenic heterocyclic amines in model systems and cooked foods: a review on formation, occurrence and intake. Food Chem Toxicol 1998; 36: 879-96.
3. Eisenbrand G, Tang W. Food-borne heterocyclic amines. Chemistry, formation, occurrence and biological activities. A literature review. Toxicology 1993; 84: 1-82.
4. Sugimura T. Overview of carcinogenic heterocyclic amines. Mutat Res 1997; 376: 211-19.
5. Bogen KT. Cancer potencies of heterocyclic amines found in cooked foods. Food Chem Toxicol 1994; 32: 505-15.
6. Sugimura T, Kawachi T, Nagao M et al. Mutagenic principles in tryptophan and phenylalanine pyrolysis products. Proc Jap Acad 1977; 53: 58-61.
7. Hashimoto Y, Shudo K, Okamoto T. Activation of a mutagen, 3-amino-1-methyl-5H-pyrido[4,3-b]indole: identification of 3-hydroxy-amino-1-methyl-pyrido[4,3-b]indole and its reaction with DNA. Biochem Biophys Res Commun 1980; 96: 355-62.
8. Ishii K, Yamazoe Y, Kamataki T, Kato R. Metabolic activation of glutamic acid pyrolysis products, 2-amino-6-methyldipyrido[1,2-a:3′,2′-d]imidazole and 2-amino-dipyrido[1,2-a:3′,2′-d]imidazole, by purified cytochrome P-450. Chem Biol Interact 1981; 38: 1-13.
9. Miller JA. Carcinogenesis by chemicals: an overview - G. H. A. Clowes memorial lecture. Cancer Res 1970; 30: 559-76.
10. Odashima S, Hashimoto Y. Carcinogenicity and target organs of methoxyl derivatives of 4-aminoazobenzene in rats. I. 3-Methoxy- and 3,4′-dimethoxy-4-aminoazobenzene. Gann 1968; 59: 131-43.
11. Watanabe HK, Hashimoto Y, Abe I, Sato H. Carcinogenicities of 3-methoxy-4-aminoazobenzesne, N-hydroxy-3-methoxy-4-aminoazobenzene and related azo dyes in the mouse. Gann 1982; 73: 136-40.
12. Andervont HB, Dunn TB. Effect of castration and sex hormones on the induction of tumors in mice with O-amino-azotoluene. J Natl Cancer Inst 1947; 7: 455-61.
13. Matsukura N, Kawachi T, Morino K, Ohgaki H, Sugimura T, Takayama S. Carcinogenicity in mice of mutagenic compounds from a tryptophan pyrolyzate. Science 1981; 213: 346-7.
14. Hashimoto Y, Degawa M, Kojima M, Hishinuma T. Induction of carcinogen activation enzymes by feeding of a carcinogenic tryptophan pyrolysate correlates to sex difference in the carcinogenesis of the mouse. Gann 1982; 73: 508-10.
15. Degawa M, Kojima M, Hashimoto Y. Species difference between rats and mice in activities of enzymes activating aromatic amines: effect of dietary 3-methoxy-4-aminoazobenzene. Gann 1984; 75: 966-75.
16. Degawa M, Kojima M, Hishinuma T, Hashimoto Y. Sex-dependent induction of hepatic enzymes for mutagenic activation of a tryptophan pyrolysate component, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]-indole, by feeding in mice. Cancer Res 1985; 45: 96-102.
17. Degawa M, Hishinuma T, Yoshida H, Hashimoto Y. Species, sex and organ differences in induction of a cytochrome P-450 isozyme responsible for carcinogen activation: effects of dietary hepatocarcinogenic tryptophan pyrolysate components in mice and rats. Carcinogenesis 1987; 8: 1913-18.
18. Degawa M, Tanimura S, Agatsuma T, Hashimoto Y. Hepatocarcinogenic heterocyclic aromatic amines that induce cytochrome P-448 isozymes, mainly cytochrome P-448H (P-450IA2), responsible for mutagenic activation of the carcinogens in rat liver. Carcinogenesis 1989; 10: 1119-22.
19. Degawa M, Yamaya C, Hashimoto Y. Hepatic cytochrome P-450 isozymes induced by dietary carcinogenic aromatic amines preferentially in female mice of DBA/2 and other strains. Carcinogenesis 1988; 9: 567-71.
20. Degawa M, Namiki M, Yoshimoto N et al. Constitutive expression of cytochrome P450 genes in newly established rat hepatic cell lines. J Biochem 2003; 133: 825-31.
21. Sekimoto M, Iwamoto M, Miyajima S, Nemoto K, Degawa M. Establishment of a rat hepatic cell line, KanR2-XL8, for a reporter gene assay of aryl hydrocarbon receptor ligands. J Health Sci 2004; 50: 530-6.
22. Greco TL, Payne AH. Ontogeny of expression of the genes for steroidogenic enzymes P450 side-chain cleavage, 3β-hydroxysteroid dehydrogenase, P450 17α-hydroxylase/C17-20 lyase, and P450 aromatase in fetal mouse gonads. Endocrinology 1994; 135: 262-8.
23. Seree EM, Villard PH, Re JL et al. High inducibility of mouse renal CYP2E1 gene by tobacco smoke and its possible effect on DNA single strand breaks. Biochem Biophys Res Commun 1996; 219: 429-34.
24. Wool IG, Chan YL, Paz V, Olvera J. The primary structure of rat ribosomal proteins: the amino acid sequences of L27a and L28 and corrections in the sequences of S4 and S12. Biochim Biophys Acta 1990; 1050: 69-73.
25. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-75.
26. Burke MD, Thompson S, Weaver RJ, Wolf CR, Mayer RT. Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver. Biochem Pharmacol 1994; 48: 923-36.
27. Burke MD, Thompson S, Elcombe CR, Halpert J, Haaparanta T, Mayer RT. Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450. Biochem Pharmacol 1985; 34: 3337-45.
28. Konno Y, Nemoto K, Degawa M. Induction of hepatic cytochrome P450s responsible for the metabolism of xenobiotics by nicardipine and other calcium channel antagonists in the male rat. Xenobiotica 2003; 33: 119-29.
29. Hashimoto Y, Masuko T, Itoh K et al. Monoclonal antibodies against a high spin form of rat cytochrome P-448. Biochem Biophys Res Commun 1985; 131: 600-6.
30. Payne AH, Hales DB. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev 2004; 25: 947-70.
31. Cooper KO, Reik LM, Jayyosi Z et al. Regulation of two members of the steroid-inducible cytochrome P450 subfamily (3A) in rats. Arch Biochem Biophys 1993; 301: 345-54.
32. Shapiro BH, Pampori NA, Lapenson DP, Waxman DJ. Growth hormone-dependent and -independent sexually dimorphic regulation of phenobarbital-induced hepatic cytochromes P450 2B1 and 2B2. Arch Biochem Biophys 1994; 312: 234-9.
33. Larsen MC, Brake PB, Parmar D, Jefcoate CR. The induction of five rat hepatic P450 cytochromes by phenobarbital and similarly acting compounds is regulated by a sexually dimorphic, dietary-dependent endocrine factor that is highly strain specific. Arch Biochem Biophys 1994; 315: 24-34.
34. Agrawal AK, Shapiro BH. Phenobarbital induction of hepatic CYP2B1 and CYP2B2: pretranscriptional and post-transcriptional effects of gender, adult age, and phenobarbital dose. Mol Pharmacol 1996; 49: 523-31.