Enhancement of iontophoretic transport of diphenhydramine hydrochloride thermosensitive gel by optimization of pH, polymer concentration, electrode design, and pulse rate

AAPS PharmSciTech

Volumn 8, Issue 4, 2007, Pages

  Kotwal, Vikram ^a   Bhise, Kiran ^a   Thube, Rahul ^a  

^a Allana College of Pharmacy   (India)

Author keywords

Conductance; Permeation; Pig skin; Pulsed current; Thermosensitive gel; Viscosity

Indexed keywords

DIPHENHYDRAMINE; POLOXAMER; SILVER; SILVER CHLORIDE; CHOLINERGIC RECEPTOR BLOCKING AGENT; LUTROL F 127; POLYETHYLENE DERIVATIVE; POLYPROPYLENE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CALCULATION; CONCENTRATION (PARAMETERS); CONDUCTOMETRY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG TRANSPORT; GEL; HEAT SENSITIVITY; IONTOPHORESIS; NONHUMAN; PASSIVE TRANSPORT; PATIENT COMPLIANCE; PH MEASUREMENT; PROCESS OPTIMIZATION; PULSE RATE; SKIN CONDUCTANCE; SKIN ELECTRODE; SKIN PERMEABILITY; SURFACE PROPERTY; SWINE; TEMPERATURE MEASUREMENT; VISCOSITY; ANIMAL; CHEMISTRY; DIFFUSION CHAMBER; ELECTRODE; EQUIPMENT DESIGN; FEASIBILITY STUDY; INSTRUMENTATION; INTRADERMAL DRUG ADMINISTRATION; METABOLISM; METHODOLOGY; PERMEABILITY; PH; PHARMACEUTICS; SKIN; SKIN ABSORPTION; TEMPERATURE; TIME;

ADMINISTRATION, CUTANEOUS; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHOLINERGIC ANTAGONISTS; DIFFUSION CHAMBERS, CULTURE; DIPHENHYDRAMINE; DRUG COMPOUNDING; ELECTRODES; EQUIPMENT DESIGN; FEASIBILITY STUDIES; GELS; HYDROGEN-ION CONCENTRATION; IONTOPHORESIS; PERMEABILITY; POLYETHYLENES; POLYPROPYLENES; SKIN; SKIN ABSORPTION; SWINE; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; TIME FACTORS; VISCOSITY;

EID: 38549148812     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt0804097     Document Type: Article

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