Thermodynamic stability and folding kinetics of the major G-quadruplex and its loop isomers formed in the nuclease hypersensitive element in the human c-Myc promoter: Effect of loops and flanking segments on the stability of parallel-stranded intramolecular G-quadruplexes

Biochemistry

Volumn 49, Issue 43, 2010, Pages 9152-9160

  Hatzakis, Emmanuel ^a   Okamoto, Keika ^a   Yang, Danzhou ^a,b  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AVERAGE DIFFERENCE; BROAD SPECTRUM; CAPPING STRUCTURE; DRUG-TARGETING; FOLDING KINETICS; G-QUADRUPLEX STRUCTURE; G-QUADRUPLEXES; HUMAN CANCER; KINETIC PROPERTIES; KINETIC STUDY; NUCLEASE HYPERSENSITIVITY ELEMENTS; OVER-EXPRESSION; TRANSCRIPTIONAL CONTROL; TRANSCRIPTIONAL SILENCING; TRANSCRIPTIONALLY ACTIVE;

DNA SEQUENCES; THERMODYNAMIC STABILITY; THERMODYNAMICS;

ISOMERS;

DEOXYRIBONUCLEASE; GUANINE QUADRUPLEX; MYC PROTEIN; POTASSIUM ION;

ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; DNA STRAND; ISOMER; MOLECULAR STABILITY; ONCOGENE C MYC; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; THERMOSTABILITY;

ENDONUCLEASES; G-QUADRUPLEXES; HUMANS; KINETICS; NUCLEIC ACID CONFORMATION; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-MYC; REGULATORY SEQUENCES, NUCLEIC ACID; THERMODYNAMICS; TRANSITION TEMPERATURE;

EID: 78049296602     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100946g     Document Type: Article

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