The pseudo signal peptide of the corticotropin-releasing factor receptor type 2a decreases receptor expression and prevents Gi-mediated inhibition of adenylyl cyclase activity

Journal of Biological Chemistry

Volumn 285, Issue 43, 2010, Pages 32878-32887

  Schulz, Katharina ^a   Rutz, Claudia ^a   Westendorf, Carolin ^a   Ridelis, Ingrid ^a   Vogelbein, Susanne ^a   Furkert, Jens ^a   Schmidt, Antje ^b   Wiesner, Burkhard ^a   Schülein, Ralf ^a  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLYL CYCLASE; CELL SURFACE RECEPTORS; CORTICOTROPIN-RELEASING FACTORS; ENDOPLASMIC RETICULUM MEMBRANES; G PROTEIN COUPLED RECEPTORS; N-TERMINALS; NASCENT CHAINS; PSEUDO-SIGNAL; RECEPTOR DOMAINS; RECEPTOR EXPRESSION; SIGNAL PEPTIDE;

CELL MEMBRANES; GENE ENCODING; PEPTIDES;

SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; CORTICOTROPIN RELEASING FACTOR RECEPTOR 2A; HORMONE RECEPTOR; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; SIGNAL PEPTIDE; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL SURFACE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ANIMALS; CELL LINE; GENE EXPRESSION REGULATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HUMANS; PROTEIN SORTING SIGNALS; RATS; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; SIGNAL TRANSDUCTION;

EID: 77958453912     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.129627     Document Type: Article

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