Catalytic function of PLA2G6 is impaired by mutations associated with infantile neuroaxonal dystrophy but not dystonia-parkinsonism

PLoS ONE

Volumn 5, Issue 9, 2010, Pages

  Engel, Laura A ^a   Jing, Zheng ^a   O'Brien, Daniel E ^a   Sun, Mengyang ^a   Kotzbauer, Paul T ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID DERIVATIVE; LIPID; LYSOPHOSPHOLIPASE; LYSOPHOSPHOLIPID; MUTANT PROTEIN; PHOSPHOLIPASE; PHOSPHOLIPASE A2 GROUP VI; PHOSPHOLIPID; RECOMBINANT ENZYME; PLA2G6 PROTEIN, HUMAN;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DYSTONIA; EMBRYO; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENE MUTATION; HUMAN; HUMAN CELL; HYDROLYSIS; NEUROAXONAL DYSTROPHY; NEURODEGENERATION WITH BRAIN IRON ACCUMULATION; NUCLEOTIDE SEQUENCE; PARKINSONISM; PATHOPHYSIOLOGY; PHENOTYPE; REGULATORY MECHANISM; WILD TYPE; AMINO ACID SEQUENCE; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION;

PARKINSONIA;

AMINO ACID SEQUENCE; CATALYSIS; DYSTONIA; GROUP VI PHOSPHOLIPASES A2; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; NEUROAXONAL DYSTROPHIES; PARKINSONIAN DISORDERS;

EID: 77958612571     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012897     Document Type: Article

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