Dendritic cells devoid of IL-10 induce protective immunity against the protozoan parasite Trypanosoma cruzi

Vaccine

Volumn 28, Issue 46, 2010, Pages 7407-7413

  Alba Soto, Catalina D ^a   Solana, Maria Elisa ^a   Poncini, Carolina V ^a   Pino Martinez, Agustina M ^a   Tekiel, Valeria ^b   González Cappa, Stella Maris ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b INSTITUTO DE INVESTIGACIONES BIOTECNOLÓGICAS   (Argentina)

Author keywords

Adoptive transfer; Dendritic cells; IL 10; IL 10 deficient mice; Mouse model; Trypanosoma cruzi; Vaccine

Indexed keywords

DENDRITIC CELL VACCINE; INTERLEUKIN 10;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; FLOW CYTOMETRY; IMMUNITY; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; INFECTION PREVENTION; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS; TRYPOMASTIGOTE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, PROTOZOAN; CHAGAS DISEASE; DENDRITIC CELLS; FEMALE; INTERFERON-GAMMA; INTERLEUKIN-10; LYMPHOCYTE CULTURE TEST, MIXED; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; TRYPANOSOMA CRUZI;

EID: 77958184678     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2010.08.105     Document Type: Article

References (37)

1. Tarleton R.L. New approaches in vaccine development for parasitic infections. Cell Microbiol 2005, 7(10):1379-1386.
2. Manickasingham S.P., Edwards A.D., Schulz O., Reis e Sousa C. The ability of murine dendritic cell subsets to direct T helper cell differentiation is dependent on microbial signals. Eur J Immunol 2003, 33(January (1)):101-107.
3. Boonstra A., Asselin-Paturel C., Gilliet M., Crain C., Trinchieri G., Liu Y.J., et al. Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation. J Exp Med 2003, 197(January (1)):101-109.
4. Carreno B.M., Collins M. The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annu Rev Immunol 2002, 20:29-53.
5. Kaliński P., Hilkens C.M., Wierenga E.A., Kapsenberg M.L. T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol Today 1999, 20(December (12)):561-567.
6. Fajardo-Moser M., Berzel S., Moll H. Mechanisms of dendritic cell-based vaccination against infection. Int J Med Microbiol 2008, 298(January (1-2)):11-20.
7. Schuler G., Schuler-Thurner B., Steinman R.M. The use of dendritic cells in cancer immunotherapy. Curr Opin Immunol 2003, 15(April (2)):138-147.
8. Steinman R.M., Pope M. Exploiting dendritic cells to improve vaccine efficacy. J Clin Invest 2002, 109(June (12)):1519-1526.
9. Abrahamsohn I.A., Coffman R.L. Cytokine and nitric oxide regulation of the immunosuppression in Trypanosoma cruzi infection. J Immunol 1995, 155(October (8)):3955-3963.
10. Kierszenbaum F., de Diego J.L., Fresno M., Sztein M.B. Inhibitory effects of the Trypanosoma cruzi membrane glycoprotein AGC10 on the expression of IL-2 receptor chains and secretion of cytokines by subpopulations of activated human T lymphocytes. Eur J Immunol 1999, 29(May (5)):1684-1691.
11. Tarleton R.L. Regulation of immunity in Trypanosoma cruzi infection. Exp Parasitol 1991, 73(July (1)):106-109.
12. Alba Soto C.D., Mirkin G.A., Solana M.E., González Cappa S.M. Trypanosoma cruzi infection modulates in vivo expression of major histocompatibility complex class II molecules on antigen-presenting cells and T-cell stimulatory activity of dendritic cells in a strain-dependent manner. Infect Immun 2003, 71(March (3)):1194-1199.
13. Poncini C.V., Alba Soto C.D., Batalla E., Solana M.E., González Cappa S.M. Trypanosoma cruzi induces regulatory dendritic cells in vitro. Infect Immun 2008, 76(June (6)):2633-2641.
14. Poncini C.V., Giménez G., Pontillo C.A., Alba Soto C.D., Isola E.L.D., Piazzón I., et al. Central role of extracellular signal-regulated kinase and Toll-like receptor 4 in IL-10 production in regulatory dendritic cells induced by Trypanosoma cruzi. Mol Immunol 2010, 47(July (11-12)):1981-1988.
15. Perona-Wright G., Jenkins S.J., Crawford A., Gray D., Pearce E.J., MacDonald A.S. Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo. Eur J Immunol 2006, 36(September (9)):2367-2375.
16. Demangel C., Bertolino P., Britton W.J. Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production. Eur J Immunol 2002, 32(April (4)):994-1002.
17. Corinti S., Albanesi C., la Sala A., Pastore S., Girolomoni G. Regulatory activity of autocrine IL-10 on dendritic cell functions. J Immunol 2001, 166(April (7)):4312-4318.
18. Inaba K., Inaba M., Romani N., Aya H., Deguchi M., Ikehara S., et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992, 176(December (6)):1693-1702.
19. Kleindienst P., Brocker T. Endogenous dendritic cells are required for amplification of T cell responses induced by dendritic cell vaccines in vivo. J Immunol 2003, 170(March (6)):2817-2823.
20. Van Overtvelt L., Vanderheyde N., Verhasselt V., Ismaili J., De Vos L., Goldman M., et al. Trypanosoma cruzi infects human dendritic cells and prevents their maturation: inhibition of cytokines, HLA-DR, and costimulatory molecules. Infect Immun 1999, 67(August (8)):4033-4040.
21. Brodskyn C., Patricio J., Oliveira R., Lobo L., Arnholdt A., Mendonça-Previato L., et al. Glycoinositolphospholipids from Trypanosoma cruzi interfere with macrophages and dendritic cell responses. Infect Immun 2002, 70(July (7)):3736-3743.
22. Chaussabel D., Pajak B., Vercruysse V., Bisseyé C., Garzé V., Habib M., et al. Alteration of migration and maturation of dendritic cells and T-cell depletion in the course of experimental Trypanosoma cruzi infection. Lab Invest 2003, 83(September (9)):1373-1382.
23. Vray B., Camby I., Vercruysse V., Mijatovic T., Bovin N.V., Ricciardi-Castagnoli P., et al. Up-regulation of galectin-3 and its ligands by Trypanosoma cruzi infection with modulation of adhesion and migration of murine dendritic cells. Glycobiology 2004, 14(July (7)):647-657.
24. Chen Y.X., Man K., Ling G.S., Chen Y., Sun B.S., Cheng Q., et al. A crucial role for dendritic cell (DC) IL-10 in inhibiting successful DC-based immunotherapy: superior antitumor immunity against hepatocellular carcinoma evoked by DC devoid of IL-10. J Immunol 2007, 179(November (9)):6009-6015.
25. Igietseme J.U., Ananaba G.A., Bolier J., Bowers S., Moore T., Belay T., et al. Suppression of endogenous IL-10 gene expression in dendritic cells enhances antigen presentation for specific Th1 induction: potential for cellular vaccine development. J Immunol 2000, 164(April (8)):4212-4219.
26. He Q., Moore T.T., Eko F.O., Lyn D., Ananaba G.A., Martin A., et al. Molecular basis for the potency of IL-10-deficient dendritic cells as a highly efficient APC system for activating Th1 response. J Immunol 2005, 174(April (8)):4860-4869.
27. Anderson C.F., Oukka M., Kuchroo V.J., Sacks D. CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J Exp Med 2007, 204(February (2)):285-297.
28. Jankovic D., Kullberg M.C., Feng C.G., Goldszmid R.S., Collazo C.M., Wilson M., et al. Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J Exp Med 2007, 204(February (2)):273-283.
29. Belkaid Y., Piccirillo C.A., Mendez S., Shevach E.M., Sacks D.L. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 2002, 420(December (6915)):502-507.
30. Gazzinelli R.T., Wysocka M., Hieny S., Scharton-Kersten T., Cheever A., Kühn R., et al. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. J Immunol 1996, 157(July (2)):798-805.
31. Couper K.N., Blount D.G., Riley E.M. IL-10: the master regulator of immunity to infection. J Immunol 2008, 180(May (9)):5771-5777.
32. Maroof A., Beattie L., Kirby A., Coles M., Kaye P.M. Dendritic cells matured by inflammation induce CD86-dependent priming of naive CD8+ T cells in the absence of their cognate peptide antigen. J Immunol 2009, 183(December (11)):7095-7103.
33. Li C., Corraliza I., Langhorne J. A defect in interleukin-10 leads to enhanced malarial disease in Plasmodium chabaudi chabaudi infection in mice. Infect Immun 1999, 67(September (9)):4435-4442.
34. Hölscher C., Mohrs M., Dai W.J., Köhler G., Ryffel B., Schaub G.A., et al. Tumor necrosis factor alpha-mediated toxic shock in Trypanosoma cruzi-infected interleukin 10-deficient mice. Infect Immun 2000, 68(July (7)):4075-4083.
35. Hunter C.A., Ellis-Neyes L.A., Slifer T., Kanaly S., Grünig G., Fort M., et al. IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi. J Immunol 1997, 158(April (7)):3311-3316.
36. Planelles L., Thomas M.C., Marañón C., Morell M., López M.C. Differential CD86 CD40 co-stimulatory molecules and cytokine expression pattern induced by Trypanosoma cruzi in APCs from resistant or susceptible mice. Clin Exp Immunol 2003, 131(January (1)):41-47.
37. Moore K.W., de Waal Malefyt R., Coffman R.L., O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001, 19:683-765.