Abnormal DNA content in oral epithelial dysplasia is associated with increased risk of progression to carcinoma

British Journal of Cancer

Volumn 103, Issue 9, 2010, Pages 1432-1442

  Bradley, G ^a,b   Odell, E W ^c   Raphael, S ^d   Ho, J ^a   Le, L W ^e   Benchimol, S ^f   Kamel Reid, S ^b,e  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^e UNIVERSITY HEALTH NETWORK   (Canada)

^f YORK UNIVERSITY   (Canada)

Author keywords

carcinoma; DNA cytometry; epithelial dysplasia; oral

Indexed keywords

PROTEIN P53;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER RISK; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA CONTENT; EPITHELIUM CELL; EPITHELIUM DYSPLASIA; FEMALE; HUMAN; HUMAN TISSUE; IMAGE CYTOMETRY; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MOUTH CARCINOMA; MOUTH DISEASE; MOUTH MUCOSA; ORAL EPITHELIAL DYSPLASIA; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA; DISEASE PROGRESSION; DNA, NEOPLASM; FEMALE; HUMANS; IMAGE CYTOMETRY; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MIDDLE AGED; MOUTH MUCOSA; MOUTH NEOPLASMS; PRECANCEROUS CONDITIONS; RISK;

EID: 78049241479     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6605905     Document Type: Article

References (32)

1. Califano J, van der Riet P, Westra W, Nawroz H, Clayman G, Piantadosi S, Corio R, Lee D, Greenberg B, Koch W, Sidransky D (1996) Genetic progression model for head and neck cancer: implications for field cancerization. Cancer Res 56: 2488-2492
2. Cervigne NK, Reis PP, Machado J, Sadikovic B, Bradley G, Galloni NN, Pintilie M, Jurisica I, Perez-Ordonez B, Gilbert R, Gullane P, Irish J, Kamel-Reid S (2009) Identification of a microRNA signature associated with progression of leukoplakia to oral carcinoma. Hum Mol Genet 18: 4818-4829
3. Cruz IB, Snijders PJ, Meijer CJ, Braakhuis BJ, Snow GB, Walboomers JM, van der Waal I (1998) p53 expression above the basal cell layer in oral mucosa is an early event of malignant transformation and has predictive value for developing oral squamous cell carcinoma. J Pathol 184: 360-368
4. Curfman GD, Morrissey S, Drazen JM (2006) Retraction: Sudbo J et al. DNA content as a prognostic marker in patients with oral leukoplakia. N Engl J Med, 2001;344:1270-8
5. Sudbo J et al. The influence of resection and aneuploidy on mortality in oral leukoplakia. N Engl J Med, 2004;350:1405-13.
6. N Engl J Med 355: 1927
7. Diwakar N, Sperandio M, Sherriff M, Brown A, Odell EW (2005) Heterogeneity, histological features and DNA ploidy in oral carcinoma by image-based analysis. Oral Oncol 41: 416-422
8. Doudkine A, Macaulay C, Poulin N, Palcic B (1995) Nuclear texture measurements in image cytometry. Pathologica 87: 286-299
9. Galipeau PC, Cowan DS, Sanchez CA, Barrett MT, Emond MJ, Levine DS, Rabinovitch PS, Reid BJ (1996) 17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus. Proc Natl Acad Sci USA 93: 7081-7084
10. Ganem NJ, Storchova Z, Pellman D (2007) Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev 17: 157-162
11. Guillaud M, Zhang L, Poh C, Rosin MP, MacAulay C (2008) Potential use of quantitative tissue phenotype to predict malignant risk for oral premalignant lesions. Cancer Res 68: 3099-3107
12. Hall GL, Shaw RJ, Field EA, Rogers SN, Sutton DN, Woolgar JA, Lowe D, Liloglou T, Field JK, Risk JM (2008) p16 Promoter methylation is a potential predictor of malignant transformation in oral epithelial dysplasia. Cancer Epidemiol Biomarkers Prev 17: 2174-2179
13. Haroske G, Baak JP, Danielsen H, Giroud F, Gschwendtner A, OberholzerM, Reith A, Spieler P, Bocking A (2001) Fourth updated ESACPconsensus report on diagnostic DNA image cytometry. Anal Cell Pathol23: 89-95
14. Hedley DW (1994) DNA analysis from paraffin-embedded blocks. MethodsCell Biol 41: 231-240
15. Holmstrup P, Vedtofte P, Reibel J, Stoltze K (2006) Long-term treatmentoutcome of oral premalignant lesions. Oral Oncol 42: 461-474
16. Hunter KD, Parkinson EK, Harrison PR (2005) Profiling early head andneck cancer. Nat Rev Cancer 5: 127-135
17. Jordan RC, Macabeo-Ong M, Shiboski CH, Dekker N, Ginzinger DG, Wong DT, Schmidt BL (2004) Overexpression of matrix metalloproteinase-1and-9 mRNA is associated with progression of oral dysplasia to cancer.Clin Cancer Res 10: 6460-6465
18. Klanrit P, Sperandio M, Brown AL, Shirlaw PJ, Challacombe SJ, Morgan PR,Odell EW (2007) DNA ploidy in proliferative verrucous leukoplakia.Oral Oncol 43: 310-316
19. Maley CC, Galipeau PC, Li X, Sanchez CA, Paulson TG, Blount PL, Reid BJ(2004) The combination of genetic instability and clonal expansionpredicts progression to esophageal adenocarcinoma. Cancer Res 64:7629-7633
20. Mao L, Lee JS, Fan YH, Ro JY, Batsakis JG, Lippman S, Hittelman W, Hong WK (1996) Frequent microsatellite alterations at chromosomes 9p21 and3p14 in oral premalignant lesions and their value in cancer riskassessment. Nat Med 2: 682-685
21. Napier SS, Speight PM (2008) Natural history of potentially malignant orallesions and conditions: an overview of the literature. J Oral Pathol Med37: 1-10
22. Olaharski AJ, Sotelo R, Solorza-Luna G, Gonsebatt ME, Guzman P,Mohar A, Eastmond DA (2006) Tetraploidy and chromosomal instabilityare early events during cervical carcinogenesis. Carcinogenesis 27:337-343
23. Partridge M, Pateromichelakis S, Phillips E, Emilion GG, A'Hern RP,Langdon JD (2000) A case-control study confirms that microsatelliteassay can identify patients at risk of developing oral squamous cellcarcinoma within a field of cancerization. Cancer Res 60: 3893-3898
24. Rabinovitch PS, Longton G, Blount PL, Levine DS, Reid BJ (2001) Predictors of progression in Barrett's esophagus III: baseline flow cytometric variables. Am J Gastroenterol 96: 3071-3083
25. Reibel J (2003) Prognosis of oral pre-malignant lesions: significance of clinical, histopathological, and molecular biological characteristics. Crit Rev Oral Biol Med 14: 47-62
26. Rosin MP, Cheng X, Poh C, Lam WL, Huang Y, Lovas J, Berean K, Epstein JB, Priddy R, Le ND, Zhang L (2000) Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia. Clin Cancer Res 6: 357-362
27. Schepman KP, van der Meij EH, Smeele LE, van der Waal I (1998) Malignant transformation of oral leukoplakia: a follow-up study of a hospital-based population of 166 patients with oral leukoplakia from the Netherlands. Oral Oncol 34: 270-275
28. Shin DM, Charuruks N, Lippman SM, Lee JJ, Ro JY, Hong WK, Hittelman WN (2001) p53 protein accumulation and genomic instability in headand neck multistep tumorigenesis. Cancer Epidemiol Biomarkers Prev 10:603-609
29. Storchova Z, Kuffer C (2008) The consequences of tetraploidy andaneuploidy. J Cell Sci 121: 3859-3866
30. Torres-Rendon A, Stewart R, Craig GT, Wells M, Speight PM (2009) DNAploidy analysis by image cytometry helps to identify oral epithelialdysplasias with a high risk of malignant progression. Oral Oncol 45:468-473
31. Warnakulasuriya S, Johnson NW, van der Waal I (2007) Nomenclature andclassification of potentially malignant disorders of the oral mucosa.J Oral Pathol Med 36: 575-580
32. Warnakulasuriya S, Reibel J, Bouquot J, Dabelsteen E (2008) Oralepithelial dysplasia classification systems: predictive value, utility,weaknesses and scope for improvement. J Oral Pathol Med 37:127-133