The silent war against CMV in CLL

Blood

Volumn 116, Issue 16, 2010, Pages 2869-2870

  Akbar, Arne N ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELL POPULATION; CELL SPECIFICITY; CELL SURVIVAL; CELLULAR IMMUNITY; CHRONIC LYMPHATIC LEUKEMIA; COHORT ANALYSIS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; HUMAN; LEUKEMIA CELL; MEMORY T LYMPHOCYTE; MIXED INFECTION; NONHUMAN; NOTE; PRIORITY JOURNAL; PUBLICATION; SURVIVAL RATE; T LYMPHOCYTE; VIREMIA;

EID: 77958189713     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-07-293431     Document Type: Note

References (9)

1. Pourgheysari B, Bruton R, Parry H, et al. Levels of cytomegalovirus- specific CD4+ T cells are markedly expanded in patients with B-cell chronic lymphocytic leukemia and determine the total CD4+ T cell repertoire. Blood. 2010;116(16):2968-2974.
2. Koch S, Larbi A, Ozcelik D, et al. Cytomegalovirus infection: a driving force in human T cell immunosenescence. Ann N Y Acad Sci. 2007;1114:23-35. (Pubitemid 350070409)
3. Wikby A, Ferguson F, Forsey R, et al. An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans. J Gerontol A Biol Sci Med Sci. 2005;60(5):556-565.
4. Stowe RP, Kozlova EV, Yetman DL, et al. Chronic herpesvirus reactivation occurs in aging. Exp Gerontol. 2007;42(2):563-570.
5. Mackus WJ, Frakking FN, Grummels A, et al. Expansion of CMV-specific CD8+CD45RA+. Blood. 2003;102(3):1057-1063.
6. Akbar AN, Fletcher JM. Memory T cell homeostasis and senescence during aging. Curr Opin Immunol. 2005;17(5):480-485.
7. Messaoudi I, Lemaoult J, Guevara-Patino JA, Metzner BM, Nikolich-Zugich J. Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense. J Exp Med. 2004;200(10):1347-1358. (Pubitemid 39552575)
8. Khan N, Hislop A, Gudgeon N, et al. Herpesvirus-specific CD8 T cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection. J Immunol. 2004;173(12):7481-7489.
9. Levin MJ, Smith JG, Kaufhold RM, et al. Decline in varicella-zoster virus (VZV)-specific cell-mediated immunity with increasing age and boosting with a high-dose VZV vaccine. J Infect Dis. 2003;188(9):1336-1344.