Identical IGHV-D-J gene rearrangement may precede the clinical onset of chronic lymphocytic leukemia by several years

American Journal of Hematology

Volumn 85, Issue 11, 2010, Pages 868-871

  Frezzato, Maurizio ^a   Giaretta, Ilaria ^a   Madeo, Domenico ^a   Rodeghiero, Francesco ^a  

^a SAN BORTOLO HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; CD20 ANTIGEN; CD22 ANTIGEN; CD23 ANTIGEN; CD38 ANTIGEN; CD5 ANTIGEN; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; GENOMIC DNA; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN J CHAIN; PROTEIN KINASE ZAP 70; RNA;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CANCER DIAGNOSIS; CANCER INCIDENCE; CHROMOSOME 13Q; CHRONIC LYMPHATIC LEUKEMIA; FEMALE; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; GENE DELETION; GENE EXPRESSION; GENE REARRANGEMENT; GENE SEQUENCE; HUMAN; IMMUNOGLOBULIN HEAVY CHAIN GENE; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOPHENOTYPING; LEUKEMOGENESIS; LYMPHOCYTE CLONE; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGE OF ONSET; AGED; B-LYMPHOCYTES; BASE SEQUENCE; CLONE CELLS; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENES, IMMUNOGLOBULIN HEAVY CHAIN; HUMANS; INCIDENCE; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MIDDLE AGED; MUTATION; POLYMERASE CHAIN REACTION; TIME FACTORS;

EID: 77958602015     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.21854     Document Type: Article

References (22)

1. Rawstron A, Green MJ, Kuzmichi A, et al. Monoclonal B lymphocytes with the characteristics of "indolent" chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts. Blood 2002; 100: 635-639.
2. Ghia P, Prato G, Scielzo C, et al. Monoclonal CD5+ and CD5- B-lymphocyte expansions are frequent in the peripheral blood of the elderly. Blood 2004; 103: 2337-2342.
3. Marti GE, Rawstron AC, Ghia P, et al. Diagnostic criteria for monoclonal B-cell lymphocytosis. Br J Hematol 2005; 130: 325-332.
4. Landgren O, Albitar M, Ma W, et al. B-cell clones as early markers for chronic lymphocytic leukemia. N Engl J Med 2009; 360: 659-667.
5. Rodeghiero F, Tosetto A. The epidemiology of inherited thrombophilia: The VITA Project. Thromb Haemost 1997; 78: 636-640.
6. Tosetto A, Frezzato M, Rodeghiero F. Prevalence and risk factors of non-fatal venous thromboembolism in the active population of the VITA Project. J Thromb Haemost 2003; 1: 1724-1729.
7. Cheson BD, Bennett JM, Grever M, et al. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: Revised guidelines for diagnosis and treatment. Blood 1996; 87: 4990-4997.
8. Rai KR, Savitsky A, Cronkite EP, et al. Clinical staging of chronic lymphocytic leukemia. Blood 1975; 46: 219-234.
9. van Dongen JJ, Langerak AW, Brüggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 concerted action BMH4-CT98-3936. Leukemia 2003; 17: 2257-2317.
10. Novella E, Giaretta I, Elice F, et al. Fluorescent polymerase chain reaction and capillary electrophoresis for IgH rearrangement and minimal residual disease evaluation in multiple myeloma. Haematologica 2002; 87: 1157-1164.
11. Giudicelli V, Chaume D, Lefranc MP. IMGT/V-QUEST, an integrated software program for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis. Nucleic Acids Res 2004; 32: W435-W440.
12. Fais F, Sellars B, Ghiotto F, et al. Examples of in vivo isotype class switching in IgM+ chronic lymphocytic leukemia B cells. J Clin Invest 1996; 98: 1659-1666.
13. Stelzer GT, Marti G, Hurley A, et al. U.S.-Canadian Consensus recommendations on the immunophenotypic analysis of hematologic neoplasia by flow cytometry: Standardization and validation of laboratory procedures. Cytometry 1997; 30: 214-230.
14. Damle RN, Wasil T, Fais F, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999; 94: 1840-1847.
15. Knapp W, Strobl H, Majdic O. Flow cytometric analysis of cell-surface and intracellular antigens in leukemia diagnosis. Cytometry 1994; 18: 187-198.
16. Crespo M, Bosch F, Villamor N, et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 2003; 348: 1764-1775.
17. Dewald GW, Brockman SR, Paternoster SF, et al. Chromosome anomalies detected by interphase fluorescence in situ hybridization: Correlation with significant biological features of B-cell chronic lymphocytic leukaemia. Br J Haematol 2003; 121: 287-295.
18. Linch DC. Neoplastic lymphoproliferative disorders. In: McGee JOD, Isaccson PG, Wright NA, editors. Oxford Textbook of Pathology, Vol. 2. Oxford, UK: Oxford University Press; 1992. p 1712.
19. Frezzato M, Tosetto A, Giaretta I, Rodeghiero F. The incidence of chronic lymphocytic leukemia. Blood 2004; 104: 768a.
20. Dagklis A, Fazi C, Sala C, et al. The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)-like monoclonal B lymphocytosis is different from CLL: Diagnostic implications for clinical monitoring. Blood 2009; 114: 26-32.
21. H3-21 genes characterize a new subset of chronic lymphocytic leukemia. Blood 2002; 99: 2262-2264.
22. Kay NE, Hamblin TJ, Jelinek DF, et al. Chronic lymphocytic leukemia. Hematol Am Soc Hematol Educ Program 2002: 193-213.