Nephrocystin-1 forms a complex with polycystin-1 via a polyproline Motif/SH3 domain interaction and regulates the apoptotic response in mammals

PLoS ONE

Volumn 5, Issue 9, 2010, Pages

  Wodarczyk, Claas ^a   Distefano, Gianfranco ^a   Rowe, Isaline ^a   Gaetani, Massimiliano ^a   Bricoli, Barbara ^a   Muorah, Mordi ^b,c   Spitaleri, Andrea ^a   Mannella, Valeria ^a   Ricchiuto, Piero ^a   Pema, Monika ^a   Castelli, Maddalena ^a   Casanova, Ariel E ^a   Mollica, Luca ^a   Banzi, Manuela ^a   Boca, Manila ^a   Antignac, Corinne ^b,c   Saunier, Sophie ^b,c   Musco, Giovanna ^a   Boletta, Alessandra ^a  

^a DULBECCO TELETHON INSTITUTE   (Italy)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

NEPHROCYSTIN 1; POLYCYSTIN 1; PROLINE; PROTEIN SH3; REGULATOR PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; MEMBRANE PROTEIN; NPHP1 PROTEIN, HUMAN; NPHP1 PROTEIN, MOUSE; PEPTIDE; POLYCYSTIC KIDNEY DISEASE 1 PROTEIN; POLYCYSTIN; POLYPROLINE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BINDING KINETICS; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; COMPLEX FORMATION; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; KIDNEY POLYCYSTIC DISEASE; MAMMAL CELL; MOUSE; NEPHRONOPHTHISIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROLINE RICH PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CELL LINE; CHEMISTRY; DOG; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE MUTANT; PATHOPHYSIOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; SRC HOMOLOGY DOMAIN;

MAMMALIA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CARRIER PROTEINS; CELL LINE; DOGS; HUMANS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PEPTIDES; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SRC HOMOLOGY DOMAINS; TRPP CATION CHANNELS;

EID: 77958565531     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012719     Document Type: Article

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