EGR-2 is not required for in vivo CD4 T cell mediated immune responses

PLoS ONE

Volumn 5, Issue 9, 2010, Pages

  Ramón, Hilda E ^a   Cejas, Pedro J ^a   laRosa, David ^a   Rahman, Adeeb ^a   Harris, John E ^a   Zhang, Jidong ^a   Hunter, Christopher ^b   Choi, Yongwon ^a   Turka, Laurence A ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA SCHOOL OF VETERINARY MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CD4 ANTIGEN; CYTOKINE; EARLY GROWTH RESPONSE FACTOR 2; HERMES ANTIGEN; L SELECTIN; MINOR HISTOCOMPATIBILITY ANTIGEN; EGR2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RESPONSE; FEMALE; IMMUNOREGULATION; IN VIVO CULTURE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MOUSE; NONHUMAN; PHENOTYPE; TOXOPLASMA GONDII; ANIMAL; GENETICS; HUMAN; IMMUNOLOGY; LYMPHOCYTIC CHORIOMENINGITIS; MOUSE MUTANT; PARASITOLOGY; PHYSIOLOGY; TOXOPLASMA; TOXOPLASMOSIS; VIROLOGY;

LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MUS; TOXOPLASMA GONDII;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; EARLY GROWTH RESPONSE PROTEIN 2; FEMALE; HUMANS; IMMUNITY, CELLULAR; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MICE; MICE, KNOCKOUT; TOXOPLASMA; TOXOPLASMOSIS;

EID: 77958550103     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012904     Document Type: Article

References (20)

1. O'Donovan KJ, Tourtellotte WG, Millbrandt J, Baraban JM (1999) The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience. Trends Neurosci 22(4): 167-73.
2. Yang SZ, Eltoum IA, Abdulkadir SA (2006) Enhanced EGR1 activity promotes the growth of prostate cancer cells in an androgen-depleted environment. J Cell Biochem 97(6): 1292-9.
3. Laslo P, Spooner CJ, Warmflash A, Lancki DW, Lee HJ, et al. (2006) Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell 126(4): 755-66.
4. Gamper CJ, Powell JD (2010) Genetic and biochemical regulation of CD4 T cell effector differentiation: insights from examination of T cell clonal anergy. Immunol Res, On-line publication.
5. Skerka C, Decker EL, Zipfel PF (1997) Coordinate expression and distinct DNAbinding characteristics of the four EGR-zinc finger proteins in Jurkat T lymphocytes. Immunobiology 198(1-3): 179-91.
6. Collins S, Lutz MA, Zarek PE, Anders RA, Kersh GJ, et al. (2008) Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3. Eur J Immunol 38(2): 528-36.
7. Decker EL, Nehmann N, Kampen E, Eibel H, Zipfel PF, et al. (2003) Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression. Nucleic Acids Res 31(3): 911-21.
8. Cron RQ, Bandyopadhyay R, Genin A, Brunner M, Kersh GJ, et al. (2006) Early growth response-1 is required for CD154 transcription. J Immunol 176(2): 811-8.
9. Gómez-Martín D, Díaz-Zamudio M, Galindo-Campos M, Alcocer-Varela J (2009) Early growth response transcription factors and the modulation of immune response Implications towards autoimmunity. Autoimmun Rev 9(6): 454-458.
10. Harris JE, Bishop KD, Phillips NE, Mordes JP, Greiner DL (2004) Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells. J Immunol 173(12): 7331-8.
11. Safford M, Collins S, Lutz MA, Allen A, Huang CT (2005) Egr-2 and Egr-3 are negative regulators of T cell activation. Nat Immunol 6(5): 472-80.
12. Zhu B, Symonds AL, Martin JE, Kioussis D, Wraith DC (2008) Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease. J Exp Med 205(10): 2295-307.
13. Mittelstadt PR, Ashwell JD (1998) Cyclosporin A-sensitive transcription factor Egr-3 regulates Fas ligand expression. Mol Cell Biol 18(7): 3744-51.
14. Mittelstadt PR, Ashwell JD (1999) Role of Egr-2 in up-regulation of Fas ligand in normal T cells and aberrant double-negative lpr and gld T cells. J Biol Chem 274(5): 3222-7.
15. Topilko P, Schneider-Maunoury S, Levi G, Baron-Van Evercooren A, Chennoufi AB (1994) Krox-20 controls myelination in the peripheral nervous system. Nature 371(6500): 796-9.
16. Dzierszinski FS, Hunter CA (2008) Advances in the use of genetically engineered parasites to study immunity to Toxoplasma gondii. Parasite Immunol 30(4): 235-44.
17. Denkers EY, Gazzinelli RT (1998) Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection. Clin Microbiol 11(4): 569-88.
18. Khanolkar A, Fuller MJ, Zajac AJ (2002) T cell responses to viral infections: lessons from lymphocytic choriomeningitis virus. Immunol Res 26(1-3): 309-21.
19. Taillebourg E, Buart S, Charnay P (2002) Conditional, floxed allele of the Krox20 gene. Genesis 32: 112-113.
20. Gelman AE, Zhang J, Choi Y, Turka LA (2004) Toll-like receptor ligands directly promote activated CD4+ T cell survival. J Immunol 172(10): 6065-73.