Comparison of the activity of non-steroidal ecdysone agonists between dipteran and lepidopteran insects, using cell-based EcR reporter assays

Pest Management Science

Volumn 66, Issue 11, 2010, Pages 1215-1229

  Soin, Thomas ^a   Swevers, Luc ^b   Kotzia, Georgia ^b   Iatrou, Kostas ^b   Janssen, Colin R ^a   Rougé, Pierre ^c   Harada, Toshiyuki ^d   Nakagawa, Yoshiaki ^d   Smagghe, Guy ^a  

^a GHENT UNIVERSITY   (Belgium)

^b INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^c Centre National de la Recherche Scientifique   (France)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

Dipteran cell line; Drosophila melanogaster; Ecdysone agonist; Insect growth regulator; Moulting accelerating compound

Indexed keywords

AGONISTIC BEHAVIOR; BIOASSAY; COMPARATIVE STUDY; FLY; GROWTH REGULATOR; HORMONE; LIGAND; PHEROMONE;

BOMBYX MORI; DIPTERA; DROSOPHILA MELANOGASTER; HEXAPODA; LEPIDOPTERA;

EID: 77958514619     PISSN: 1526498X     EISSN: 15264998     Source Type: Journal    
DOI: 10.1002/ps.1998     Document Type: Article

References (45)

1. Yao TP, Forman BM, Jiang Z, Cherbas L, Chen JD, McKeown M, et al., Functional ecdysone receptor is the product of EcR and Ultraspiracle genes. Nature 366: 476-479 (1993).
2. Dhadialla TS, Carlson GR and Le DP, New insecticides with ecdysteroidal and juvenile hormone activity. Annu Rev Entomol 43: 545-569 (1998).
3. Nakagawa Y, Nonsteroidal ecdysone agonists. Vitam Horm 73: 131-173 (2005).
4. Billas IM, Iwema T, Garnier JM, Mitschler A, Rochel N and Moras D, Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor. Nature 426: 91-96 (2003).
5. Carmichael JA, Lawrence MC, Graham LD, Pilling PA, Epa VC, Noyce L, et al., The X-ray structure of a hemipteran ecdysone receptor ligand-binding domain: comparison with a lepidopteran ecdysone receptor ligand-binding domain and implications for insecticide design. J Biol Chem 280: 22 258-22 269 (2005).
6. Smith HC, Cavanaugh CK, Friz JL, Thompson CS, Saggers JA, Michelotti EL, et al., Synthesis and SAR of cis-1-benzoyl-1, 2, 3, 4-tetrahydroquinoline ligands for control of gene expression in ecdysone responsive systems. Bioorg Med Chem Lett 13: 1943-1946 (2003).
7. Tice CM, Hormann RE, Thompson CS, Friz JL, Cavanaugh CK, Michelotti EL, et al., Synthesis and SAR of alpha-acylaminoketone ligands for control of gene expression. Bioorg Med Chem Lett 13: 475-478 (2003).
8. Tice CM, Hormann RE, Thompson CS, Friz JL, Cavanaugh CK and Saggers JA, Optimization of α-acylaminoketone ecdysone agonists for control of gene expression. Bioorg Med Chem Lett 13: 1883-1886 (2003).
9. Swevers L, Kravariti L, Ciolfi S, Xenou-Kokoletsi M, Ragoussis N, Smagghe G, et al., A cell-based high-throughput screening system for detecting ecdysteroid agonists and antagonists in plant extracts and libraries of synthetic compounds. FASEB J 18: 134-136 (2004).
10. Soin T, Iga M, Swevers L, Rougé P, Janssen CR and Smagghe G, Towards Coleoptera-specific high-throughput screening systems for compounds with ecdysone activity: development of EcR reporter assays using weevil (Anthonomus grandis)-derived cell lines and in silico analysis of ligand binding to A. grandis EcR ligand-binding pocket. Insect Biochem Mol Biol 39: 523-534 (2009).
11. Dinan L, Bourne P, Whiting P, Dhadialla TS and Hutchinson TH, Screening of environmental contaminants for ecdysteroid agonist and antagonist activity using the Drosophila melanogaster B(II) cell in vitro assay. Environ Toxicol Chem 20: 2038-2046 (2001).
12. Poels J, Martinez A, Suner MM, De Loof A, Dunbar SJ and Vanden Broeck J, Functional and comparative analysis of two distinct ecdysteroid-responsive gene expression constructs in Drosophila S2 cells. Insect Biochem Mol Biol 34: 451-458 (2004).
13. Soin T, Swevers L, Mosallanejad H, Efrose R, Labropoulou V, Iatrou K, et al., Juvenile hormone analogs do not affect directly the activity of the ecdysteroid receptor complex in insect culture cell lines. J Insect Physiol 54: 429-438 (2008).
14. Ostyn B, Vanlerberghe V, Picado A, Dinesh DS, Sundar S, Chappuis F, et al., Vector control by insecticide-treated nets in the fight against visceral leishmaniasis in the Indian subcontinent, what is the evidence? Trop Med Int Health 13: 1073-1085 (2008).
15. The use of DDT in malaria vector control. WHO Position Statement (2007).
16. Saleh MC, van Rij RP, Hekele A, Gillis A, Foley E, O'Farrell PH, et al., The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Nat Cell Biol 8: 793-802 (2006).
17. Foley E and O'Farrell PH, Functional dissection of an innate immune response by a genome-wide RNAi screen. PLoS Biol 2: E203 (2004).
18. Wheelock CE, Nakagawa Y, Harada T, Oikawa N, Akamatsu M, Smagghe G, et al., High-throughput screening of ecdysone agonists using a reporter gene assay followed by 3-D QSAR analysis of the molting hormonal activity. Bioorg Med Chem 14: 1143-1159 (2006).
19. Soin T, De Geyter E, Mosallanejad H, Iga M, Martin D, Ozaki S, et al., Assessment of species specificity of moulting accelerating compounds in Lepidoptera: comparison of activity between Bombyx mori and Spodoptera littoralis by in vitro reporter and in vivo toxicity assays. Pest Manag Sci 66: 526-535 (2010).
20. Heberlein U, England B and Tjian R, Characterization of Drosophila transcription factors that activate the tandem promoters of the alcohol dehydrogenase gene. Cell 41: 965-977 (1985).
21. Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F and Higgins DG, The CLUSTAL-X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tool. Nucleic Acids Res 15: 4876-4882 (1997).
22. Risler J-L, Delorme MO, Delacroix H and Henaut A, Amino acid substitutions in structurally related proteins. A pattern recognition approach. Determination of a new and efficient scoring matrix. J Mol Biol 204: 1019-1029 (1998).
23. Koelle MR, Talbot WS, Segraves WA, Bender MT, Cherbas P and Hogness DS, The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily. Cell 67: 59-77 (1991).
24. Swevers L, Drevet JR, Lunke MD and Iatrou K, The silkmoth homolog of the Drosophila ecdysone receptor (B1 isoform): cloning and analysis expression during follicular cell differentiation. Insect Biochem Mol Biol 25: 857-866 (1995).
25. Ponder JW and Richards FM, Tertiary templates for proteins. Use of packing criteria in the enumeration of allowed sequences for different structural classes. J Mol Biol 193: 775-791 (1987).
26. Mas MT, Smith KC, Yarmush DL, Aisaka K and Fine RM, Modeling the anti-CEA antibody combining site by homology and conformational search. Proteins Struc Func Genet 14: 483-498 (1992).
27. Laskowski RA, MacArthur MW, Moss DS and Thornton JM, PROCHECK: a program to check the stereochemistry of protein structures. J Appl Cryst 26: 283-291 (1993).
28. Bennett-Lovsey RM, Hebert AD, Stemberg MJE and Kelley LA, Exploring the extremes of sequence/structure space with ensemble fold recognition in the program Phyre. Proteins Struct Funct Bioinformatics 70: 611-625 (2008).
29. Mikitani K, A new nonsteroidal chemical class of ligand for the ecdysteroid receptor 3, 5-di-tert-butyl-4-hydroxy-N-isobutyl-benzamide shows apparent insect molting hormone activities at molecular and cellular levels. Biochem Biophys Res Commun 227: 427-432 (1996).
30. Sundaram M, Palli SR, Krell PJ, Sohi SS, Dhadialla TS and Retnakaran A, Basis for selective action of a synthetic molting hormone agonist, RH-5992, on lepidopteran insects. Insect Biochem Mol Biol 28: 693-704 (1998).
31. Browning C, Martin E, Loch E, Wurtz J-M, Moras D, Stote RH, et al., Critical role of desolvation in the binding of 20-hydroxyecdysone to the ecdysone receptor. J Biol Chem 282: 32 924-32 934 (2007).
32. Beckage NE, Marion KM, Walton WE, Wirth MC and Tan FF, Comparative larvicidal toxicities of three ecdysone agonists on the mosquitoes Aedes aegypti, Culex quinquefasciatus, and Anopheles gambiae. Arch Insect Biochem Physiol 57: 111-122 (2004).
33. Hormann RE, Dinan L and Whiting P, Superimposition evaluation of ecdysteroid agonist chemotypes through multidimensional QSAR. J Comput Aided Mol Des 17: 135-153 (2003).
34. Braeckman B, Simoens C, Rzeznik U and Raes H, Effect of sublethal doses of cadmium, inorganic mercury and methyl mercury on the cell morphology of an insect cell line (Aedes albopictus, C6/36). Cell Biol Internat 21: 823-832 (1997).
35. 3H]ponasterone A binding by ecdysone agonists in the intact Kc cell line. Insect Biochem Mol Biol 32: 175-180 (2002).
36. Hormann RE, Smagghe G and Nakagawa Y, Multidimensional quantitative structure-activity relationships of diacylhydrazine toxicity in Spodoptera exigua, Chilo suppressalis, and Leptinotarsa decemlinata. QSAR Comb Sci 27: 1098-1112 (2008).
37. Nakagawa Y, Hormann RE and Smagghe G, SAR and QSAR studies for in vivo and in vitro activities of ecdysone agonists, in Ecdysone: Structures and Functions, ed. by Smagghe G. Springer-Verlag, Dordrecht, The Netherlands, pp. 475-509 (2009).
38. Bonneton F, Zelus D, Iwema T, Robinson-Rechavi M and Laudet V, Rapid divergence of the ecdysone receptor in Diptera and Lepidoptera suggests coevolution between ECR and USP-RXR. Mol Biol Evol 20: 541-553 (2003).
39. Bonneton F, Brunet FG, Kathirithamby J and Laudet V, The rapid divergence of the ecdysone receptor is a synapomorphy for Mecopterida that clarifies the Strepsiptera problem. Insect Mol Biol 15: 351-362 (2006).
40. Retnakaran A, Gelbic I, Sundaram M, Tomkins W, Ladd T, Primavera M, et al., Mode of action of the ecdysone agonist tebufenozide (RH-5992), and an exclusion mechanism to explain resistance to it. Pest Manag Sci 57: 951-957 (2001).
41. Hakim RS, Baldwin K and Smagghe G, Regulation of midgut growth, development, and metamorphosis. Annu Rev Entomol 55: 593-608 (2010).
42. Smagghe G, Carton B, Decombel L and Tirry L, Significance of absorption, oxidation and binding to toxicity of four ecdysone agonists in multi-resistant cotton leafworm. Arch Insect Biochem Physiol 46: 127-139 (2001).
43. Schneider MI, Smagghe G, Gobbi A and Viñuela E, Toxicity and pharmacokinetics of insect growth regulators and other novel insecticides on pupae of Hyposoter didymator (Hymenoptera: Ichneumonidae), a parasitoid of early larval stages of lepidopteran pests. J Econ Entomol 96: 1054-1065 (2003).
44. Medina P, Smagghe G, Budia F, Tirry L and Viñuela E, Toxicity and penetration of azadirachtin, diflubenzuron, pyriproxyfen, and tebufenozide after topical application in predatory larvae of Chrysoperla carnea (Neuroptera: Chrysopidae). Envir Entomol 32: 196-203 (2003).
45. Iwema T, Billas IM, Beck Y, Bonneton F, Nierengarten H, Chaumot A, et al., Structural and functional characterization of a novel type of ligand-independent RXR-USP receptor. EMBO J 26: 3770-3782 (2007).