Short communication: Inhibition of X4-tropic HIV type 1 replication by knockdown of the cellular protein LEREPO4

AIDS Research and Human Retroviruses

Volumn 26, Issue 10, 2010, Pages 1155-1161

  Capalbo, Gianni ^a   Müller Kuller, Thea ^a   Dietrich, Ursula ^b   Hoelzer, Dieter ^a   Ottmann, Oliver G ^a   Scheuring, Urban J ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN P24; BETA GALACTOSIDASE; CELL PROTEIN; ERYTHROPOIETIN; PROTEIN LEREPO 4; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CHEMOKINE RECEPTOR CCR5; HOST FACTOR; ZINC FINGER PROTEIN;

ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IN VITRO STUDY; LEUKEMIA CELL LINE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE; UPREGULATION; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS TRANSCRIPTION; GENETICS; HOST PATHOGEN INTERACTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METABOLISM; PHYSIOLOGY; VIROLOGY;

GENE KNOCKDOWN TECHNIQUES; HIV INFECTIONS; HIV-1; HOST-DERIVED CELLULAR FACTORS; HOST-PATHOGEN INTERACTIONS; HUMANS; JURKAT CELLS; RECEPTORS, CCR5; RNA, SMALL INTERFERING; UP-REGULATION; VIRUS REPLICATION; ZINC FINGERS;

EID: 77958177980     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.2010.0041     Document Type: Article

References (32)

1. Freed EO: HIV-1 and the host cell: An intimate association. Trends Microbiol 2004;12:170-177.
2. Peterlin BM and Trono D: Hide, shield and strike back: How HIV-infected cells avoid immune eradication. Nat Rev Immunol 2003;3:97-107.
3. Scheuring UJ, Corbeil J, Mosier DE, and Theofilopoulos AN: Early modification of host cell gene expression induced by HIV-1. AIDS 1998;12:563-570.
4. Geiss GK, Bumgarner RE, An MC, et al.: Large-scale monitoring of host cell gene expression during HIV-1 infection using cDNA microarrays. Virology 2000;266:8-16.
5. Yin J, Chen MF, and Finkel TH: Differential gene expression during HIV-1 infection analyzed by suppression subtractive hybridization. AIDS 2004;18:587-596.
6. Krishnan V and Zeichner SL: Host cell gene expression during human immunodeficiency virus type 1 latency and reactivation and effects of targeting genes that are differentially expressed in viral latency. J Virol 2004;78:9458-9473.
7. Bosinger SE, Hosiawa KA, Cameron MJ, et al.: Gene expression profiling of host response in models of acute HIV infection. J Immunol 2004;173:6858-6863.
8. Cicala C, Arthos J, Selig SM, et al.: HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication. Proc Natl Acad Sci USA 2002;99:9380-9385.
9. de la Fuente C, Santiago F, Deng L, et al.: Gene expression profile of HIV-1 Tat expressing cells: A close interplay between proliferative and differentiation signals. BMC Biochem 2002;3:14.
10. Janket ML, Manickam P, Majumder B, et al.: Differential regulation of host cellular genes by HIV-1 viral protein R (Vpr): cDNA microarray analysis using isogenic virus. Biochem Biophys Res Commun 2004;314:1126-1132.
11. Joseph AM, Kumar M, and Mitra D: Nef: "Necessary and enforcing factor" in HIV infection. Curr HIV Res 2005;3:87-94.
12. Kolegraff K, Bostik P, and Ansari AA: Characterization and role of lentivirus-associated host proteins. Exp Biol Med (Maywood) 2006;231:252-263.
13. Brass AL, Dykxhoorn DM, Benita Y, et al.: Identification of host proteins required for HIV infection through a functional genomic screen. Science 2008;319:921-926.
14. Kameoka M, Kameoka Y, Utachee P, et al.: RNA interference directed against Axin1 upregulates human immunodeficiency virus type 1 gene expression by activating the Wnt signaling pathway in HeLa-derived J111 cells. AIDS Res Hum Retroviruses 2009;25:1005-1011.
15. Goff SP: Genetic control of retrovirus susceptibility in mammalian cells. Annu Rev Genet 2004;38:61-85.
16. Komano J, Futahashi Y, Urano E, et al.: The interaction of HIV-1 with the host factors. Jpn J Infect Dis 2005;58:125-130.
17. Wahl SM, Greenwell-Wild T, and Vazquez N: HIV accomplices and adversaries in macrophage infection. J Leukoc Biol 2006;80:973-983.
18. Gregory RC, Lord KA, Panek LB, Gaines P, Dillon SB, and Wojchowski DM: Subtraction cloning and initial characterization of novel epo-immediate response genes. Cytokine 2000;12:845-857.
19. Strausberg RL, Feingold EA, Grouse LH, et al.: Generation and initial analysis of more than 15, 000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci USA 2002;99:16899-16903.
20. Ishikawa K, Azuma S, Ikawa S, Semba K, and Inoue J: Identification of DRG family regulatory proteins (DFRPs): Specific regulation of DRG1 and DRG2. Genes Cells 2005;10:139-150.
21. Charneau P, Alizon M, and Clavel F: A second origin of DNA plus-strand synthesis is required for optimal human immunodeficiency virus replication. J Virol 1992;66:2814-2820.
22. Scheuring UJ, Pfeifer H, Wassmann B, et al.: Early minimal residual disease (MRD) analysis during treatment of Philadelphia chromosome/Bcr-Abl- positive acute lymphoblastic leukemia with the Abl-tyrosine kinase inhibitor imatinib (STI571). Blood 2003;101:85-90.
23. Klein SA, Karsten S, Ruster B, et al.: Comparison of TaqMan real-time PCR and p24 Elisa for quantification of in vitro HIV-1 replication. J Virol Methods 2003;107:169-175.
24. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, and Tuschl T: Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001;411:494-498.
25. Elbashir SM, Lendeckel W, and Tuschl T: RNA interference is mediated by 21-and 22-nucleotide RNAs. Genes Dev 2001;15:188-200.
26. Novina CD, Murray MF, Dykxhoorn DM, et al.: siRNA-directed inhibition of HIV-1 infection. Nat Med 2002;8:681-686.
27. Leipe DD, Wolf YI, Koonin EV, and Aravind L: Classification and evolution of P-loop GTPases and related ATPases. J Mol Biol 2002;317:41-72.
28. Mahajan MA, Park ST, and Sun XH: Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins. Oncogene 1996;12:2343-2350.
29. Fortin JF, Barat C, Beausejour Y, Barbeau B, and Tremblay MJ: Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-kappaB, and AP-1 induction. J Biol Chem. 2004;279:39520-39531.
30. Lesner A, Li Y, Nitkiewicz J, et al.: A soluble factor secreted by an HIV-1-resistant cell line blocks transcription through inactivating the DNA-binding capacity of the NF-kappa B p65/p50 dimer. J Immunol 2005;175:2548-2554.
31. Su G, Min W, and Taylor EW: An HIV-1 encoded peptide mimics the DNA binding loop of NF-kappaB and binds thioredoxin with high affinity. Mutat Res 2005;579:133-148.
32. Varin A, Decrion AZ, Sabbah E, et al.: Synthetic Vpr protein activates activator protein-1, c-Jun. N-terminal kinase, and NF-kappaB and stimulates HIV-1 transcription in promonocytic cells and primary macrophages. J Biol Chem 2005;280:42557-42567.