Fungalysin and dipeptidyl-peptidase gene transcription in Microsporum canis strains isolated from symptomatic and asymptomatic cats

Veterinary Microbiology

Volumn 146, Issue 1-2, 2010, Pages 179-182

  Mathy, Anne ^a   Baldo, Aline ^a   Schoofs, Laura ^a   Cambier, Ludivine ^a   Defaweux, Valérie ^a   Tabart, Jérémy ^a   Maréchal, Françoise ^a   Symoens, Françoise ^b   Mignon, Bernard ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b SCIENTIFIC INSTITUTE OF PUBLIC HEALTH   (Belgium)

Author keywords

Dermatophytes; Feline ringworm; Secreted proteases; Strain differentiation

Indexed keywords

DIPEPTIDYL PEPTIDASE; FUNGALYSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIUM ADHERENCE; CAT; DERMATOPHYTOSIS; EPIDERMIS; GENETIC TRANSCRIPTION; MICROSPORUM CANIS; MICROSPORUM CANIS INFECTION; NONHUMAN;

ANIMALS; ASYMPTOMATIC INFECTIONS; CAT DISEASES; CATS; DERMATOMYCOSES; DIPEPTIDYL-PEPTIDASES AND TRIPEPTIDYL-PEPTIDASES; FEMALE; FUNGAL PROTEINS; MALE; MICROSPORUM; PEPTIDE HYDROLASES; TRANSCRIPTION, GENETIC;

ARTHRODERMATACEAE; FELIDAE; FUNGI; MICROSPORUM CANIS;

EID: 77958541493     PISSN: 03781135     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetmic.2010.04.019     Document Type: Article

References (31)

1. Abdel-Rahman S.M., Simon S., Wright K.J., Ndjountche L., Gaedigk A. Tracking Trichophyton tonsurans through a large urban child care center: defining infection prevalence and transmission patterns by molecular strain typing. Pediatrics 2006, 118:2365-2373.
2. Angiolella L., Stringaro A.R., De Bernardis F., Posteraro B., Bonito M., Toccacieli L., Torosantucci A., Colone C., Sanguinetti M., Cassone A., Palamara A.T. Increase of virulence and its phenotypic traits in drug-resistant strains of Candida albicans. Antimicrob. Agents Chemother. 2008, 52:927-936.
3. Baldo A., Tabart J., Vermout S., Mathy A., Collard A., Losson B., Mignon B. Secreted subtilisins of Microsporum canis are involved in adherence of arthroconidia to feline corneocytes. J. Med. Microbiol. 2008, 57:1152-1156.
4. Baldo A., Mathy A., Tabart J., Camponova P., Vermout S., Massart L., Maréchal F., Galleni M., Mignon B. Secreted subtilisin Sub3 from Microsporum canis is required for adherence to but not for invasion of the epidermis. Br. J. Dermatol. 2010, 162:990-997.
5. Bastos I.M., Grellier P., Martins N.F., Cadavid-Restrepo G., de Souza-Ault M.R., Augustyns K., Teixeira A.R., Schrével J., Maigret B., da Silveira J.F., Santana J.M. Molecular, functional and structural properties of the prolyl oligopeptidase of Trypanosoma cruzi (POP Tc80), which is required for parasite entry into mammalian cells. Biochem. J. 2005, 388:29-38.
6. Beauvais A., Monod M., Wyniger J., Debeaupuis J.P., Grouzmann E., Brakch N., Svab J., Hovanessian A.G., Latgé J.P. Dipeptidyl-peptidase IV secreted by Aspergillus fumigatus, a fungus pathogenic to humans. Infect. Immun. 1997, 65:3042-3047.
7. Bergson C.L., Fernandes N.C. Tinea capitis: study of asymptomatic carriers and sick adolescents, adults and elderly who live with children with the disease. Rev. Inst. Med. Trop. Sao Paulo 2001, 43:87-91.
8. Brouta F., Descamps F., Fett T., Losson B., Gerday C., Mignon B. Purification and characterization of a 43.5kDa keratinolytic metalloprotease from Microsporum canis. Med. Mycol. 2001, 39:269-275.
9. Brouta F., Descamps F., Monod M., Vermout S., Losson B., Mignon B. Secreted metalloprotease gene family of Microsporum canis. Infect. Immun. 2002, 70:5676-5683.
10. Descamps F., Brouta F., Monod M., Zaugg C., Baar D., Losson B., Mignon B. Isolation of a Microsporum canis gene family encoding three subtilisin-like proteases expressed in vivo. J. Invest. Dermatol. 2002, 119:830-835.
11. Descamps F.F., Brouta F., Vermout S.M., Willame C., Losson B.J., Mignon B.R. A recombinant 31.5kDa keratinase and a crude exo-antigen from Microsporum canis fail to protect against a homologous experimental infection in guinea pigs. Vet. Dermatol. 2003, 14:305-312.
12. Duek L., Kaufman G., Ulman Y., Berdicevsky I. The pathogenesis of dermatophyte infections in human skin sections. J. Infect. 2004, 48:175-180.
13. Ge J., Feng Y., Ji H., Zhang H., Zheng F., Wang C., Yin Z., Pan X., Tang J. Inactivation of dipeptidyl peptidase IV attenuates the virulence of Streptococcus suis serotype 2 that causes streptococcal toxic shock syndrome. Curr. Microbiol. 2009, 59:248-255.
14. Grellier P., Vendeville S., Joyeau R., Bastos I.M., Drobecq H., Frappier F., Teixeira A.R., Schrével J., Davioud-Charvet E., Sergheraert C., Santana J.M. Trypanosoma cruzi prolyl oligopeptidase Tc80 is involved in nonphagocytic mammalian cell invasion by trypomastigotes. J. Biol. Chem. 2001, 276:47078-47086.
15. Kumagai Y., Konishi K., Gomi T., Yagishita H., Yajima A., Yoshikawa M. Enzymatic properties of dipeptidyl aminopeptidase IV produced by the periodontal pathogen Porphyromonas gingivalis and its participation in virulence. Infect. Immun. 2000, 68:716-724.
16. Kumagai Y., Yajima A., Konishi K. Peptidase activity of dipeptidyl aminopeptidase IV produced by Porphyromonas gingivalis is important but not sufficient for virulence. Microbiol. Immunol. 2003, 47:735-743.
17. Kumagai Y., Yagishita H., Yajima A., Okamoto T., Konishi K. Molecular mechanism for connective tissue destruction by dipeptidyl aminopeptidase IV produced by the periodontal pathogen Porphyromonas gingivalis. Infect. Immun. 2005, 73:2655-2664.
18. Mignon B.R., Losson B.J. Prevalence and characterization of Microsporum canis carriage in cats. J. Med. Vet. Mycol. 1997, 35:249-256.
19. Mignon B.R., Nikkels A.F., Piérard G.E., Losson B.J. The in vitro and in vivo production of a 31.5-kD keratinolytic subtilase from Microsporum canis and the clinical status in naturally infected cats. Dermatology 1998, 196:438-441.
20. Monod M. Secreted proteases from dermatophytes. Mycopathologia 2008, 166:285-294.
21. Okeke C.N., Tsuboi R., Kawai M., Hiruma M., Ogawa H. Isolation of an intron-containing partial sequence of the gene encoding dermatophyte actin (ACT) and detection of a fragment of the transcript by reverse transcription-nested PCR as a means of assessing the viability of dermatophytes in skin scales. J. Clin. Microbiol. 2001, 39:101-106.
22. Rementeria A., López-Molina N., Ludwig A., Vivanco A.B., Bikandi J., Pontón J., Garaizar J. Genes and molecules involved in Aspergillus fumigatus virulence. Rev. Iberoam. Micol. 2005, 22:1-23.
23. Romano C., Valenti L., Barbara R. Dermatophytes isolated from asymptomatic stray cats. Mycoses 1997, 40:471-472.
24. Santana J.M., Grellier P., Schrével J., Teixeira A.R. A Trypanosoma cruzi-secreted 80kDa proteinase with specificity for human collagen types I and IV. Biochem. J. 1997, 325:129-137.
25. Scott D.W., Miller W.H., Griffin C.E. Fungal skin diseases. Small Animal Dermatology 2001, 339-361. Saunders, Philadelphia, WB. G.H. Miller, R.W. Kirk (Eds.).
26. Tabart J., Baldo A., Vermout S., Nusgens B., Lapiere C., Losson B., Mignon B. Reconstructed interfollicular feline epidermis as a model for Microsporum canis dermatophytosis. J. Med. Microbiol. 2007, 56:971-975.
27. Vermout S., Baldo A., Tabart J., Losson B., Mignon B. Secreted dipeptidyl peptidases as potential virulence factors for Microsporum canis. FEMS Immunol. Med. Microbiol. 2008, 54:299-308.
28. Vermout S., Tabart J., Baldo A., Mathy A., Losson B., Mignon B. Pathogenesis of dermatophytosis. Mycopathologia 2008, 166:267-275.
29. Viani F.C., Cazares Viani P.R., Gutierrez Rivera I.N., Gonçalves da Silva E., Rodrigues Paula C., Gambale W. Extracellular proteolytic activity and molecular analysis of Microsporum canis strains isolated from symptomatic and asymptomatic cats. Rev. Iberoam. Micol. 2007, 24:19-23.
30. Yagishita H., Kumagai Y., Konishi K., Takahashi Y., Aoba T., Yoshikawa M. Histopathological studies on virulence of dipeptidyl aminopeptidase IV (DPPIV) of Porphyromonas gingivalis in a mouse abscess model: use of a DPPIV-deficient mutant. Infect. Immun. 2001, 69:7159-7161.
31. Zurita J., Hay R.J. Adherence of dermatophyte microconidia and arthroconidia to human keratinocytes in vitro. J. Invest. Dermatol. 1987, 89:529-534.