Prevention of primary graft dysfunction in lung transplantation by N-acetylcysteine after prolonged cold ischemia

Journal of Heart and Lung Transplantation

Volumn 29, Issue 11, 2010, Pages 1293-1301

  Inci, Ilhan ^a   Erne, Barbara ^a   Arni, Stephan ^a   Jungraithmayr, Wolfgang ^a   Inci, Demet ^b   Hillinger, Sven ^a,b   Vogt, Peter ^a   Leskosek, Boris ^a   Weder, Walter ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

Author keywords

cold ischemia; ischemia reperfusion injury; lung transplantation; N acetylcysteine; primary graft dysfunction

Indexed keywords

ACETYLCYSTEINE; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; LEUKOCYTE ELASTASE; MESSENGER RNA; NITRITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL LEVEL; COLD ISCHEMIA; CONTINUOUS INFUSION; CONTROLLED STUDY; CRYOPRESERVATION; ERYTHROCYTE; GENE EXPRESSION REGULATION; GRAFT RECIPIENT; LUNG ARTERY PRESSURE; LUNG COMPLIANCE; LUNG EXTRAVASCULAR FLUID; LUNG LAVAGE; LUNG PERFUSION; LUNG PRESSURE; LUNG TRANSPLANTATION; NONHUMAN; ORGAN DONOR; OXYGENATION; PORCINE ADENOVIRUS; PRIMARY GRAFT DYSFUNCTION; PRIORITY JOURNAL; PROTEIN CONTENT; REPERFUSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE LEVEL;

ACETYLCYSTEINE; ANIMALS; COLD ISCHEMIA; FREE RADICAL SCAVENGERS; GLUTATHIONE; GRAFT SURVIVAL; LUNG; LUNG TRANSPLANTATION; MODELS, ANIMAL; NF-KAPPA B; NITRIC OXIDE; PRIMARY GRAFT DYSFUNCTION; SWINE;

EID: 78049257746     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.healun.2010.06.017     Document Type: Article

References (38)

1. J.C. Lee, and J.D. Christie Primary graft dysfunction Proc Am Thorac Soc 6 2009 39 46
2. P. Aurora, L.B. Edwards, and J. Christie Registry of the International Society for Heart and Lung Transplantation: eleventh official pediatric lung and heart/lung transplantation report2008 J Heart Lung Transplant 27 2008 978 983
3. J.D. Christie, J.S. Sager, and S.E. Kimmel Impact of primary graft failure on outcomes following lung transplantation Chest 127 2005 161 165
4. S.A. Daud, R.D. Yusen, and B.F. Meyers Impact of immediate primary lung allograft dysfunction on bronchiolitis obliterans syndrome Am J Respir Crit Care Med 175 2007 507 513
5. A. Meister, and M.E. Anderson Glutathione Annu Rev Biochem 52 1983 711 760
6. A.A. Bradley, and C.F. Nathan Glutathione metabolism as a determinant of therapeutic efficacy: a review Cancer Res 44 1984 4224 4232
7. I. Inci, W. Zhai, S. Arni, S. Hillinger, P. Vogt, and W. Weder N-acetylcysteine attenuates lung ischemia-reperfusion injury after lung transplantation Ann Thorac Surg 84 2007 240 246
8. S.G. Sakka, C.C. Rhl, and U.J. Pfeiffer Assessment of cardiac preload and extravascular lung water by single transpulmonary thermodilution Intensive Care Med 26 2000 180 187
9. K. Nakajima, J.C. Powers, B.M. Ashe, and M. Zimmerman Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site J Biol Chem 254 1979 4027 4032
10. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 2001 402 408
11. M. de Perrot, M. Liu, T.K. Waddell, and S. Keshavjee Ischemia- reperfusion-induced lung injury Am J Respir Crit Care Med 167 2003 490 511
12. A.B. Lentsch, and P.A. Ward Regulation of experimental lung inflammation Respir Physiol 128 2001 17 22
13. S. Ghosh, M.J. May, and E.B. Kopp NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses Annu Rev Immunol 16 1998 225 260
14. F. D'Acquisto, M.J. May, and S. Ghosh Inhibition of nuclear factor kappa B (NF-B): an emerging theme in anti-inflammatory therapies Mol Interv 2 2002 22 35
15. J.J. Haddad, R.E. Olver, and S.C. Land Antioxidant/pro-oxidant equilibrium regulates HIF-1alpha and NF-kappa B redox sensitivity Evidence for inhibition by glutathione oxidation in alveolar epithelial cells J Biol Chem 275 2000 21130 21139
16. T.S. Blackwell, T.R. Blackwell, E.P. Holden, B.W. Christman, and J.W. Christman In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation J Immunol 157 1996 1630 1637
17. A.A. Weinbroum, Y. Kluger, and R.B. Abraham Lung preconditioning with N-Acetyl-L-cysteine prevents reperfusion injury after liver no flow-reflow: a dose-response study Transplantation 71 2001 300 306
18. G.R. Bernard N-Acetylcysteine in experimental and clinical acute lung injury Am J Med 275 1991 54S 59S
19. D. Konukoglu, O. Cetinkale, and R. Bulan Effects of N-acetylcysteine on lung glutathione levels in rats after burn injury Burns 23 1997 541 544
20. A.A. Weinbroum Concomitant administration of mannitol and N-acetylcysteine for prevention of lung reperfusion injury J Trauma 60 2006 1290 1296
21. H. Nakano, K. Boudjema, and E. Alexandre Protective effects of N-acetylcysteine on hypothermic ischemia-reperfusion injury of rat liver Hepatology 22 1995 539 545
22. F.R. Rega, W.A. Wuyts, and B.M. Vanaudenaerde Nebulized N-acetyl cysteine protects the pulmonary graft inside the non-heart-beating donor J Heart Lung Transplant 24 2005 1369 1377
23. K. Kawabata, T. Hagio, and S. Matsuoka The role of neutrophil elastase in acute lung injury Eur J Pharmacol 451 2002 1 10
24. M. Bedard, C.D. McClure, and N.L. Schiller Release of interleukin-8, interleukin-6, and colony-stimulating factors by upper airway epithelial cells; implications for cystic fibrosis Am J Respir Cell Mol Biol 9 1993 455 462
25. K. Modelska, J.F. Pittet, H.G. Folkesson, V. Courtney Broaddus, and M.A. Matthay Acid-induced lung injury Protective effect of anti-interleukin-8 pretreatment on alveolar epithelial barrier function in rabbits Am J Respir Crit Care Med 160 1999 1450 1456
26. A.J. Fisher, S.C. Donnelly, and N. Hirani Elevated levels of interleukin-8 in donor lungs is associated with early graft failure after lung transplantation Am J Respir Crit Care Med 163 2001 259 265
27. S. Chollet-Martin, P. Montravers, and C. Gibert High levels of Interleukin-8 in the blood and alveolar spaces of patients with pneumonia and adult respiratory distress syndrome Infect Immun 61 1993 4553 4559
28. J.P. Lynch 3rd, T.J. Standiford, M.W. Rolfe, S.L. Kunkel, and R.M. Strieter Neutrophilic alveolitis in idiopathic pulmonary fibrosis: the role of interleukin-8 Am Rev Respir Dis 145 1992 1433 1439
29. K.H. Lee, P. Rico, T.R. Biliar, and M.R. Pinsky Nitric oxide production after acute, unilateral hydrochloride acid-induced lung injury in a canine model Crit Care Med 26 1998 2042 2047
30. I. Inci, D. Inci, A. Dutly, A. Boehler, and W. Weder Melatonin attenuates posttransplant lung ischemia-reperfusion injury Ann Thorac Surg 73 2002 220 225
31. I. Inci, S. Arni, and D. Inci Impact of topical cooling solution and prediction of pulmonary graft viability from non-heart-beating donors J Heart Lung Transplant 27 2008 1016 1022
32. I. Cetin, U. Ozelik, A. Gomen, N. Kiper, D. Doru, and E. Yalin BALF nitrite as an indicator of inflammation in children with cystic fibrosis Respiration 71 2004 625 629
33. N. Geudens, C. Van De Wauwer, and A.P. Neyrinck N-acetyl cysteine pre-treatment attenuates inflammatory changes in the warm ischemic murine lung J Heart Lung Transplant 26 2007 1326 1332
34. N. Geudens, W.A. Wuyts, and F.R. Rega N-acetyl cysteine attenuates the inflammatory response in warm ischemic pig lungs J Surg Res 146 2008 177 183
35. T.P. Chamogeorgakis, G.G. Kostopanagiotou, and C.A. Kalimeris Effect of N-acetyl-L-cysteine on lung ischaemia reperfusion injury in a porcine experimental model ANZ J Surg 78 2008 72 77
36. I. El-Hamamsy, L.M. Stevens, and M. Carrier Effect of intravenous N-acetylcysteine on outcomes after coronary artery bypass surgery: a randomized, double-blind, placebo-controlled clinical trial J Thorac Cardiovasc Surg 133 2007 7 12
37. A. Prabhu, D.I. Sujatha, N. Kanagarajan, M.A. Vijayalakshmi, and B. Ninan Effect of N-acetylcysteine in attenuating ischemic reperfusion injury in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass Ann Vasc Surg 23 2009 645 651
38. J.D. Christie, M. Carby, R. Bag, P. Corris, M. Hertz, D. Weill ISHLT Working Group on Primary Lung Graft Dysfunction Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part II: definition. A consensus statement of the International Society for Heart and Lung Transplantation J Heart Lung Transplant 24 2005 1454 1459