Sugammadex rapidly reverses moderate rocuronium- or vecuronium-induced neuromuscular block during sevoflurane anaesthesia: A dose - Response relationship

British Journal of Anaesthesia

Volumn 105, Issue 5, 2010, Pages 610-619

  Puhringer F K ^a   Gordon, M ^b   Demeyer, I ^c   Sparr, H J ^d   Ingimarsson, J ^e   Klarin, B ^e   Van Duijnhoven, W ^f   Heeringa, M ^f,g  

^a Klinikum am Steinenberg   (Germany)

^b Samodzielny Publiczny Szpital Kliniczny Nr 2   (Poland)

^c OLV HOSPITAL   (Belgium)

^d General Hospital Dornbirn   (Austria)

^e LUND UNIVERSITY HOSPITAL   (Sweden)

^f MSD   (Netherlands)

^g Astellas Pharma Global Development   (Netherlands)

Author keywords

reversal; rocuronium; sevoflurane; sugammadex; vecuronium

Indexed keywords

FENTANYL; NITROUS OXIDE; PIRITRAMIDE; PLACEBO; PROPOFOL; REMIFENTANIL; ROCURONIUM; SEVOFLURANE; SUFENTANIL; SUGAMMADEX; VECURONIUM;

ACCELEROMYOGRAPHY; ADULT; ANESTHESIA INDUCTION; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; FEMALE; HUMAN; HYPOTENSION; INJECTION SITE PAIN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MYOGRAPHY; NAUSEA; NEUROMUSCULAR BLOCKING; OPEN STUDY; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SINGLE DRUG DOSE; STATISTICAL SIGNIFICANCE; SYSTOLIC BLOOD PRESSURE; VOMITING;

EID: 77958173062     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aeq226     Document Type: Article

References (22)

1. Bom A, Bradley M, Cameron K, et al. A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host. Angew Chem Int Ed Engl 2002;41:266-70
2. Epemolu O, Bom A, Hope F, Mason R. Reversal of neuromuscular blockade and simultaneous increase in plasma rocuronium concentration after the intravenous infusion of the novel reversal agent Org 25969. Anesthesiology 2003;99:632-7
3. Zhang M-Q. Drug-specific cyclodextrins: the future of rapid reversal? Drugs Future 2003;28:347-54
4. Suy K, Morias K, Cammu G, et al. Sugammadex, a selective relaxant binding agent, offers effective reversal of moderate rocuronium-or vecuronium-induced neuromuscular block. Anesthesiology 2007;106:283-8
5. Sacan O, White PF, Tufanogullari B, Klein K. Sugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edrophonium-atropine. Anesth Analg 2007;104:569-74
6. Shields M, Giovanelli M, Mirakhur RK, Moppett I, Adams J, Hermens Y. Org 25969 (sugammadex), a selective relaxant binding agent for antagonism of prolonged rocuronium-induced neuromuscular block. Br J Anaesth 2006;96:36-43
7. Sorgenfrei IF, Norrild K, Larsen PB, et al. Reversal of rocuroniuminduced neuromuscular block by the selective relaxant binding agent sugammadex. Anesthesiology 2006;104:667-74
8. de Boer HD, Driessen JJ, Marcus MA, Kerkkamp H, Heeringa M, Klimek M. Reversal of rocuronium-induced (1.2 mg/kg) profound neuromuscular block by sugammadex: a multicenter, dosefinding and safety study. Anesthesiology 2007;107:239-44
9. Groudine SB, Soto R, Lien C, Drover D, Roberts K. A randomized, dose-finding, phase II study of the selective relaxant binding drug, sugammadex, capable of safely reversing profound rocuronium-induced neuromuscular block. Anesth Analg 2007;104:555-62
10. Sparr HJ, Vermeyen KM, Beaufort AM, et al. Early reversal of profound rocuronium-induced neuromuscular blockade by sugammadex in a randomized multicenter study: efficacy, safety and pharmacokinetics. Anesthesiology 2007;106:935-43
11. Vanacker BF, Vermeyen KM, Struys MM, et al. Reversal of rocuronium-induced neuromuscular block with the novel drug sugammadex is equally effective under maintenance anesthesia with propofol or sevoflurane. Anesth Analg 2007;104:563-8
12. Pühringer FK, Rex C, Sielenkämper AW, et al. Reversal of profound, high-dose rocuronium-induced neuromuscular blockade by sugammadex at two different time points: an international, multicenter, randomized, dose-finding, safety assessor-blinded, phase II trial. Anesthesiology 2008;109:188-97
13. Lowry DW, Mirakhur RK, McCarthy GJ, et al. Neuromuscular effects of rocuronium during sevoflurane, isoflurane, and intravenous anesthesia. Anesth Analg 1998;87:936-40
14. Wulf H, Ledowski T, Linstedt U, Proppe D, Sitzlack D. Neuromuscular blocking effects of rocuronium during desflurane, isoflurane, and sevoflurane anaesthesia. Can J Anaesth 1998;45:526-32
15. Xue PS, Liao X, Tong SY, Liu JH, An G, Luo LK. Dose-response and time-course of the effect of rocuronium bromide during sevoflurane anaesthesia. Anaesthesia 1998;53:25-30
16. Viby-Mogensen J, Engbaek J, Eriksson LI, et al. Good clinical research practice (GCRP) in pharmacodynamic studies of neuromuscular blocking agents. Acta Anaesthesiol Scand 1996;40:59-74
17. Epemolu O, Mayer I, Hope F, Scullion P, Desmond P. Liquid chromatography/mass spectrometric bioanalysis of a modified gammacyclodextrin (Org 25969) and rocuronium bromide (Org 9426) in guinea pig plasma and urine: its application to determine the plasma pharmacokinetics of Org 25969. Rapid Commun Mass Spectrom 2002;16:1946-52
18. Gijsenbergh F, Ramael S, Houwing N, van Iersel T. First human exposure of Org 25969, a novel agent to reverse the action of rocuronium bromide. Anesthesiology 2005;103:695-703
19. Rex C, Wagner S, Spies C, et al. Reversal of neuromuscular blockade by sugammadex after continuous infusion of rocuronium in patients randomized to sevoflurane or propofol maintenance anesthesia. Anesthesiology 2009;111:30-5
20. Khuenl-Brady KS, Wattwil M, Vanacker BF, Lora-Tamayo JI, Rietbergen H, Alvarez-Gómez JA. Sugammadex provides faster reversal of vecuronium-induced neuromuscular blockade compared with neostigmine: a multicenter, randomized, controlled trial. Anesth Analg 2010;110:64-73
21. Abrishami A, Ho J, Wong J, Yin L, Chung F. Sugammadex, a selective reversal medication for preventing postoperative residual neuromuscular blockade. Cochrane Database Syst Rev 2009; CD007362
22. Eleveld DJ, Kuizenga K, Proost JH, Wierda JM. A temporary decrease in twitch response during reversal of rocuroniuminduced muscle relaxation with a small dose of sugammadex. Anesth Analg 2007;104:582-4