Use of a mucoadhesive disk for relief of dry mouth A randomized, double-masked, controlled crossover study

Journal of the American Dental Association

Volumn 141, Issue 10, 2010, Pages 1250-1256

  Ross Kerr, A ^a,b   Corby, Patricia M ^b,c   Shah, Sonal S ^b   Epler, Monika ^b   Fisch, Gene S ^b   Norman, Robert G ^b  

^a Department of Oral and Maxillofacial Pathology Radiology and Medicine   (United States)

^b NEW YORK UNIVERSITY COLLEGE OF DENTISTRY   (United States)

^c Schwartz Building ^*  (United States)

Author keywords

Bioadhesive; Crossover trial; Dry mouth; Efficacy; Mucoadhesive; Randomized controlled trial; Safety; Salivary flow; Xerostomia

Indexed keywords

EID: 77958535223     PISSN: 00028177     EISSN: None     Source Type: Journal    
DOI: 10.14219/jada.archive.2010.0053     Document Type: Article

References (13)

1. Dawes C. Physiological factors affecting salivary flow rate, oral sugar clearance, and the sensation of dry mouth in man. J Dent Res 1987; 66 spec no:648-653.
2. Sreebny LM. Dry mouth and salivary gland hypofunction, part II: etiology and patient evaluation. Compendium 1988; 9 (8): 630-631, 634-635, 638.
3. Nederfors T. Xerostomia and hyposalivation. Adv Dent Res 2000; 14: 48-56.
4. Ship JA, Diagnosing, managing, and preventing salivary gland disorders. Oral Dis 2002; 8 (2): 77-89.
5. Porter SR, Scully C, Hegarty AM. An update of the etiology and management of xerostomia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004; 97 (1): 28-46.
6. Wolff A, Zuk-Paz L, Kaplan I. Major salivary gland output differs between users and non-users of specific medication categories. Gerodontology 2008; 25 (4): 210-216.
7. Guggenheimer J, Moore PA. Xerostomia: etiology, recognition and treatment. JADA 2003; 134 (1): 61-69.
8. OraMoist Time Released Dry Mouth Patch (product packaging). Eugene, Ore.: Quantum Health (distributor).
9. Aframian DJ, Mizrahi B, Granot I, Domb AJ. Evaluation of a mucoadhesive lipid-based bioerodable tablet compared with Biotène mouthwash for dry mouth relief: a pilot study. Quintessence Int 2010; 41 (3): e36-e42.
10. Ship JA, Corby PM, Fisch GS, et al. Reliability and validity of Mouthfeel questionnaire with salivary flow rates (abstract 1255). Abstract presented at: International Association for Dental Research 87th General Session and Exhibition; April 2, 2009; Miami. "http://iadr.confex.com/iadr/2009miami/ webprogram/Paper118527.html". Accessed Aug. 31, 2010.
11. Navazesh M, Kumar SK; University of Southern California School of Dentistry. Measuring salivary flow: challenges and opportunities. JADA 2008; 139 (suppl): 35S-40S.
12. Sudhakar Y, Kuotsu K, Bandyopadhyay AK. Buccal bioadhesive drug delivery: a promising option for orally less efficient drugs. J Control Release 2006; 114 (1): 15-40.
13. Mizrahi B, Domb AJ. Mucoadhesive polymers for delivery of drugs to the oral cavity. Recent Pat Drug Deliv Formul 2008; 2 (2): 108-119.