Window to the brain: Can retinopathy be used to assess cognitive function

Brain Injury

Volumn 24, Issue 12, 2010, Pages 1448-1454

  Fergenbaum, Jennifer H ^a   Bruce, Sharon ^b   Lou, Wendy ^a   Hanley, Anthony J G ^a,c   Greenwood, Carol ^c   Young, T Kue ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cardiovascular; Clock Drawing Test; Cognitive function; Retinopathy; Risk factors; Trail Making Test

Indexed keywords

ADULT; ANTHROPOMETRY; ARTICLE; BLOOD ANALYSIS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CAROTID ATHEROSCLEROSIS; CLINICAL ARTICLE; CLINICAL EXAMINATION; COGNITION; COLOR ULTRASOUND FLOWMETRY; CONTROLLED STUDY; DIABETES MELLITUS; EYE FUNDUS; EYE PHOTOGRAPHY; FEMALE; HUMAN; INSULIN RESISTANCE; INTERVIEW; MALE; RETINOPATHY; RISK FACTOR;

EID: 77958483331     PISSN: 02699052     EISSN: 1362301X     Source Type: Journal    
DOI: 10.3109/02699052.2010.523044     Document Type: Article

References (38)

1. Qiu C, Winbald B, Fratiglioni L. The age-dependent relation of blood pressure to cognitive function and dementia. Lancet Neurology 2005;4:487-499.
2. Beydoun MA, Beydoun HA, Wang Y. Obesity and central obesity as risk factors for incident dementia and its subtypes: A systematic review and meta-analysis. Obesity Reviews 2008;9:204-218.
3. Cukierman T, Gerstein HC, Williamson JD. Cognitive decline and dementia in diabetes-systematic overview of prospective observational studies. Diabetologia 2005;48: 2460-2469.
4. Alvarez JA, Emory E. Executive function and the frontal lobes: A meta-analytic review. Neuropsychology Review 2006;16:17-42.
5. Wong TY, Klein R, Couper DJ, Cooper LS, Shahar E, Hubbard LD, Wofford MR, Sharrett RA. Retinal microvas-cular abnormalities and incident stroke: The Atherosclerosis Risk in Communities Study. Lancet 2001;358:1134-1140.
6. Patel MD, Coshall C, Rudd AG, Wolfe CDA. Cognitive impairment after stroke: Clinical determinants and its associations with long-term stroke outcomes. Journal of the American Geriatrics Society 2002;50:700-706.
7. Patton N, Aslam T, MacGillivray T, Pattie A, Deary IJ, Dhillon B. Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: A rationale based on homology between cerebral and retinal microvasculatures. Journal of Anatomy 2005;206:319-348.
8. Mohamed Q, Gillies MC, Wong TY. Management of diabetic retinopathy. A systematic review. Journal of the American Medical Association 2007;298:902-916.
9. Ding J, Patton N, Deary IJ, Strachan MWJ, Fowkes FGR, Mitchell RJ, Price JF. Retinal microvascular abnormalities and cognitive dysfunction: A systematic review. British Journal of Ophthalmology 2008;92:1017-1025.
10. Bruce SG, Young KT. Prevalence and risk factors for neuropathy in a Canadian First Nation community. Diabetes Care 2008;31:1837-1841.
11. Watson YI, Arfken CL, Birge SJ. Clock completion: An objective screening test for dementia. Journal of the American Geriatrics Society 1993;41:1235-1240.
12. Reitan RM. Validity of the trail making test as an indicator of organic brain damage. Perceptual and Motor Skills 1958;8: 271-276.
13. Bursell SE, Cavallerano JD, Cavallerano AA, Clermont AC, Birkmire-Peters D, Aiello LP, Aiello LM. Joslin Vision Network Research Team. Stereo nonmydriatic digital-video color retinal imaging compared with early treatment diabetic retinopathy study seven standard field 35-mm stereo color photos for determining level of diabetic retinopathy. Ophthalmology 2001;108:572-585.
14. Hubbard LD, Brothers RJ, King WN, Clegg LX, Klein R, Cooper LS, Sharrett RA, Davis MD, Cai J. Atherosclerosis Risk in Communities Study Group. Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study. Ophthalmology 1999;106:2269-2280.
15. Early Treatment Diabetic Retinopathy Study Research Group. Fundus photographic risk factors for progression of diabetic retinopathy. ETDRS report number 12. Ophthalmology 1991, 98(Suppl 5): 823-833
16. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Journal of the American Medical Association 2001;285:2486-2497.
17. National Institutes of Health. Identification, evaluation and treatment of overweight and obesity in adults. 2000; NIH Publication No. 00-4084.
18. Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care 2004;27:1487-1495.
19. Landry A, Spence JD, Fenster A. Measurement of carotid plaque volume by 3-dimensional ultrasound. Stroke 2004;35: 864-869.
20. Landry A, Fenster A. Theoretical and experimental quantification of carotid plaque volume measurements made by three-dimensional ultrasound using test phantoms. Medical Physics 2002;29:2319-2327.
21. Grant EG, Benson CB, Moneta GL, Alexandrov AV, Baker JD, Bluth EI, Carroll BA, Eliasziw M, Gocke J, Hertzberg BS, et al. Carotid artery stenosis: Gray-scale and doppler US diagnosis-Society of Radiologists in Ultrasound Consensus Conference. Radiology 2003;229:340-346.
22. Baker ML, Marino Larsen EK, Kuller LH, Klein R, Klein BEK, Siscovick DS, Bernick C, Manolio TA, Wong TY. Retinal microvascular signs, cognitive function, and dementia in older persons. Stroke 2007;38:2041-2047.
23. Joy S, Fein D, Kaplan E. Decoding digit symbol. Assessment 2003;10:56-65.
24. Shulman KI. Clock-drawing: Is it the ideal cognitive screening test? International Journal of Geriatric Psychiatry 2000;15:548-561.
25. Stuss DT, Bisschop SM, Alexander MP, Levine B, Katz D, Izukawa D. The trail making test: A study in focal lesion patients. Psychological Assessment 2001;13:230-239.
26. Wong TY, Klein R, Sharrett RA, Nieto JF, Boland LL, Couper DJ, Mosley TH, Klein BEK, Hubbard LD, Szklo M. Retinal microvascular abnormalities and cognitive impairment in middle-aged persons. Stroke 2002;33:1487-1492.
27. Wong TY, Klein R, Klein BEK, Tielsch JM, Hubbard L, Nieto JF. Retinal microvascular abnormalities and their relationship with hypertension, cardiovascular disease, and mortality. Survey Ophthalmology 2001;46:59-80.
28. Song Y, Manson JE, Tinker L, Howard BV, Kuller LH, Nathan L, Rifai N, Liu S. Insulin sensitivity and insulin secretion determined by the homeostasis model of assessment and risk of diabetes mellitus in a multiethnic cohort of women. Diabetes Care 2007;30:1747-1752.
29. Wong TY, Liew G, Tapp RJ, Schmidt MI, Wang JJ, Mitchell P, Klein R, Klein BEK, Zimmet P, Shaw J. Relation between fasting glucose and retinopathy for diagnosis of diabetes: Three population-based cross-sectional studies. Lancet 2008;371:736-743.
30. Leung H, Wang JJ, Rochtchina E, Wong TY, Klein R, Mitchell P. Dyslipidemia and microvascular disease in the retina. Eye 2005;19:861-868.
31. Cheung N, Wong TY. Obesity and eye diseases. Survey Ophthalmology 2007;52:180-195.
32. Wong TY, Duncan BB, Golden SH, Klein R, Couper DJ, Klein BEK, Hubbard LD, Sharrett RA, Schmidt MI. Associations between the metabolic syndrome and retinal microvascular signs: The Atherosclerosis Risk in Communities Study. Investigative Ophthalmology 2004;45: 2949-2954. (Pubitemid 39121821)
33. Lange RT, Iverson GL, Zakrzewski MJ, Ethel-King PE, Franzen MD. Interpreting the trail making test following traumatic brain injury: Comparison of traditional time scores and derived indices. Journal of Clinical and Experimental Neuropsychology 2005;27:897-906.
34. Perianez JA, Rios-Lago M, Rodriguez-Sanchez JM, Adrover-Roig D, Sanchez-Cubillo I, Crespo-Facorro B, Quemada JI, Barcelo F. Trail making test in traumatic brain injury, schizophrenia, and normal ageing: Sample comparisons and normative data. Archives of Clinical Neuropsychology 2007;22:433-447.
35. Naismith SL, Hickie IB, Turner K, Little CL, Winter V, Ward PB, Wilhelm K, Mitchell P, Parker G. Neuropsychological performance in patients with depression is associated with clinical, etiological and genetic risk factors. Journal of Clinical and Experimental Neuropsychology 2003;25:866-877.
36. Watkins PJ. Retinopathy. British Medical Journal 2003;326: 924-926.
37. Hester RL, Kinsella GJ, Ong B, McGregor J. Demographic influences on baseline and derived scores from the trail making test in healthy older Australian adults. Clinical Neuropsychology 2005;19:45-54.
38. Iverson GL, Lange RT, Green P, Franzen MD. Detecting exaggeration and malingering with the trail making test. Clinical Neuropsychology 2002;16:398-406.