Effect of iontophoresis and permeation enhancers on the permeation of an acyclovir gel

Current Drug Delivery

Volumn 7, Issue 4, 2010, Pages 329-333

  Vaghani, Subhash S ^a   Gurjar, Mitesh ^b   Singh, Sachin ^b   Sureja, Sunil ^b   Koradia, Shailesh ^a   Jivani, N P ^a   Patel, M M ^c  

^a Smt R B Patel Mahila Pharmacy College   (India)

^b PES COLLEGE OF PHARMACY   (India)

^c Kalol Institute of Pharmacy   (India)

Author keywords

Acyclovir; Gel; Iontophoresis; Menthol; N methyl 2 pyrrolidone; Permeation enhancers; Polyethylene glycol

Indexed keywords

1 METHYL 2 PYRROLIDINONE; ACICLOVIR; CARBOPOL 940; HYDROXYPROPYLMETHYLCELLULOSE; MACROGOL 400; MENTHOL; PENETRATION ENHANCING AGENT; TRIETHANOLAMINE;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; DRUG FORMULATION; DRUG PENETRATION; GEL; IONTOPHORESIS; NONHUMAN; PRIORITY JOURNAL; SKIN PENETRATION; STEADY STATE; SWINE;

ACRYLIC RESINS; ACYCLOVIR; ADJUVANTS, PHARMACEUTIC; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GELS; IONTOPHORESIS; MENTHOL; METHYLCELLULOSE; POLYETHYLENE GLYCOLS; PYRROLIDINONES; SKIN ABSORPTION; SWINE;

EID: 77958456864     PISSN: 15672018     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720110793360603     Document Type: Article

References (19)

1. Stagni, G.; Ali, M.E.; Weng, D. Pharmacokinetics of acyclovir in rabbit skin after IV-bolus, ointment, and iontophoretic administrations. Int. J. Pharm., 2004, 274, 201-211.
2. Zhang, I.; Schung, K.K.; Edwards, D.A. Hydrogels with enhanced mass transfer for transdermal drug delivery. J. Pharm. Sci., 1996, 85, 1312-1316.
3. Morrel; Spruance, S.L.; Goldberg, D.I. Topical iontophoretic administration of acyclovir for the episodic treatment of herpes labialis: A randomized, double-Blind, placebo-Controlled, clinicinitiated trial. Clin. Infect. Dis., 2006, 43, 460-467.
4. Sebastiani, P.; Nicoli, S.; Santi, P. Effect of lactic acid and iontophoresis on drug permeation across rabbit ear skin. Int. J. Pharm., 2005, 292, 119-126.
5. Font, A.F.; Fernandez, C.B.; Merino, V.; Castellano, A.L. Combination strategies for enhancing transdermal absorption of sumatriptan through skin. Int. J. Pharm., 2006, 323, 125-130.
6. Panchagula, R.; Bokalial, R.; Sharma, P.; Khandavilli, S. Transdermal delivery of naloxone: skin permeation, pharmacokinetic, irritancy and stability studies. Int. J. Pharm., 2005, 293, 213-223.
7. Kotwal, V.; Bhise, K.; Thube, R. Enhancement of iontophoretic transport of diphenhydramine hydrochloride thermosensitive gel by optimization of pH, polymer concentration, electrode design, and pulse rate. AAPS Pharm. Sci. Tech., 2007, 8, E1-E6.
8. Tanna, S.; Sahota, T.; Clark, J.; Taylor, M.J. Covalent coupling of concanavalin to a carbopol 934P and 941P carrier in glucosesensitive gels for delivery of insulin. J. Pharm. Pharmacol., 2002, 54, 1461-1469.
9. Tas, C.; Ozkan, Y.; Savaser, A.; Baykara, T. In vitro and ex vivo permeation studies of chlorpheniramine maleate gels prepared by carbomer derivatives. Drug. Dev. Ind. Pharm., 2004, 30, 637-647
10. Rowe, R.C.; Sheskey, P.J.; Owen SC. Handbook of Pharmaceutical Excipients. 5th ed., PhP; London, 2006.
11. Bhatia, K.S.; Singh, J. Percutaneous absorption of LHRH through porcine skin: effect of N-methyl 2-pyrrolidone and isopropyl myristate. Drug. Dev. Ind. Pharm., 1997, 23, 1111-1114.
12. Alberti, I.; Kalia, Y.N.; Naik, A. In vivo assessment of enhancement topical delivery of terbinafine to human stratum corneum. J. Control Release, 2001, 71, 319-327.
13. Shishu; Aggrawal, N. Preparation of hydrogels of griseofulvin for dermal application. Int. J. Pharm., 2006, 326, 20-24.
14. Kikwai, L.; Babu, R.J.; Prado, R.; Kolot, A.; Armstrong, C.A.; Ansel, J.C.; Singh, M. In vitro and vivo evaluation of topical formulations of spantide II. AAPS. Pharm. Sci. Tech., 2005, 6, E565-E572.
15. Meidan, V.M.; Khalili, M.A.; Michniak, B.B. Enhanced iontophoretic delivery of buspirone hydrochloride across human skin using chemical enhancers. Int. J. Pharm., 2003, 264, 73-83.
16. Al-Khalili, M.; Meidan, V.M.; Michniak, B.B. Iontophoretic transdermal delivery of buspirone hydrochloride in hairless mouse skin. AAPS Pharm. Sci., 2003, 5, 1-11.
17. Tiwari, S.B.; Udupa, N. Investigation into the potential of iontophoresis facilitated delivery of ketorolac. Int. J. Pharm., 2003, 260, 93-103.
18. Liu, H.; Li, S.; Wang, Y.; Yao, H.; Zhang, Y. Effect of vehicles and enhancers on the topical delivery of cyclosporin A. Int. J. Pharm., 2006, 311,182-186.
19. Barry, B.W. mode of action of penetration enhancers in human skin. J. Control Release, 1987, 6, 85-97.