Memory B cells from older people express normal levels of cyclooxygenase-2 and produce higher levels of IL-6 and IL-10 upon in vitro activation

Cellular Immunology

Volumn 266, Issue 1, 2010, Pages 90-97

  Bancos, Simona ^a   Phipps, Richard P ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Antibody production; Cyclooxygenase 2; Elderly; Human B cells; IL 10; IL 6

Indexed keywords

CYCLOOXYGENASE 2; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 6; PROSTAGLANDIN E2;

ADULT; AGED; AGING; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MALE; MEMORY CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; SENESCENCE;

ADOLESCENT; ADULT; AGED; AGING; ANTIBODIES; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODY FORMATION; ANTIGENS, CD; ANTIGENS, CD19; ANTIGENS, CD27; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; B-LYMPHOCYTE SUBSETS; CELL PROLIFERATION; CYCLOOXYGENASE 2; DINOPROSTONE; FEMALE; HUMANS; INTERLEUKIN-10; INTERLEUKIN-6; LECTINS, C-TYPE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; OLIGODEOXYRIBONUCLEOTIDES; YOUNG ADULT;

EID: 77958458672     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2010.09.002     Document Type: Article

References (40)

1. Ryan E.P., Pollock S.J., Murant T.I., Bernstein S.H., Felgar R.E., Phipps R.P. Activated human B lymphocytes express cyclooxygenase-2 and cyclooxygenase inhibitors attenuate antibody production. J. Immunol. 2005, 174:2619-2626.
2. Harris S.G., Padilla J., Koumas L., Ray D., Phipps R.P. Prostaglandins as modulators of immunity. Trends Immunol. 2002, 23:144-150.
3. Davies P., Bailey P.J., Goldenberg M.M., Ford-Hutchinson A.W. The role of arachidonic acid oxygenation products in pain and inflammation. Annu. Rev. Immunol. 1984, 2:335-357.
4. Langman M.J. Ulcer complications and nonsteroidal anti-inflammatory drugs. Am. J. Med. 1988, 84:15-19.
5. Linton P.J., Dorshkind K. Age-related changes in lymphocyte development and function. Nat. Immunol. 2004, 5:133-139.
6. Frasca D., Blomberg B.B. Effects of aging on B cell function. Curr. Opin. Immunol. 2009, 21:425-430.
7. Franceschi C., Capri M., Monti D., Giunta S., Olivieri F., Sevini F., Panourgia M.P., Invidia L., Celani L., Scurti M., Cevenini E., Castellani G.C., Salvioli S. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech. Ageing Dev. 2007, 128:92-105.
8. Fagiolo U., Cossarizza A., Scala E., Fanales-Belasio E., Ortolani C., Cozzi E., Monti D., Franceschi C., Paganelli R. Increased cytokine production in mononuclear cells of healthy elderly people. Eur. J. Immunol. 1993, 23:2375-2378.
9. Paganelli R., Quinti I., Fagiolo U., Cossarizza A., Ortolani C., Guerra E., Sansoni P., Pucillo L.P., Scala E., Cozzi E., Bertollo L., Monti D., Franceschi C. Changes in circulating B cells and immunoglobulin classes and subclasses in a healthy aged population. Clin. Exp. Immunol. 1992, 90:351-354.
10. Colonna-Romano G., Bulati M., Aquino A., Scialabba G., Candore G., Lio D., Motta M., Malaguarnera M., Caruso C. B cells in the aged: CD27, CD5, and CD40 expression. Mech. Ageing Dev. 2003, 124:389-393.
11. Bancos S., Bernard M.P., Topham D.J., Phipps R.P. Ibuprofen and other widely used non-steroidal anti-inflammatory drugs inhibit antibody production in human cells. Cell. Immunol. 2009, 258:18-28.
12. Bernard M.P., Bancos S., Chapman T.J., Ryan E.P., Treanor J.J., Rose R.C., Topham D.J., Phipps R.P. Chronic inhibition of cyclooxygenase-2 attenuates antibody responses against vaccinia infection. Vaccine 2010, 28:1363-1372.
13. Naik A.A., Xie C., Zuscik M.J., Kingsley P., Schwarz E.M., Awad H., Guldberg R., Drissi H., Puzas J.E., Boyce B., Zhang X., O'Keefe R.J. Reduced COX-2 expression in aged mice is associated with impaired fracture healing. J. Bone Miner. Res. 2009, 24:251-264.
14. + B cells: memory B cells or "memory" B cells?. J. Immunol. 2007, 179:13-19.
15. Blaeser A., McGlauchlen K., Vogel L.A. Aged B lymphocytes retain their ability to express surface markers but are dysfunctional in their proliferative capability during early activation events. Immun. Ageing 2008, 5:15.
16. Dailey R.W., Eun S.Y., Russell C.E., Vogel L.A. B cells of aged mice show decreased expansion in response to antigen, but are normal in effector function. Cell. Immunol. 2001, 214:99-109.
17. Chen W.H., Kozlovsky B.F., Effros R.B., Grubeck-Loebenstein B., Edelman R., Sztein M.B. Vaccination in the elderly: an immunological perspective. Trends Immunol. 2009, 30:351-359.
18. Siegrist C.A., Aspinall R. B-cell responses to vaccination at the extremes of age. Nat. Rev. Immunol. 2009, 9:185-194.
19. Kishimoto T. Interleukin-6: discovery of a pleiotropic cytokine. Arthritis Res. Ther. 2006, 8:S2.
20. Nishimoto N., Kishimoto T. Interleukin 6: from bench to bedside. Nat. Clin. Pract. Rheumatol. 2006, 2:619-626.
21. Saraiva M., O'Garra A. The regulation of IL-10 production by immune cells. Nat. Rev. Immunol. 2010, 10:170-181.
22. Couper K.N., Blount D.G., Riley E.M. IL-10: the master regulator of immunity to infection. J. Immunol. 2008, 180:5771-5777.
23. Sansoni P., Vescovini R., Fagnoni F., Biasini C., Zanni F., Zanlari L., Telera A., Lucchini G., Passeri G., Monti D., Franceschi C., Passeri M. The immune system in extreme longevity. Exp. Gerontol. 2008, 43:61-65.
24. Hakim F.T., Gress R.E. Immunosenescence: deficits in adaptive immunity in the elderly. Tissue Antigens 2007, 70:179-189.
25. Hayek M.G., Mura C., Wu D., Beharka A.A., Han S.N., Paulson K.E., Hwang D., Meydani S.N. Enhanced expression of inducible cyclooxygenase with age in murine macrophages. J. Immunol. 1997, 159:2445-2451.
26. Ulrich C.M., Bigler J., Potter J.D. Non-steroidal anti-inflammatory drugs for cancer prevention: promise Perils and pharmacogenetics. Nat. Rev. Cancer 2006, 6:130-140.
27. Dai C., Stafford R.S., Alexander G.C. National trends in cyclooxygenase-2 inhibitor use since market release: nonselective diffusion of a selectively cost-effective innovation. Arch. Intern. Med. 2005, 165:171-177.
28. Howard W.A., Gibson K.L., Dunn-Walters D.K. Antibody quality in old age. Rejuvenation Res. 2006, 9:117-125.
29. Frasca D., Landin A.M., Lechner S.C., Ryan J.G., Schwartz R., Riley R.L., Blomberg B.B. Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells. J. Immunol. 2008, 180:5283-5290.
30. Guy B. Strategies to improve the effect of vaccination in the elderly: the vaccine producer's perspective. J. Comp. Pathol. 2010, 142:S133-S137.
31. Weinberger B., Herndler-Brandstetter D., Schwanninger A., Weiskopf D., Grubeck-Loebenstein B. Biology of immune responses to vaccines in elderly persons. Clin. Infect. Dis. 2008, 46:1078-1084.
32. Bernasconi N.L., Traggiai E., Lanzavecchia A. Maintenance of serological memory by polyclonal activation of human memory B cells. Science 2002, 298:2199-2202.
33. Bernard M.P., Phipps R.P. CpG oligodeoxynucleotides induce cyclooxygenase-2 in human B lymphocytes: implications for adjuvant activity and antibody production. Clin. Immunol. 2007, 125:138-148.
34. Maeda K., Mehta H., Drevets D.A., Coggeshall K.M. IL-6 increases B cell IgG production in a feed-forward pro-inflammatory mechanism to skew hematopoiesis and elevate myeloid production. Blood 2010, 115:4699-4706.
35. Ishihara K., Hirano T. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev. 2002, 13:357-368.
36. Mauri C., Gray D., Mushtaq N., Londei M. Prevention of arthritis by interleukin 10-producing B cells. J. Exp. Med. 2003, 197:489-501.
37. Shinomiya S., Naraba H., Ueno A., Utsunomiya I., Maruyama T., Ohuchida S., Ushikubi F., Yuki K., Narumiya S., Sugimoto Y., Ichikawa A., Oh-ishi S. Regulation of TNFalpha and interleukin-10 production by prostaglandins I(2) and E(2): studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists. Biochem. Pharmacol. 2001, 61:1153-1160.
38. -) B cell population is increased in the peripheral blood of elderly people. Mech. Ageing Dev. 2009, 130:681-690.
39. + B cells are crucial in secondary immune response by producing high affinity IgM. Clin. Immunol. 2003, 108:128-137.
40. Lazuardi L., Jenewein B., Wolf A.M., Pfister G., Tzankov A., Grubeck-Loebenstein B. Age-related loss of naïve T cells and dysregulation of T-cell/B-cell interactions in human lymph nodes. Immunology 2005, 144:37-43.