Hepatic ethoxy-, methoxy- and pentoxyresorufin O-dealkylase activities in landrace and duroc pigs stimulated with hCG

Reproduction in Domestic Animals

Volumn 45, Issue 6, 2010, Pages

  Zamaratskaia, G ^a   Zlabek, V ^a,b   Ropstad, E ^c   Tajet, H ^d   Andresen, O ^c  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b UNIVERSITY OF SOUTH BOHEMIA   (Czech Republic)

^c NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

^d Norsvin   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS ACTING ON THE GENITAL SYSTEM; CHORIONIC GONADOTROPIN; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 2B1; METHOXYRESORUFIN O DEMETHYLASE; METHOXYRESORUFIN-O-DEMETHYLASE; OXAZINE DERIVATIVE; RESORUFIN;

ANIMAL; ARTICLE; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; KINETICS; LIVER; MALE; METABOLISM; SWINE;

ANIMALS; CHORIONIC GONADOTROPIN; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; KINETICS; LIVER; MALE; OXAZINES; REPRODUCTIVE CONTROL AGENTS; SWINE;

SUIDAE; SUS;

EID: 78049367452     PISSN: 09366768     EISSN: 14390531     Source Type: Journal    
DOI: 10.1111/j.1439-0531.2009.01553.x     Document Type: Article

References (18)

1. Andresen Ø, 1975: 5α-Androstenone in peripheral plasma of pigs, diurnal variation in boars, effects of intravenous HCG administration and castration. Acta Endocrinol (Copenh) 78, 385-391.
2. Bonneau M, Meusy-Dessolle N, Léglise PC, Claus R, 1982: Relationships between fat and plasma androstenone and plasma testosterone in fatty and lean young boars during growth and after hCG stimulation. Acta Endocrinol (Copenh) 101, 119-128.
3. Carlström K, Malmfors B, Lundström K, Edqvist LE, Gahne B, 1975: The effect of HCG on blood plasma levels of 5α-androstenone and testosterone in the boar. Swed J Agric Res 5, 15-21.
4. Doran E, Whittington FW, Wood JD, McGivan JD, 2002: Cytochrome P450IIE1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes. Chem Biol Interact 140, 81-92.
5. Gillberg M, Skaanild MT, Friis C, 2006: Regulation of gender-dependent CYP2A expression in pigs: involvement of androgens and CAR. Basic Clin Pharmacol Toxicol 98, 480-487.
6. Kojima M, Sekimoto M, Degawa M, 2008: A novel gender-related difference in the constitutive expression of hepatic cytochrome P4501A subfamily enzymes in Meishan pigs. Biochem Pharmacol 75, 1076-1082.
7. Marvasi L, Zaghini A, Gervasi PG, Vaccaro E, Chirulli V, 2006: Induction of cytochrome P450 1A by β-naphto-flavon within the pig liver and central nervous system. Vet Res Commun 30, 333-336.
8. Messina A, Nannelli A, Fiorio R, Longo V, Gervasi PG, 2009: Expression and inducibility of CYP1A1, 1A2, 1B1 by beta-naphthoflavone and CYP2B22, 3A22, 3A29, 3A46 by rifampicin in the respiratory and olfactory mucosa of pig. Toxicology 260, 47-52.
9. Moe M, Grindflek E, Doran O, 2007: Expression of 3beta-hydroxysteroid dehydrogenase, cytochrome P450-c17, and sulfotransferase 2B1 proteins in liver and testis of pigs of two breeds: relationship with adipose tissue androstenone concentration. J Anim Sci 85, 2924-2931.
10. Skaanild MT, Friis C, 1999: Cytochrome P450 sex differences in minipigs and conventional pigs. Pharmacol Toxicol 85, 174-180.
11. Waxman DJ, 1996: Steroid hormones and other physiologic regulators of liver cytochromes P450: Metabolic ractions and regulatory pathways. Adv Mol Cell Biol 14, 341-374.
12. Zamaratskaia G, Zlabek V, 2009: EROD and MROD as markers of cytochrome P450 1A activities in hepatic microsomes from entire and castrated male pigs. Sensors 9, 2134-2147.
13. Zamaratskaia G, Squires EJ, Babol J, Andersson HK, Andersson K, Lundström K, 2005: Relationship between the activities of cytochromes P4502E1 and P4502A6 and skatole content in fat in entire male pigs fed with and without raw potato starch. Livest Prod Sci 95, 83-88.
14. Zamaratskaia G, Chen G, Lundström K, 2006: Effects of sex, weight, diet and hCG administration on levels of skatole and indole in the liver and hepatic activities of cytochromes P4502E1 and P4502A6 in pigs. Meat Sci 72, 331-338.
15. Zamaratskaia G, Gilmore WJ, Lundström K, Squires EJ, 2007a: Effect of testicular steroids on catalytic activities of cytochrome P450 enzymes in porcine liver microsomes. Food Chem Toxicol 45, 676-681.
16. Zamaratskaia G, Lou Y, Chen G, Andresen Ø, Lundström K, Squires EJ, 2007b: Effect of hCG stimulation on plasma androstenone concentrations and cytochrome b5 (CYPB5) levels in testicular tissue. Reprod Domest Anim 42, 105-108.
17. Zamaratskaia G, Oskam IC, Ropstad E, Tajet H, Andresen Ø, 2008: Effect of hCG stimulation on hepatic activities of cytochrome P4502E1 and P4502A in entire male pigs. Reprod Domest Anim 43, 147-152.
18. Zamaratskaia G, Zlabek V, Chen G, Madej A, 2009: Modulation of porcine cytochrome P450 enzyme activities by surgical castration and immunocastration. Animal 3, 1124-1132.