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Volumn 5, Issue 9, 2010, Pages

Mutant parkin impairs mitochondrial function and morphology in human fibroblasts

Author keywords

[No Author keywords available]

Indexed keywords

5,5',6,6' TETRACHLORO 1,1',3,3' TETRAETHYLBENZIMIDAZOLYLCARBOCYANINE IODIDE; ADENOSINE TRIPHOSPHATE; CITRATE SYNTHASE; CYTOCHROME C OXIDASE; FLUORESCENT DYE; MUTANT PROTEIN; PARKIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; UBIQUITIN PROTEIN LIGASE;

EID: 77958535699     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012962     Document Type: Article
Times cited : (126)

References (32)
  • 1
    • 0342368772 scopus 로고    scopus 로고
    • Association between early-onset Parkinson's disease and mutations in the parkin gene
    • Lucking CB, Durr A, Bonifati V, Vaughan J, De Michele G, et al. (2000) Association between early-onset Parkinson's disease and mutations in the parkin gene. N Engl J Med 342: 1560-1567.
    • (2000) N Engl J Med , vol.342 , pp. 1560-1567
    • Lucking, C.B.1    Durr, A.2    Bonifati, V.3    Vaughan, J.4    De Michele, G.5
  • 2
    • 67649383293 scopus 로고    scopus 로고
    • Identification of a novel Zn2+-binding domain in the autosomal recessive juvenile Parkinson-related E3 ligase parkin
    • Hristova VA, Beasley SA, Rylett RJ, Shaw GS (2009) Identification of a novel Zn2+-binding domain in the autosomal recessive juvenile Parkinson-related E3 ligase parkin. J Biol Chem 284: 14978-14986.
    • (2009) J Biol Chem , vol.284 , pp. 14978-14986
    • Hristova, V.A.1    Beasley, S.A.2    Rylett, R.J.3    Shaw, G.S.4
  • 3
    • 33847688139 scopus 로고    scopus 로고
    • Structure of the Parkin in-betweenring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson's disease
    • Beasley SA, Hristova VA, Shaw GS (2007) Structure of the Parkin in-betweenring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson's disease. Proc Natl Acad Sci U S A 104: 3095-3100.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 3095-3100
    • Beasley, S.A.1    Hristova, V.A.2    Shaw, G.S.3
  • 4
    • 33751267701 scopus 로고    scopus 로고
    • Parkin: A multifaceted ubiquitin ligase
    • Moore DJ (2006) Parkin: a multifaceted ubiquitin ligase. Biochem Soc Trans 34: 749-753.
    • (2006) Biochem Soc Trans , vol.34 , pp. 749-753
    • Moore, D.J.1
  • 5
    • 2442481789 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative damage in parkin-deficient mice
    • Palacino JJ, Sagi D, Goldberg MS, Krauss S, Motz C, et al. (2004) Mitochondrial dysfunction and oxidative damage in parkin-deficient mice. J Biol Chem 279: 18614-18622.
    • (2004) J Biol Chem , vol.279 , pp. 18614-18622
    • Palacino, J.J.1    Sagi, D.2    Goldberg, M.S.3    Krauss, S.4    Motz, C.5
  • 6
    • 13844313915 scopus 로고    scopus 로고
    • Parkin-deficient mice are not a robust model of parkinsonism
    • Perez FA, Palmiter RD (2005) Parkin-deficient mice are not a robust model of parkinsonism. Proc Natl Acad Sci U S A 102: 2174-2179.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 2174-2179
    • Perez, F.A.1    Palmiter, R.D.2
  • 7
    • 10744221310 scopus 로고    scopus 로고
    • Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse
    • Itier JM, Ibanez P, Mena MA, Abbas N, Cohen-Salmon C, et al. (2003) Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse. Hum Mol Genet 12: 2277-2291.
    • (2003) Hum Mol Genet , vol.12 , pp. 2277-2291
    • Itier, J.M.1    Ibanez, P.2    Mena, M.A.3    Abbas, N.4    Cohen-Salmon, C.5
  • 8
    • 0141891953 scopus 로고    scopus 로고
    • Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons
    • Goldberg MS, Fleming SM, Palacino JJ, Cepeda C, Lam HA, et al. (2003) Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J Biol Chem 278: 43628-43635.
    • (2003) J Biol Chem , vol.278 , pp. 43628-43635
    • Goldberg, M.S.1    Fleming, S.M.2    Palacino, J.J.3    Cepeda, C.4    Lam, H.A.5
  • 9
    • 67649413521 scopus 로고    scopus 로고
    • Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio)
    • Flinn L, Mortiboys H, Volkmann K, Koster RW, Ingham PW, et al. (2009) Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio). Brain 132: 1613-1623.
    • (2009) Brain , vol.132 , pp. 1613-1623
    • Flinn, L.1    Mortiboys, H.2    Volkmann, K.3    Koster, R.W.4    Ingham, P.W.5
  • 10
    • 4544326057 scopus 로고    scopus 로고
    • Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations
    • Muftuoglu M, Elibol B, Dalmizrak O, Ercan A, Kulaksiz G, et al. (2004) Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations. Mov Disord 19: 544-548.
    • (2004) Mov Disord , vol.19 , pp. 544-548
    • Muftuoglu, M.1    Elibol, B.2    Dalmizrak, O.3    Ercan, A.4    Kulaksiz, G.5
  • 11
    • 57749100375 scopus 로고    scopus 로고
    • Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts
    • Mortiboys H, Thomas KJ, Koopman WJ, Klaffke S, Abou-Sleiman P, et al. (2008) Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts. Ann Neurol 64: 555-565.
    • (2008) Ann Neurol , vol.64 , pp. 555-565
    • Mortiboys, H.1    Thomas, K.J.2    Koopman, W.J.3    Klaffke, S.4    Abou-Sleiman, P.5
  • 12
    • 0037386532 scopus 로고    scopus 로고
    • Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
    • Greene JC, Whitworth AJ, Kuo I, Andrews LA, Feany MB, et al. (2003) Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc Natl Acad Sci U S A 100: 4078-4083.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4078-4083
    • Greene, J.C.1    Whitworth, A.J.2    Kuo, I.3    Andrews, L.A.4    Feany, M.B.5
  • 13
    • 2542560342 scopus 로고    scopus 로고
    • Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress
    • Pesah Y, Pham T, Burgess H, Middlebrooks B, Verstreken P, et al. (2004) Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress. Development 131: 2183-2194.
    • (2004) Development , vol.131 , pp. 2183-2194
    • Pesah, Y.1    Pham, T.2    Burgess, H.3    Middlebrooks, B.4    Verstreken, P.5
  • 14
    • 58149314211 scopus 로고    scopus 로고
    • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    • Narendra D, Tanaka A, Suen DF, Youle RJ (2008) Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 183: 795-803.
    • (2008) J Cell Biol , vol.183 , pp. 795-803
    • Narendra, D.1    Tanaka, A.2    Suen, D.F.3    Youle, R.J.4
  • 15
    • 75749156257 scopus 로고    scopus 로고
    • PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
    • Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, et al. (2010) PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin. PLoS Biol 8: e1000298.
    • (2010) PLoS Biol , vol.8
    • Narendra, D.P.1    Jin, S.M.2    Tanaka, A.3    Suen, D.F.4    Gautier, C.A.5
  • 16
    • 75949104449 scopus 로고    scopus 로고
    • Mitochondria get a Parkin' ticket
    • Wild P, Dikic I (2010) Mitochondria get a Parkin' ticket. Nat Cell Biol 12: 104-106.
    • (2010) Nat Cell Biol , vol.12 , pp. 104-106
    • Wild, P.1    Dikic, I.2
  • 18
    • 67650243261 scopus 로고    scopus 로고
    • Parkin-induced mitophagy in the pathogenesis of Parkinson disease
    • Narendra D, Tanaka A, Suen DF, Youle RJ (2009) Parkin-induced mitophagy in the pathogenesis of Parkinson disease. Autophagy 5: 706-708.
    • (2009) Autophagy , vol.5 , pp. 706-708
    • Narendra, D.1    Tanaka, A.2    Suen, D.F.3    Youle, R.J.4
  • 19
    • 77951181836 scopus 로고    scopus 로고
    • PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
    • Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, et al. (2010) PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol 189: 211-221.
    • (2010) J Cell Biol , vol.189 , pp. 211-221
    • Matsuda, N.1    Sato, S.2    Shiba, K.3    Okatsu, K.4    Saisho, K.5
  • 20
    • 77955844260 scopus 로고    scopus 로고
    • The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway
    • Poole AC, Thomas RE, Yu S, Vincow ES, Pallanck L (2010) The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway. PLoS One 5: e10054.
    • (2010) PLoS One , vol.5
    • Poole, A.C.1    Thomas, R.E.2    Yu, S.3    Vincow, E.S.4    Pallanck, L.5
  • 21
    • 77950384477 scopus 로고    scopus 로고
    • Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin
    • Ziviani E, Tao RN, Whitworth AJ (2010) Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proc Natl Acad Sci U S A 107: 5018-5023.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 5018-5023
    • Ziviani, E.1    Tao, R.N.2    Whitworth, A.J.3
  • 22
    • 77955437274 scopus 로고    scopus 로고
    • How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?
    • Ziviani E, Whitworth AJ (2010) How could Parkin-mediated ubiquitination of mitofusin promote mitophagy? Autophagy 6.
    • (2010) Autophagy , pp. 6
    • Ziviani, E.1    Whitworth, A.J.2
  • 25
    • 68549136513 scopus 로고    scopus 로고
    • Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology
    • Grünewald A, Gegg ME, Taanman JW, King RH, Kock N, et al. (2009) Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology. Exp Neurol 219: 266-273.
    • (2009) Exp Neurol , vol.219 , pp. 266-273
    • Grünewald, A.1    Gegg, M.E.2    Taanman, J.W.3    King, R.H.4    Kock, N.5
  • 26
    • 0035231383 scopus 로고    scopus 로고
    • Assessing Functional Integrity of Mitochondria in Vitro and in Vivo
    • In: Pon LA, Schon EA, eds., San Diego: Academic Press
    • Esposti MD (2001) Assessing Functional Integrity of Mitochondria in Vitro and in Vivo. In: Pon LA, Schon EA, eds. Mitochondria. San Diego: Academic Press. pp 75-96.
    • (2001) Mitochondria , pp. 75-96
    • Esposti, M.D.1
  • 28
    • 55749090654 scopus 로고    scopus 로고
    • The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
    • Deng H, Dodson MW, Huang H, Guo M (2008) The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc Natl Acad Sci U S A 105: 14503-14508.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 14503-14508
    • Deng, H.1    Dodson, M.W.2    Huang, H.3    Guo, M.4
  • 29
    • 61649088435 scopus 로고    scopus 로고
    • PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death
    • Gandhi S, Wood-Kaczmar A, Yao Z, Plun-Favreau H, Deas E, et al. (2009) PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. Mol Cell 33: 627-638.
    • (2009) Mol Cell , vol.33 , pp. 627-638
    • Gandhi, S.1    Wood-Kaczmar, A.2    Yao, Z.3    Plun-Favreau, H.4    Deas, E.5
  • 31
    • 37049004489 scopus 로고    scopus 로고
    • Mitochondria in the aetiology and pathogenesis of Parkinson's disease
    • Schapira AH (2008) Mitochondria in the aetiology and pathogenesis of Parkinson's disease. Lancet Neurol 7: 97-109.
    • (2008) Lancet Neurol , vol.7 , pp. 97-109
    • Schapira, A.H.1
  • 32
    • 36049038504 scopus 로고    scopus 로고
    • Loss-offunction of human PINK1 results in mitochondrial pathology and can be rescued by parkin
    • Exner N, Treske B, Paquet D, Holmstrom K, Schiesling C, et al. (2007) Loss-offunction of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J Neurosci 27: 12413-12418.
    • (2007) J Neurosci , vol.27 , pp. 12413-12418
    • Exner, N.1    Treske, B.2    Paquet, D.3    Holmstrom, K.4    Schiesling, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.