Synthesis, determination of absolute configuration, and biological evaluation of spiro-fused thiadiazoline inhibitors of kinesin spindle protein (KSP)

Tetrahedron Letters

Volumn 51, Issue 48, 2010, Pages 6236-6239

  Angeles, Angie R ^a   Yang, Liping ^a   Dai, Chaoyang ^a   Brunskill, Andrew ^a   Basso, Andrea D ^a   Siddiqui, M Arshad ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Dihydropyrazole; Kinesin spindle protein; Microtubule targeting drugs; Structure activity relationships; Thiadiazoline

Indexed keywords

1,3,4 THIADIAZOLINE DERIVATIVE; ANTINEOPLASTIC AGENT; KINESIN SPINDLE PROTEIN INHIBITOR; THIOSEMICARBAZONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL REACTION; CYCLIZATION; DRUG BIOAVAILABILITY; DRUG DETERMINATION; DRUG STRUCTURE; DRUG SYNTHESIS; MICHAEL ADDITION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

EID: 78049358943     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.09.066     Document Type: Article

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