Hepatitis B spliced protein (HBSP) generated by a spliced hepatitis B virus RNA participates in abnormality of fibrin formation and functions by binding to fibrinogen γ chain

Journal of Medical Virology

Volumn 82, Issue 12, 2010, Pages 2019-2026

  Chen, Jin Yan ^a   Chen, Wan Nan ^a   Liu, Ling Ling ^a   Lin, Wan Song ^a   Jiao, Bo Yan ^a   Wu, Yun Li ^a   Lin, Jian Yin ^a   Lin, Xu ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Fibrinogen; Hepatitis B virus; RNA splicing

Indexed keywords

BLOOD CLOTTING FACTOR 13A; FIBRIN; FIBRINOGEN; FIBRINOGEN GAMMA; HEPATITIS B SPLICED PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA;

ADULT; AMINO TERMINAL SEQUENCE; ARTICLE; FIBRIN FORMATION; FIBRIN POLYMERIZATION; HEPATITIS B; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; NORMAL HUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION;

ADULT; AMINO ACID SEQUENCE; CELL LINE, TUMOR; FACTOR XIIIA; FIBRIN; FIBRINOGEN; GENE LIBRARY; HEPATITIS B VIRUS; HUMANS; LIVER; MOLECULAR SEQUENCE DATA; PLATELET ADHESIVENESS; PLATELET AGGREGATION; RNA SPLICING; TWO-HYBRID SYSTEM TECHNIQUES; VIRAL PROTEINS;

HEPATITIS B VIRUS; MAMMALIA;

EID: 78049386534     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.21918     Document Type: Article

References (21)

1. Bradley DW. 1999. Hepatitis viruses: Their role in human cancer. Proc Assoc Am Physicians 111: 588-593.
2. Fuss C, Palmaz JC, Sprague EA. 2001. Fibrinogen: Structure, function, and surface interactions. J Vasc Interv Radiol 12: 677-682.
3. Ganem D, Varmus HE. 1987. The molecular biology of the hepatitis B viruses. Annu Rev Biochem 56: 651-693.
4. Günther S, Li BC, Miska S, Krüger DH, Meisel H, Will H. 1995. A novel method for efficient amplification of whole hepatitis B virus genomes permits rapid functional analysis and reveals deletion mutants in immunosuppressed patients. J Virol 69: 5437-5444.
5. Günther S, Sommer G, Iwanska A, Will H. 1997. Heterogeneity and common features of defective hepatitis B virus genomes derived from spliced pregenomic RNA. Virology 238: 363-371.
6. Hunt CM, McGill JM, Allen MI, Condreay LD. 2000. Clinical relevance of hepatitis B viral mutations. Hepatology 31: 1037-1044.
7. Jiroušková M, Smyth SS, Kudryk B, Coller BS. 2001. A hamster antibody to the mouse fibrinogen γ chain inhibits platelet-fibrinogen interactions and FXIIIa-mediated fibrin cross-linking, and facilitates thrombolysis. Thromb Haemost 86: 1047-1056.
8. Kujovich JL. 2005. Hemostatic defects in end stage liver disease. Crit Care Clin 21: 563-587.
9. Lei S, Pulakat L, Gavini N. 1999. Genetic analysis of nif regulatory genes by utilizing the yeast two-hybrid system detected formation of a NifL-NifA complex that is implicated in regulated expression of nif genes. J Bacteriol 181: 6535-6539.
10. Liu CZ, Cheng HJ, Chang LY. 2008. A new feasible method for fibrinogen purification based on the affinity of Staphylococcus aureus clumping factor A to fibrinogen. Protein Expr Purif 61: 31-35.
11. Mancini-Bourging M, Bayard F, Soussan P, Deng Q, Lone YC, Kremsdorf D, Michel ML. 2007. Hepatitis B virus splice-generated protein induces T-cell responses in HLA-transgenic mice and hepatitis B virus-infected patients. J Virol 81: 4963-4972.
12. Mosesson MW. 2002. Fibrinogen c chain functions. J Thromb Haemost 1: 231-238.
13. Mosesson MW, Siebenlist KR, Amrani DL, DiOrio JP. 1989. Identification of covalently linked trimeric and tetrameric D domains in crosslinked fibrin. Proc Natl Acad Sci USA 86: 1113-1117.
14. Pratt KP, Côté HCF, Chung DW, Stenkamp RE, Davie EW. 1997. The primary fibrin polymerization pocket, three-dimensional structure of a 30-kDa C-terminal g chain fragment complexed with the peptide gly-pro-arg-pro. Proc Natl Acad Sci USA 94: 7176-7181.
15. Radosavljevic MP. 2007. Review article: Coagulation disorders in chronic liver disease. Aliment Pharmacol Ther 26: 21-28.
16. Rosmorduc O, Petit MA, Pol S, Capel F, Bortolotti F, Berthelot P, Brechot C, Kremsdorf D. 1995. In vivo and in vitro expression of defective hepatitis B virus particles generated by spliced hepatitis B virus RNA. Hepatology 22: 10-19.
17. Scheiner T, Jirousova M, Nagaswami C, Coller BS, Weisel JW. 2003. A monoclonal antibody to the fibrinogen γ-chain alters fibrin clot structure and its properties by producing shot, thin fibers arranged in bundles. J Throm Haemost 1: 2594-2602.
18. Sinha AK, Colman RW. 1978. Prostaglandin E1 inhibits platelet aggregation by a pathway independent of adenosine 3', 5'-monophosphate. Science 200: 202-203.
19. Soussan P, Garreau F, Zylberberg H, Ferray C, Brechot C, Kremsdorf D. 2000. In vivo expression of a new hepatitis B virus protein encoded by a spliced RNA. J Clin Invest 105: 55-60.
20. Soussan P, Tuveri R, Nalpas B, Garreau F, Zavala F, Masson A, Pol S, Brechot C, Kremsdorf D. 2003. The expression of hepatitis B spliced protein (HBSP) encoded by a spliced hepatitis B virus RNA is associated with viral replication and liver fibrosis. J Hepatol 38: 343-348.
21. Taubenfeld SM, Song Y, Sheng D, Ball EL, Matsueda GR. 1995. A monoclonal antibody against a peptide sequence of fibrinogen gamma chain acts as an inhibitor of factor XIII-mediated crosslinking of human fibrin. Thromb Haemost 74: 923-927.