N-Acetyl Cysteine Pre-treatment Attenuates Inflammatory Changes in the Warm Ischemic Murine Lung

Journal of Heart and Lung Transplantation

Volumn 26, Issue 12, 2007, Pages 1326-1332

  Geudens, Nele ^a   Van De Wauwer, Caroline ^a   Neyrinck, Arne P ^a   Timmermans, Lien ^a   Vanhooren, Hadewijch M ^a   Vanaudenaerde, Bart M ^a   Verleden, Geert M ^a   Verbeken, Erik ^a   Lerut, Toni ^a   Van Raemdonck, Dirk E M ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN; SODIUM CHLORIDE;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG INSTILLATION; FEMALE; INFLAMMATION; ISCHEMIA; KERATINOCYTE; LUNG LAVAGE; LUNG TRANSPLANTATION; LYMPHOCYTE COUNT; MACROPHAGE; MOUSE; NEUTROPHIL COUNT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; REPERFUSION INJURY;

ACETYLCYSTEINE; ANIMALS; BIOPSY; BRONCHOALVEOLAR LAVAGE; CELL COUNT; CHEMOKINES; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; FREE RADICAL SCAVENGERS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKOCYTES; LUNG; LUNG TRANSPLANTATION; LYMPHOCYTES; MACROPHAGES; MICE; REPERFUSION INJURY; WARM ISCHEMIA;

EID: 37149041409     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.healun.2007.09.008     Document Type: Article

References (27)

1. Egan T.M., Lambert Jr. C.J., Reddick R., et al. A strategy to increase the donor pool: use of cadaver lungs for transplantation. Ann Thorac Surg 52 (1991) 1113-1120
2. Alessandrini F., D'Armini A.M., Roberts C.S., Reddick R.L., and Egan T.M. When does the lung die? II. Ultrastructural evidence of pulmonary viability after "death.". J Heart Lung Transplant 13 (1994) 748-757
3. D'Armini A.M., Tom E.J., Roberts C.S., et al. When does the lung die?. Time course of high energy phosphate depletion and relationship to lung viability after "death.". J Surg Res 59 (1995) 468-474
4. Bishop M.J., Boatman E.S., Ivey T.D., Jordan J.P., and Cheney F.W. Reperfusion of ischemic dog lung results in fever, leukopenia, and lung edema. Am Rev Respir Dis 134 (1986) 752-756
5. Christie J.D., Sager J.S., Kimmel S.E., et al. Impact of primary graft failure on outcomes following lung transplantation. Chest 127 (2005) 161-165
6. Allison R.C., Kyle J., Adkins W.K., et al. Effect of ischemia reperfusion or hypoxia reoxygenation on lung vascular permeability and resistance. J Appl Physiol 69 (1990) 597-603
7. Barie P.S., Hakim T.S., and Malik A.B. Effect of pulmonary artery occlusion and reperfusion on extravascular fluid accumulation. J Appl Physiol 50 (1981) 102-106
8. Geudens N., Vanaudenaerde B.M., Neyrinck A.P., et al. Impact of warm ischemia on different leukocytes in bronchoalveolar lavage from mouse lung: possible new targets to condition the pulmonary graft from the non-heart-beating donor. J Heart Lung Transplant 25 (2006) 839-846
9. Schreck R., Rieber P., and Baeuerle P.A. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J 10 (1991) 2247-2258
10. Wuyts W.A., Vanaudenaerde B.M., Dupont L.J., Demedts M.G., and Verleden G.M. N-acetylcysteine reduces chemokine release via inhibition of p38 MAPK in human airway smooth muscle cells. Eur Respir J 22 (2003) 43-49
11. Wuyts W.A., Vanaudenaerde B.M., Dupont L.J., et al. N-acetylcysteine inhibits interleukin-17-induced interleukin-8 production from human airway smooth muscle cells: a possible role for anti-oxidative treatment in chronic lung rejection?. J Heart Lung Transplant 23 (2004) 122-127
12. Rega F.R., Wuyts W.A., Vanaudenaerde B.M., et al. Nebulized N-acetyl cysteine protects the pulmonary graft inside the non-heart-beating donor. J Heart Lung Transplant 24 (2005) 1369-1377
13. Van Raemdonck D.E., Jannis N.C., De Leyn P.R., Flameng W.J., and Lerut T.E. Warm ischemic tolerance in collapsed pulmonary grafts is limited to 1 hour. Ann Surg 228 (1998) 788-796
14. Van Raemdonck D.E., Rega F.R., Neyrinck A.P., et al. Non-heart-beating donors. Semin Thorac Cardiovasc Surg 16 (2004) 309-321
15. Demedts M., Behr J., Buhl R., Costabel U., et al. High-dose acetylcysteine in idiopathic pulmonary fibrosis. N Engl J Med 353 (2005) 2229-2242
16. Decramer M., Rutten-van Molken M., Dekhuijzen P.N., et al. Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial. Lancet 365 (2005) 1552-1560
17. Olsson B., Johansson M., Gabrielsson J., and Bolme P. Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine. Eur J Clin Pharmacol 34 (1988) 77-82
18. Naidu B.V., Farivar A.S., Woolley S.M., Byrne K., and Mulligan M.S. Chemokine response of pulmonary artery endothelial cells to hypoxia and reoxygenation. J Surg Res 114 (2003) 163-171
19. Naidu B.V., Krishnadasan B., Farivar A.S., et al. Early activation of the alveolar macrophage is critical to the development of lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg 126 (2003) 200-207
20. de Perrot M., Liu M., Waddell T.K., and Keshavjee S. Ischemia-reperfusion-induced lung injury. Am J Respir Crit Care Med 167 (2003) 490-511
21. Molls R.R., Savransky V., Liu M., et al. Keratinocyte-derived chemokine is an early biomarker of ischemic acute kidney injury. Am J Physiol Renal Physiol 290 (2006) F1187-F1193
22. Sekine Y., Yasufuku K., Heidler K.M., et al. Monocyte chemoattractant protein-1 and RANTES are chemotactic for graft infiltrating lymphocytes during acute lung allograft rejection. Am J Respir Cell Mol Biol 23 (2000) 719-726
23. Huffnagle G.B., Strieter R.M., Standiford T.J., et al. The role of monocyte chemotactic protein-1 (MCP-1) in the recruitment of monocytes and CD4+ T cells during a pulmonary Cryptococcus neoformans infection. J Immunol 155 (1995) 4790-4797
24. Lukacs N.W., Strieter R.M., Warmington K., et al. Differential recruitment of leukocyte populations and alteration of airway hyperreactivity by C-C family chemokines in allergic airway inflammation. J Immunol 158 (1997) 4398-4404
25. Krishnadasan B., Naidu B.V., Byrne K., et al. The role of proinflammatory cytokines in lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg 125 (2003) 261-272
26. Schreck R., Albermann K., and Baeuerle P.A. Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Rad Res Commun 17 (1992) 221-237
27. Bell M.D. Non-heart beating organ donation: old procurement strategy-new ethical problems. J Med Ethics 29 (2003) 176-181