The sodium channel β3-subunit induces multiphasic gating in Na V1.3 and affects fast inactivation via distinct intracellular regions

Journal of Biological Chemistry

Volumn 285, Issue 43, 2010, Pages 33404-33412

  Cusdin, Fiona S ^a,b,c   Nietlispach, Daniel ^a   Maman, Joseph ^a   Dale, Timothy J ^b,d   Powell, Andrew J ^b   Clare, Jeffrey J ^b   Jackson, Antony P ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c MEDIMMUNE   (United States)

^d Essen Instruments   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIPATHIC; BI-PHASIC; DORSAL ROOT GANGLION NEURONS; HEK293 CELLS; INTRACELLULAR DOMAIN; ION-CONDUCTING; ISOFORMS; MEMBRANE-BOUND; NERVE INJURIES; NMR SPECTROSCOPY; PHYSIOLOGICAL CONDITION; SODIUM CHANNEL; VOLTAGE SENSITIVITY; WHOLE CELL PATCH CLAMP;

ELECTROPHYSIOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURAL ANALYSIS;

TOXIC MATERIALS;

PROTEIN SUBUNIT; SODIUM CHANNEL; SODIUM CHANNEL BETA3; SODIUM CHANNEL NAV1.3; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; BETA CHAIN; CELL STRAIN HEK293; CHANNEL GATING; CIRCULAR DICHROISM; CONTROLLED STUDY; DEPOLARIZATION; ELECTRIC POTENTIAL; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; NERVE CELL EXCITABILITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; STRUCTURE ANALYSIS;

ANIMALS; CIRCULAR DICHROISM; GANGLIA, SPINAL; HUMANS; ION CHANNEL GATING; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PATCH-CLAMP TECHNIQUES; PROTEIN ISOFORMS; PROTEIN STRUCTURE, SECONDARY; RATS; SODIUM CHANNELS; UP-REGULATION;

RATTUS;

EID: 77958471998     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.114058     Document Type: Article

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