NF-κB inhibitors from Brucea javanica exhibiting intracellular effects on reactive oxygen species

Anticancer Research

Volumn 30, Issue 9, 2010, Pages 3295-3300

  Kim, Jeong Ah ^a   Lau, Edward K ^a   Pan, Li ^a   Carcache De Blanco, Esperanza J ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Brucea javanica; Cytotoxicity; Mitochondria; NF B; NFAT; ROS

Indexed keywords

BRUCEA JAVANICA EXTRACT; BRUCEAJAVANONE B; BRUCEANTIN; BRUCEINE D; CHRYSOERIOL; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NUCLEAR FACTOR; REACTIVE OXYGEN METABOLITE; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG; BRUCEAJAVANIN B; BRUCEINE A; FLAVONOID; FLAVONOLIGNAN; HYDNOCARPIN; PLANT EXTRACT; QUASSINOID DERIVATIVE; TRANSCRIPTION FACTOR NFAT; TRITERPENE;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRION; PRIORITY JOURNAL; UPREGULATION; BRUCEA; CHEMISTRY; DRUG ANTAGONISM; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; TUMOR CELL LINE;

BRUCEA; CELL LINE, TUMOR; FLAVONOIDS; FLAVONOLIGNANS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; PLANT EXTRACTS; QUASSINS; REACTIVE OXYGEN SPECIES; TRITERPENES;

EID: 77958560249     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Kim IH, Takashima S, Hitotsuyanagi Y, Hasuda T and Takeya K: New quassinoids, javanicolides C and D and javanicosides B-F, from seeds of Brucea javanica. J Nat Prod 67(5): 863-868, 2004. (Pubitemid 38702746)
2. Pan L, Chin Y-W, Chai H-B, Ninh TN, Soejarto DD and Kinghorn AD: Bioactivity-guided isolation of cytotoxic constituents of Brucea javanica collected in Vietnam. Bioorg Med Chem 17(6): 2219-2224, 2009.
3. Su B-N, Chang LC, Park EJ, Cuendet M, Santarisiero BD, Mesecar AD, Mehta RG, Fong HH, Pezzuto JM and Kinghorn AD: Bioactive constituents of the seeds of Brucea javanica. Planta Medica 68(8): 730-733, 2002.
4. Okamoto T, Sanda T and Asamitsu K: NF-κB signaling and carcinogenesis. Curr Pharm Design 13(5): 447-462, 2007.
5. Seo E-K, Wani MC, Wall ME, Navarro H, Mukherjee R, Farnsworth NR and Kinghorn AD: New bioactive aromatic compounds from Vismia guianensis. Phytochemistry 55(1): 35-42, 2000.
6. Ding GJF, Fischer PA, Boltz RC, Schmidt JA, Colaianne JJ, Gough A, Rubin RA and Miller DK: Characterization and quantitation of NF-κB nuclear translocation induced by interleukin-1 and tumor necrosis factor-α. J Biol Chem 273(44): 28897-28905, 1998.
7. Ge Y, Montano I, Rustici G, Freebern WJ, Haggerty CM, Cui W, Ponciano-Jackson D, Chandramouli GVR, Gardner ER, Figg WD, Abu-Asab M, Tsokos M, Jackson SH and Gardner K: Selective leukemic-cell killing by a novel functional class of thalidomide analogs. Blood 108(13): 4126-4135, 2006.
8. Masuda ES, Imamura R, Amasaki Y, Arai K and Arai N: Signalling into the T-cell nucleus NFAT regulation. Cell Signal 10(9): 599-611, 1998. (Pubitemid 28448460)
9. Renard P, Ernest I, Houbion A, Art M, Le Calvez H, Raes M and Remade J: Development of a sensitive multi-well colorimetric assay for active NF-κB. Nucleic Acids Res 29(4): e21-e21, 2001.
10. Salim AA, Pawlus AD, Chai H-B, Farnsworth NR, Kinghorn AD and Carcache-Blanco EJ: Ponapensin, a cyclopenta[bc] benzopyran with potent NF-κB inhibitory activity from Aglaia ponapensis. Bioorg Med Chem Lett 17(1): 109-112, 2007.
11. Park Y, Moon B-H, Yang H, Lee Y, Lee E and Lim Y: Complete assignments of NMR data of 13 hydroxymethoxyflavones. Magn Reson Chem 45(12): 1072-1075, 2007.
12. Yen G-C, Chiang H-C, Wu C-H and Yeh C-T: The protective effects of Aspergillus Candida metabolites against hydrogen peroxide-induced oxidative damage to Int 407 cells. Food Chem Toxicol 41(11): 1561-1567, 2003.
13. Carcache de Blanco EJ, Pandit B, Hu Z, Shi J, Lewis A and Li P-K: Inhibitors of NF-κB derived from thalidomide. Bioorg Med Chem Lett 17(21): 6031-6035, 2007.
14. Salvioli S, Ardizzoni A, Franceschi C and Cossarizza A: JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess ΔΨ changes in intact cells: implications for studies on mitochondrial functionality during apoptosis. FEBS Lett 411(1): 77-82, 2007.
15. Le Bras M, Clement MV, Pervaiz S and Brenner C: Reactive oxygen species and the mitochondrial signaling pathway of cell death. Histol Histopathol 20(1): 205-219, 2005.
16. Pelicano H, Carney D and Huang P: ROS stress in cancer cells and therapeutic implications. Drug Res Upd 7(2): 97-110, 2004. (Pubitemid 38736063)
17. Cuendet M and Pezzuto JM: Antitumor activity of bruceantin: An old drug with new promise. J Nat Prod 67(2): 269-272, 2004.
18. Lidert Z, Wing K, Polonsky J, Imakura Y, Okano M, Tani S, Lin Y-M, Kiyokawa H and Lee K-H: Insect antifeedant and growth inhibitory activity of forty-six quassinoids on two species of agricultural pests. J Nat Prod 50(3): 442-448, 1987.
19. Zhou Y, Hileman EO, Plunkett W, Keating MJ and Huang P: Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents. Blood 101(10): 4098-4104, 2003.
20. Choi C-W, Jung HA, Rang SS and Choi JS: Antioxidant constituents and a new triterpenoid glycoside from Flos Lonicerae. Arch Pharm Res 30(1): 1-7, 2007.
21. Pettit RG, Meng Y, Stevenson AC, Doubek LD, Knight CJ, Cichacz Z, Pettit KR, Chapuis J-C and Schmidt MJ: Isolation and structure of palstatin from the Amazon tree Hymenea palustris. J Nat Prod 66(2): 259-262, 2003.
22. Zhang J and Kong L: Study on chemical constituents from Artemisia selengensis leaves. Zhongguo Yaoxue Zazhi (Beijing, China) 40(23): 1778-1780, 2005. (Pubitemid 43219627)