Patterns of self-medication with medicinal plants and related adverse events - A South American survey

Current Drug Safety

Volumn 5, Issue 4, 2010, Pages 333-341

  Consolini, Alicia E ^a   Ragone, María Inés ^a  

^a FACULTAD DE CIENCIAS EXACTAS   (Argentina)

Author keywords

Adverse reactions; Contraindications; Medicinal plants; Phytotherapy; Self medication

Indexed keywords

ALOYSIA CITRIODORA EXTRACT; ALTERNANTHERA PUNGENS EXTRACT; ARCTOSTAPHYLOS UVA URSI EXTRACT; BACCHARIS ARTICULATA EXTRACT; CASCARA SAGRADA; CASSIA EXTRACT; CECROPIA PACHYSTACHYA EXTRACT; CERATONIA SILIQUA EXTRACT; EQUISETUM ARVENSE EXTRACT; EUCALYPTUS EXTRACT; GINKGO BILOBA EXTRACT; GINSENG EXTRACT; GREEN TEA EXTRACT; HERBACEOUS AGENT; ISPAGULA; LEPECHINIA GRAVEOLENS EXTRACT; MALVA SYLVESTRIS EXTRACT; MATRICARIA RECUTITA EXTRACT; MELISSA OFFICINALIS EXTRACT; PEUMUS BOLDUS EXTRACT; PLANT EXTRACT; QUASSIA AMARA EXTRACT; RHAMMUS PURSHIANA EXTRACT; SENNA EXTRACT; SPHACELE ACUMINATA EXTRACT; ST. JOHNS WORT EXTRACT; TILIA CORDATA EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALERIAN; ZEA MAYS EXTRACT;

ABDOMINAL CRAMP; ALLERGIC REACTION; ALLERGY; ALOYSIA CITRIODORA; ALTERNANTHERA PUNGENS; ALZHEIMER DISEASE; ANOREXIA; ANTIINFLAMMATORY ACTIVITY; ANXIETY DISORDER; ARCTOSTAPHYLOS UVA URSI; ARGENTINA; ARTICLE; ASTHENIA; ASTHMA; BACCHARIS; BARK; BURN; CECROPIA; CERATONIA SILIQUA; COLIC; CONFUSION; CONSTIPATION; CONVULSION; COUGHING; DEHYDRATION; DEPERSONALIZATION; DEPRESSION; DIARRHEA; DIURESIS; DIZZINESS; DROWSINESS; DRUG ACTIVITY; DRUG EFFECT; DRUG MEGADOSE; DRUG OVERDOSE; DRUG POTENTIATION; DRUG WITHDRAWAL; DYSPEPSIA; DYSPHAGIA; EQUISETUM; ERIODICTYON; EUCALYPTUS; EUPHORIA; FATIGUE; FLATULENCE; FLAX; GASTROINTESTINAL DISEASE; GINGIVITIS; GINKGO BILOBA; GINSENG; GLOSSITIS; HALLUCINATION; HAMAMELIS; HEADACHE; HEART PALPITATION; HUMAN; HYPERGLYCEMIA; HYPERICUM PERFORATUM; HYPERSENSITIVITY; HYPERTENSION; HYPOCALCEMIA; HYPOGLYCEMIA; HYPOTENSION; ILLICIUM VERUM; INSOMNIA; INSULIN RESISTANCE; KELP; LEPECHINIA GRAVEOLENS; LIVER DISEASE; LIVER TOXICITY; MAIZE; MALVA; MASTALGIA; MATRICARIA; MEDICINAL PLANT; MYOPATHY; NAUSEA; NIGHTMARE; NONHUMAN; OBESITY; PEDICULOSIS; PEUMUS BOLDUS; PHYTOTHERAPY; PLANT LEAF; PRESCRIPTION; PRIORITY JOURNAL; QUASSIA; RECOMMENDED DRUG DOSE; RHAMMUS PURSHIANA; RISK ASSESSMENT; SELF MEDICATION; SENNA; SIDE EFFECT; SOUTH AMERICA; SPHACELE ACUMINATA; STOMACH PAIN; STOMACH ULCER; STOMATITIS; TACHYCARDIA; TEA; TENESMUS; TILIACEAE; TINNITUS; TREATMENT CONTRAINDICATION; TREATMENT INDICATION; ULCER; VAGINA BLEEDING; VALERIANA; VALERIANA OFFICINALIS; VASCULITIS; VERTIGO; VOMITING; WOUND;

ADVERSE DRUG REACTION REPORTING SYSTEMS; ARGENTINA; HEALTH KNOWLEDGE, ATTITUDES, PRACTICE; HEALTH SURVEYS; HERB-DRUG INTERACTIONS; HUMANS; PATIENT EDUCATION AS TOPIC; PHYTOTHERAPY; PLANT PREPARATIONS; PLANTS, MEDICINAL; SELF MEDICATION;

EID: 77958488631     PISSN: 15748863     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488610792246019     Document Type: Article

References (60)

1. Newall C, Anderson L, Phillipson JD: Herbal Medicines: A Guide for Healthcare Professionals. London: The Pharmaceutical Press; 1996.
2. Capasso F, Gracinella T, Grandolini G, Izzo A: Phytotherapy. A quick Reference to Herbal Medicine. Berlin Heidelberg: Springer-Verlag; 2003.
3. Alonso J, Desmarchelier C: Plantas medicinales autóctonas de la Argentina. Buenos Aires: Literature of Latin America (L.O.L.A.); 2005.
4. Farah MH, Edwards R, Lindquist M, Leon C, Shaw D. International monitoring of adverse health effects associated with herbal medicines. Pharmacoepidemiol Drug Saf 2000; 9: 105-112.
5. Fugh Berman A, Ernst E. Herb-drug interactions: Review and assessment of report reliability. Br J Clin Pharmacol 2001; 52: 587-595.
6. Izzo AA. Herb-drug interactions: an overview of the clinical evidence. Fund & Clin Pharmacol 2004; 19: 1-16.
7. Izzo AA, Di Carlo G, Borrelli F, Ernst E. Cardiovascular pharmacotherapy and herbal medicines: the risk of drug interaction. Int J Cardiol 2005; 98: 1-14.
8. Tres JC. Interacción entre fármacos y plantas medicinales. An Sist Sanit Navar 2006; 29(2): 233-252.
9. Consolini AE, Ragone MI, Tambussi A, Paura A. Estudio observacional del consumo de plantas medicinales en la Provincia de Buenos Aires, Argentina, en el período Diciembre de 2004 - Noviembre de 2005. Lat Am J Pharm 2007; 26: 924-936.
10. Maiche AG, Grohn P, Maki-Hokkonen H. Effect of chamomile cream and almond ointment on acute radiation skin reaction. Acta Oncol 1991; 30: 395-396.
11. Fidler P, Loprinzi CL, O'Fallon JR, et al. Prospective evaluation of a chamomile mouthwash for prevention of 5-FU-induced oral mucositis. Cancer 1996; 77: 522-525.
12. Alonso J. Tratado de Fitomedicina. Buenos Aires: ISIS Ediciones SRL; 1998.
13. Viola H, Wasowski C, Levi de Stein M, et al. Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Med 1995; 61: 213-216.
14. Subiza J, Subiza JL, Hinojosa M, et al. Anaphylactic reaction after the ingestion of chamomile tea: a study of cross-reactivity with other composite pollens. J Allergy Clin Immunol 1989; 84: 353-358.
15. Scala G. Acute, short-lasting rhinitis due to chamomile-scented toilet paper in patients allergic to camomile-scented toilet paper in patients allergic to Compositae. Int Arch Allergy Immunol 2006; 139: 330-331.
16. Segal R, Pilote L. Warfarin interaction with Matricaria chamomile. CMAJ 2006; 174: 1281-1282.
17. Gupta MP: 270 plantas medicinales iberoamericanas. Santafé de Bogotá: CYTED-CECAB, 1995.
18. Lanhers MC, Joyeux M, Soulimani R, et al. Hepatoprotective and anti-inflammatory effects of a traditional medicinal plant of Chile, Peumus boldus. Planta Med 1991; 57:110-115.
19. De Almeida ER, Melo AM, Xavier H. Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats. Phytother Res 2000; 14: 99-102.
20. Soiche H, Leng Peschlow E. Characterization of flavonoids from Baccharis trimera and their anti-hepatotoxic properties. Planta Med 1987; 53: 37-39.
21. Lahitte HB, Hurrell JA, Belgrano MJ, Jankowski LS, Haloua P, Mehltreter K. Plantas medicinales rioplatenses. Buenos Aires: Literature of Latin America (L.O.L.A.); 2004.
22. Naranjo CA, Busto UE: Reacciones adversas a medicamentos: Naranjo CA: Métodos de farmacología clínica. Toronto: Service Science; 1992: 330-348.
23. Ragone MI, Sella M, Conforti P, Volonté MG, Consolini AE. The spasmolytic effect of Aloysia Citriodora, Palau (South American cedrón) is partially due to its vitexin but not isovitexin on rat duodenums. J Ethnopharmacol 2007; 113: 258-266.
24. Moraga FM, Ballesteros NB. Intoxicación por anís estrellado: A propósito de un caso en un recién nacido. Rev Chil Pediatr 2003; 74: 411-414.
25. Marzocca A. Vademecum de Malezas Medicinales de la Argentina Indígenas y Exóticas. Buenos Aires: Orientación Gráfica Editora; 1997.
26. Soraru SB, Bandoni AL: Plantas de la medicina popular argentina. Buenos Aires: Editorial Albatros. 1978.
27. EMEA (European Medicines Agency) monographs; 2006.
28. WHO monographs on selected medicinal plants. Geneva: World Health Organization; 1999.
29. Goodman & Gilman's The Pharmacological Basis of Therapeutics, 11th Edition. San Diego, CA: The McGraw-Hill; 2005.
30. Laitinen L, Takala E, Vuorela H, Vuorela P, Kaukonen AM, Marvola M. Anthranoid laxatives influence the absorption of poorly permeable drugs in human intestinal cell culture model (Caco-2). Eur J Pharm Biopharm 2007; 66: 135-145.
31. Vanderholzer WA, Schatke W, Muhldorfer BE, Klauser AG, Biorkner B, Muller-Lissner SA. Clinical response to dietary fiber treatment of chronic constipation. Am J Gastroenterol 1997; 92: 95-98
32. Alonso J. Tratado de Fitofármacos y Nutracéuticos. Rosario: Ediciones Corpus; 2004.
33. Viola H, Wolfman C, Levi de Stein M, Wasowski C, Peña C, Medina JH, Paladini AC. Isolation of pharmacologically active benzodiazepine receptor ligando from Tilia tomentosa (Tiliaceae). J Ethnopharmacol 1994; 44: 47-53.
34. Pérez-Ortega G, Guevara-Fefer P, Chávez M, et al. Sedative and anxiolytic efficacy of Tilia americana var.mexicana inflorescences used traditionally by communities of State of Michoacán, Mexico. J Ethnopharmacol 2008; 116: 461-468.
35. Trauner G, Khom S, Baburin I, Benedek B, Hering S, Kopp B. Modulation of GABA-A receptors by valerian extracts is related to the content of valerenic acid. Planta Med 2008; 74: 19-24.
36. Krystal AD, Ressler I. The use of valerian in neuropsychiatry. CNS Spectr 2001; 6: 841-847.
37. Jiang X, Williams KM, Liauw WS, et al. Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol 2004; 57: 592-599.
38. Consolini AE, Migliori GN. Cardiovascular effects of the South American medicinal plant Cecropia pachystachya (ambay) on rats. J Ethnopharmacol 2005; 96: 417-422.
39. Consolini AE, Ragone MI, Migliori GN, Conforti P, Volonte MG. Cardiotonic and sedative affects of Cecropia pachystchya Mart. (ambay) on isolated rat hearts and conscious mice. J Ethnopharmacol 2006; 106: 90-96.
40. Galdi E, Perfetti L, Calcagno G, Marcotulli MC, Moscato G. Exacerbation of asthma related to Eucalyptus pollens and to herb infusion containing Eucalyptus. Monaldi Arch Chest Dis 2003; 59: 220-221
41. Chiclana CF, Enrique A, Consolini AE. Actividad antiinflamatoria local de Malva sylvestris L. (Malvaceae) en el edema inducido por carragenina en ratas. Latin Am J Pharmacy 2009; 28: 275-278.
42. Ahlemeyer B, Krieglstein J. Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. Pharmacopsychiatry 2003; 36(Suppl 1): S8-14.
43. Yale SH, Glurich Y. Analysis of the inhibitory potential of Ginkgo biloba, Echinacea purpurea, and Serenoa repens on the metabolic activity of cytochrome P450 3A4, 2D6, and 2C9. J Altern Complement Med 2005; 11: 433-439
44. Dugoua JJ, Mills E, Perri D, Koren G. Safety and efficacy of ginkgo (Ginkgo biloba) during pregnancy and lactation. Can J Clin Pharmacol 2006; 13: e277-e284.
45. Radad K, Gille G, Liu L, Rausch W-D. Use of ginseng in medicine with emphasis on neurodegenerative disorders. J Pharmacol Sci 2006; 100: 175-186.
46. Kiefer D, Pantuso T. Panax ginseng. Am Fam Physician 2003; 68: 1539-1542
47. Chun-Su Y, Gang W, Lucy D, et al. Brief communication: American Ginseng Reduces warfarińs effect in healthy patients. Arandomized, controlled trial. Ann Intern Med 2004; 141: 23-27.
48. Sievenpiper JL, Arnason JT, Leiter LA, Vuksan V. Nul land opposing effects of Asian ginseng (Panax ginseng C.A. Meyer) on acute glycemia: results of two acute dose escalation studies. J Am Coll Nutr 2003; 22: 524-532.
49. Vuksan V, Stavro MP, Sievenpiper JL, et al. Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 Diabetes. Diabetes Care 2000; 23: 1221-1226.
50. Andrade ASA, Hendrix C, Parsons TL, et al. Pharmacokinetic and metabolic effects of American ginseng (Panax quinquifolius) in healthy volunteers receiving the HIV protease inhibitor indinavir. BMC Complement Altern Med 2008; 8: 50-60.
51. Moro CO, Basile G. Obesity and medicinal plants. Fitoterapia 2000; 71(Suppl 1): S73-82.
52. Zaragozá MC, López D, P Sáiz M, et al. Toxicity and antioxidant activity in vitro and in vivo of two Fucus vesiculosus extracts. J Agric Food Chem 2008; 56: 7773-7780.
53. Skibola CF. The effect of Fucus vesiculosus, an edible brown seaweed, upon menstrual cycle length and hormonal status in three pre-menopausal women: a case report. BMC Complement Altern Med 2004; 4: 10-18.
54. Heck AM, DeWitt DA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000; 57: 1221-1230.
55. Jang EH, Choi JY, Park CS, et al. Effects of green tea extract administration on the pharmacokinetics of clozapine in rats. J Pharm Pharmacol 2005; 57: 311-316.
56. Ninci ME. Prophylaxis and treatment of pediculosis with Quassia amarga. Rev Fac Cien Med Univ Nac Cordoba 1991; 49: 27-31.
57. Bertani S, Houël E, Bourdy G, et al. Quassia amara L. (Simaroubaceae) leaf tea: effect of the growing stage and desiccation status on the antimalarial activity of a traditional preparation. J Ethnopharmacol 2007; 111: 40-42.
58. Jensen O, Nielsen AO, Bjerregaard P. Pediculosis capitis treatedwith quassia tincture. Acta Derm Venereol 1978; 58: 557-559.
59. Raji Y, Bolarinwa AF. Antifertility activity of Quassia amara in male rats -in vivo study. Life Sci 1997; 61: 1067-1074.
60. Njar VC, Alao TO, Okogun JI, Raji Y, Bolarinwa AF, Nduka EU.Antifertility activity of Quassia amara: quassin inhibits the steroidogenesis in rat Leydig cells in vitro. Planta Med 1995; 61: 180-182.