Biphasic effects of ankaferd blood stopper on renal tubular apoptosis in the rat partial nephrectomy model representing distinct levels of hemorrhage

Saudi Medical Journal

Volumn 31, Issue 8, 2010, Pages 864-868

  Huri, Emre ^a   Haznedaroglu, Ibrahim C ^a   Akgul, Turgay ^a   Astarci, Muzeyyen ^a   Ustun, Huseyin ^a   Germiyanoulu, Cankon ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ANKAFERD; ANTICOAGULANT AGENT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG; ANKAFERD BLOOD STOPPER; PLANT EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLEEDING; DRUG EFFECT; HISTOPATHOLOGY; KIDNEY ISCHEMIA; KIDNEY TUBULE; NONHUMAN; PARTIAL NEPHRECTOMY; PROTEIN EXPRESSION; RAT; SURGICAL TECHNIQUE; ANIMAL; IMMUNOHISTOCHEMISTRY; NEPHRECTOMY; PATHOLOGY; PATHOPHYSIOLOGY; WISTAR RAT;

ANIMALS; APOPTOSIS; HEMORRHAGE; IMMUNOHISTOCHEMISTRY; KIDNEY TUBULES; NEPHRECTOMY; PLANT EXTRACTS; RATS; RATS, WISTAR;

EID: 77958512426     PISSN: 03795284     EISSN: 16583175     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Huri E, Akgül T, Ayyildiz A, Ustün H, Germiyanožlu C. Hemostatic role of a folkloric medicinal plant extract in a rat partial nephrectomy model: controlled experimental trial. J Urol 2009; 181: 2349-2354.
2. Goker H, Haznedaroglu IC, Ercetin S, Kirazli S, Akman U, Ozturk Y, et al. Haemostatic actions of the folkloric medicinal plant extract ankaferd blood stopper. J Int Med Res 2008; 36: 163-170.
3. Cipil HS, Kosar A, Kaya A, Uz B, Haznedaroglu IC, Goker H, et al. In vivo hemostatic effect of the medicinal plant extract Ankaferd Blood Stopper in rats pretreated with warfarin. Clin Appl Thromb Hemost 2009; 15: 270-276.
4. Kosar A, Cipil HS, Kaya A, Uz B, Haznedaroglu IC, Goker H, et al. The efficacy of Ankaferd Blood Stopper in antithrombotic drug-induced primary and secondary hemostatic abnormalities of a rat-bleeding model. Blood Coagul Fibrinolysis 2009; 20: 185-190.
5. Haznedaroglu BZ, Haznedaroglu IC, Walker SL, Bilgili H, Goker H, Kosar A, et al. Ultrastructural and Morphological Analyses of the In Vitro and In Vivo Hemostatic Effects of Ankaferd Blood Stopper. Clin Appl Thromb Hemost 2009; 14. [Epub ahead of print]
6. Akkoc N, Akceik M, Haznedaroglu I, Goker H, Aksu S, Kirazli S, et al. In vitro anti-bacterial activities of ankaferd blood stopper. Int J Lab Hematol 2008; 30: 95.
7. Tasdelen Fisgin N, Tanriverdi Cayci Y, Coban AY, Ozatli D, Tanyel E, Durupinar B, et al. Antimicrobial activity of plant extract Ankaferd Blood Stopper. Fitoterapia 2009; 80: 48-50.
8. Turhan N, Kurt M, Shorbagi A, Akdogan M, Haznedaroglu IC. Topical Ankaferd Blood Stopper administration to bleeding gastrointestinal carcinomas decreases tumor vascularization. Am J Gastroenterol 2009; 104: 2874-2877.
9. Leibovich BC, Blute ML, Cheville JC, Lohse CM, Weaver AL, Zincke H. Nephron sparing surgery for appropriately selected renal cell carcinoma between 4 and 7 cm results in outcome similar to radical nephrectomy. J Urol 2004; 171: 1066-1070.
10. Akgül T, Karagüzel E, Sürer H, Yažmurdur H, Ayyildiz A, Ustün H, et al. Int Urol Nephrol 2009; 41: 531-536.
11. Pagliaro P. Differential biological effects of products of nitric oxide (NO) synthase: it is not enough to say NO. Life Sci 2003; 73: 2137-2149.
12. Aktas A, Er N, Onur MA. Effects of ankaferd blood stopper on vascular response in rat carotid artery. International Journal of Hematology and Oncology 2009. (In press).
13. Cahill J, Calvert JW, Solaroglu I, Zhang JH. Vasospasm and p53-induced apoptosis in an experimental model of subarachnoid hemorrhage. Stroke 2006; 37: 1868-1874.
14. Yi{dotless}lmaz E, Gulec S, Haznedaroglu IC, Akar N. Effects of ankaferd on huvec transcription factors and erythrocyte protein profile. In: Haznedaroglu IC, Goker H, Ozdemir O, Kosar A, Firat H, editors. Ankaferd: Scientific perspectives and basic-clinical data. Istanbul: Naviga Publications; 2008. p. 60.
15. Bilgili H, Kosar A, Kurt M, Onal IK, Goker H, Captug O, et al. Hemostatic efficacy of Ankaferd Blood Stopper in a swine bleeding model. Med Princ Pract 2009; 18: 165-169.
16. Arslan S, Haznedaroglu IC, Oz B, Goker H. Endobronchial application of ankaferd blood stopper to control profuse lung bleeding leading to hypoxemia and hemodynamic instability. Respiratory Medicine 2009; 2: 144-146.
17. Huri E, Akgül T, Ayyildiz A, Germiyanožlu C. Hemostasis in retropubic radical prostatectomy with Ankaferd BloodStopper: a case report. Kaohsiung J Med Sci 2009; 25: 445-447.
18. Kurt M, Akdogan M, Onal IK, Kekilli M, Arhan M, Shorbagi A, et al. Endoscopic topical application of Ankaferd Blood Stopper for neoplastic gastrointestinal bleeding: A retrospective analysis. Dig Liver Dis 2010; 42: 196-199.
19. Turgut M, Tutkun F, Çelebi N, Mužlali{dotless} M, Goker H, Haznedaroglu IC. Topical ankaferd bloodstopper in the management of critical bleedings due to hemorrhagic diathesis. UHOD Int J Hematol Oncol 2009; In press.
20. Hsieh YC, Athar M, Chaudry IH. When apoptosis meets autophagy: deciding cell fate after trauma and sepsis. Trends Mol Med 2009; 15: 129-138.
21. Lu Q, Xu DZ, Davidson MT, Haskó G, Deitch EA. Hemorrhagic shock induces endothelial cell apoptosis, which is mediated by factors contained in mesenteric lymph. Crit Care Med 2004; 32: 2464-2670.
22. Rekha K, Malini A, Xavier R, Baba K. Apoptosis in endometria of dysfuntional uterine bleeding women. Med J Malaysia 2005; 60: 41-45.
23. Ayuste EC, Chen H, Koustova E, Rhee P, Ahuja N, Chen Z, et al. Hepatic and pulmonary apoptosis after hemorrhagic shock in swine can be reduced through modifications of conventional ringer's solution. J Trauma 2006; 60: 52-63.
24. Ballesteros MA, Lopez-Hoyos M, Munoz P, Marin MJ, Minambres E. Apoptosis of neuronal cells induced by serum of patients with acute brain injury: A new in vitro prognostic model. Intensive Care Med 2007; 33: 58-65.
25. Robinson Y, Matenov A, Tschoke SK, Weimann A, Oberholzer A, Ertel W, et al. Impaired erythropoiesis after haemorrhagic shock in mice is associated with erythroid progenitor apoptosis in vivo. Acta Anaesthesiol Scand 2008; 52: 605-613.
26. Butt MU, Sailhamer EA, Li Y, Liu B, Shuja F, Velmahos GC, et al. Pharmacologic resuscitation: cell protective mechanisms of histone deacetylase inhibition in lethal hemorrhagic shock. J Surg Res 2009; 156: 290-296.
27. Gonzales ER, Chen H, Munuve RM, Mehrani T, Nadel A, Koustova E. Hepatoprotection and lethality rescue by histone deacetylase inhibitor valproic acid in fatal hemorrhagic shock. J Trauma 2008; 65: 554-565.
28. Lin CL, Dumont AS, Su YF, Dai ZK, Cheng JT, Tsai YJ, et al. Attenuation of subarachnoid hemorrhage-induced apoptotic cell death with 17 beta-estradiol. Laboratory investigation. J Neurosurg 2009; 111: 1014-1022.
29. Haznedaroglu BZ, Haznedaroglu IC, Walker SL, Bilgili H, Goker H, Kosar A, et al. Ultrastructural and Morphological Analyses of the In Vitro and In Vivo Hemostatic Effects of Ankaferd Blood Stopper. Clin Appl Thromb Hemost 2009; 14.
30. Ibis M, Kurt M, Onal IK, Haznedaroglu IC. Successful management of bleeding due to solitary rectal ulcer via topical application of Ankaferd blood stopper. J Altern Complement Med 2008; 14: 1073-1074.
31. Akar N, Demiralp DO, Haznedaroglu IC, Goker H. Functional proteomics of ankaferd blood stopper. Blood 2008; 112: 4103.
32. Haznedaroglu IC. Molecular basis of the pleiotropic effects of ankaferd blood stopper. IUBMB Life 2009; 61: 290.