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Volumn 12, Issue 5, 2010, Pages 358-365

Enteric nervous system in the small intestine: Pathophysiology and clinical implications

Author keywords

Diabetes mellitus; Enteric nervous system; Inflammatory bowel disease; Intestinal secretion; Irritable bowel syndromes; Neurotransmitters; Small intestine

Indexed keywords

ADENOSINE; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE TRIPHOSPHATE; BRADYKININ; CELECOXIB; CILANSETRON; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; GALANIN; GALANIN RECEPTOR 1; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LINACLOTID; LUBIPROSTONE; ME 3412; N [4 [6 [4 (TRIFLUOROMETHYL)PHENYL] 4 PYRIMIDINYLOXY]BENZOTHIAZOL 2 YL]ACETAMIDE; NERVE GROWTH FACTOR; NEUROPEPTIDE Y; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PMG 51749; PROSTAGLANDIN; PRUCALOPRIDE; RAMOSETRON; RENZAPRIDE; ROSE 010; SEROTONIN; SUBSTANCE P; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE;

EID: 77958157016     PISSN: 15228037     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11894-010-0129-9     Document Type: Review
Times cited : (117)

References (56)
  • 2
    • 68549123001 scopus 로고    scopus 로고
    • 5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice
    • 1:CAS:528:DC%2BD1MXpvFOmtb8%3D 10.1523/JNEUROSCI.1145-09.2009 19657021
    • MT Liu YH Kuan J Wang, et al. 2009 5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice J Neurosci 29 9683 9699 1:CAS:528:DC%2BD1MXpvFOmtb8%3D 10.1523/JNEUROSCI.1145-09. 2009 19657021
    • (2009) J Neurosci , vol.29 , pp. 9683-9699
    • Liu, M.T.1    Kuan, Y.H.2    Wang, J.3
  • 3
    • 33748500018 scopus 로고    scopus 로고
    • Advances in ontogeny of the enteric nervous system
    • DOI 10.1111/j.1365-2982.2006.00806.x
    • AJ Burns N Thapar 2006 Advances in ontogeny of the enteric nervous system Neurogastroenterol Motil 18 876 887 1:STN:280:DC%2BD28rjvVKkuw%3D%3D 10.1111/j.1365-2982.2006.00806.x 16961690 (Pubitemid 44358857)
    • (2006) Neurogastroenterology and Motility , vol.18 , Issue.10 , pp. 876-887
    • Burns, A.J.1    Thapar, N.2
  • 4
    • 0038074091 scopus 로고    scopus 로고
    • GDNF availability determines enteric neuron number by controlling precursor proliferation
    • DOI 10.1242/dev.00433
    • S Gianino JR Grider J Cresswell, et al. 2003 GDNF availability determines enteric neuron number by controlling precursor proliferation Development 130 2187 2198 1:CAS:528:DC%2BD3sXkt1Smurg%3D 10.1242/dev.00433 12668632 (Pubitemid 36656714)
    • (2003) Development , vol.130 , Issue.10 , pp. 2187-2198
    • Gianino, S.1    Grider, J.R.2    Cresswell, J.3    Enomoto, H.4    Heuckeroth, R.O.5
  • 5
    • 18044362169 scopus 로고    scopus 로고
    • Enteric neuroblasts require the phosphatidylinositol 3-kinase/Akt/ Forkhead pathway for GDNF-stimulated survival
    • DOI 10.1016/j.mcn.2005.02.005
    • S Srinivasan M Anitha S Mwangi RO Heuckeroth 2005 Enteric neuroblasts require the phosphatidylinositol 3-kinase/Akt/Forkhead pathway for GDNF-stimulated survival Mol Cell Neurosci 29 107 119 1:CAS:528: DC%2BD2MXjslKitrk%3D 10.1016/j.mcn.2005.02.005 15866051 (Pubitemid 40603885)
    • (2005) Molecular and Cellular Neuroscience , vol.29 , Issue.1 , pp. 107-119
    • Srinivasan, S.1    Anitha, M.2    Mwangi, S.3    Heuckeroth, R.O.4
  • 6
    • 0038488561 scopus 로고    scopus 로고
    • Aging of the myenteric plexus: Neuronal loss is specific to cholinergic neurons
    • DOI 10.1016/S1566-0702(03)00072-9
    • RJ Phillips EJ Kieffer TL Powley 2003 Aging of the myenteric plexus: neuronal loss is specific to cholinergic neurons Auton Neurosci 106 69 83 10.1016/S1566-0702(03)00072-9 12878075 (Pubitemid 36870909)
    • (2003) Autonomic Neuroscience: Basic and Clinical , vol.106 , Issue.2 , pp. 69-83
    • Phillips, R.J.1    Kieffer, E.J.2    Powley, T.L.3
  • 7
    • 0031871364 scopus 로고    scopus 로고
    • The effects of age on the overall population and on sub-populations of myenteric neurons in the rat small intestine
    • 10.1046/j.1469-7580.1998.19240479.x 9723975
    • RJ Johnson M Schemann RM Santer T Cowen 1998 The effects of age on the overall population and on sub-populations of myenteric neurons in the rat small intestine J Anat 192 Pt 4 479 488 10.1046/j.1469-7580.1998.19240479.x 9723975
    • (1998) J Anat , vol.192 , Issue.PART 4 , pp. 479-488
    • Johnson, R.J.1    Schemann, M.2    Santer, R.M.3    Cowen, T.4
  • 8
    • 70350573008 scopus 로고    scopus 로고
    • Age-related changes in functional NANC innervation with VIP and substance P in the jejunum of Lewis rats
    • 1:CAS:528:DC%2BD1MXhtlGiu7nP 10.1016/j.autneu.2009.08.004 19734110
    • MS Kasparek J Fatima CW Iqbal, et al. 2009 Age-related changes in functional NANC innervation with VIP and substance P in the jejunum of Lewis rats Auton Neurosci 151 127 134 1:CAS:528:DC%2BD1MXhtlGiu7nP 10.1016/j.autneu.2009.08.004 19734110
    • (2009) Auton Neurosci , vol.151 , pp. 127-134
    • Kasparek, M.S.1    Fatima, J.2    Iqbal, C.W.3
  • 9
    • 9644275537 scopus 로고    scopus 로고
    • Ageing of the enteric nervous system
    • DOI 10.1016/j.mad.2004.09.003, PII S0047637404001824
    • MJ Saffrey 2004 Ageing of the enteric nervous system Mech Ageing Dev 125 899 906 1:CAS:528:DC%2BD2cXhtVant7vE 10.1016/j.mad.2004.09.003 15563936 (Pubitemid 39572627)
    • (2004) Mechanisms of Ageing and Development , vol.125 , Issue.12 SPEC. ISS. , pp. 899-906
    • Saffrey, M.J.1
  • 10
    • 0024379715 scopus 로고
    • Effect of ileal infusion of glycochenodeoxycholic acid on segmental transit, motility, and flow in the human jejunum and ileum
    • 1:CAS:528:DyaL1MXksFShsbw%3D 10.1136/gut.30.5.609 2731753
    • R Penagini RC Spiller JJ Misiewicz PG Frost 1989 Effect of ileal infusion of glycochenodeoxycholic acid on segmental transit, motility, and flow in the human jejunum and ileum Gut 30 609 617 1:CAS:528:DyaL1MXksFShsbw%3D 10.1136/gut.30.5.609 2731753
    • (1989) Gut , vol.30 , pp. 609-617
    • Penagini, R.1    Spiller, R.C.2    Misiewicz, J.J.3    Frost, P.G.4
  • 11
    • 77953352917 scopus 로고    scopus 로고
    • Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system
    • 1:CAS:528:DC%2BC3cXps1emt7s%3D 10.1111/j.1365-2982.2010.01487.x 20236244 e227-818
    • DP Poole C Godfrey F Cattaruzza, et al. 2010 Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system Neurogastroenterol Motil 22 814 825 1:CAS:528:DC%2BC3cXps1emt7s%3D 10.1111/j.1365-2982.2010.01487.x 20236244 e227-818
    • (2010) Neurogastroenterol Motil , vol.22 , pp. 814-825
    • Poole, D.P.1    Godfrey, C.2    Cattaruzza, F.3
  • 12
    • 0037179123 scopus 로고    scopus 로고
    • Distribution of galanin receptor 1 immunoreactivity in the rat stomach and small intestine
    • DOI 10.1002/cne.10311
    • T Pham S Guerrini H Wong, et al. 2002 Distribution of galanin receptor 1 immunoreactivity in the rat stomach and small intestine J Comp Neurol 450 292 302 1:CAS:528:DC%2BD38XmtlyksrY%3D 10.1002/cne.10311 12209857 (Pubitemid 34809999)
    • (2002) Journal of Comparative Neurology , vol.450 , Issue.3 , pp. 292-302
    • Pham, T.1    Guerrini, S.2    Wong, H.3    Reeve Jr., J.4    Sternini, C.5
  • 13
    • 41149105907 scopus 로고    scopus 로고
    • Prolonged elevation of galanin and tachykinin expression in mucosal and myenteric enteric nerves in trinitrobenzene sulphonic acid colitis
    • DOI 10.1111/j.1365-2982.2007.01037.x
    • J Simpson F Sundler DJ Humes, et al. 2008 Prolonged elevation of galanin and tachykinin expression in mucosal and myenteric enteric nerves in trinitrobenzene sulphonic acid colitis Neurogastroenterol Motil 20 392 406 1:CAS:528:DC%2BD1cXltlKgs7g%3D 10.1111/j.1365-2982.2007.01037.x 18208479 (Pubitemid 351441728)
    • (2008) Neurogastroenterology and Motility , vol.20 , Issue.4 , pp. 392-406
    • Simpson, J.1    Sundler, F.2    Humes, D.J.3    Jenkins, D.4    Wakelin, D.5    Scholefield, J.H.6    Spiller, R.C.7
  • 14
    • 0032801960 scopus 로고    scopus 로고
    • Surgically induced leukocytic infiltrates within the rat intestinal muscularis mediate postoperative ileus
    • DOI 10.1053/gast.1999.0029900378
    • JC Kalff TM Carlos WH Schraut, et al. 1999 Surgically induced leukocytic infiltrates within the rat intestinal muscularis mediate postoperative ileus Gastroenterology 117 378 387 1:STN:280:DyaK1MzltVaquw%3D%3D 10.1053/gast.1999. 0029900378 10419919 (Pubitemid 29352946)
    • (1999) Gastroenterology , vol.117 , Issue.2 , pp. 378-387
    • Kalff, J.C.1    Carlos, T.M.2    Schraut, W.H.3    Billiar, T.R.4    Simmons, R.L.5    Bauer, A.J.6
  • 15
    • 0035213538 scopus 로고    scopus 로고
    • Prostanoid production via COX-2 as a causative mechanism of rodent postoperative ileus
    • 1:CAS:528:DC%2BD38Xhs12htQ%3D%3D 10.1053/gast.2001.29605 11729115
    • NT Schwarz JC Kalff A Turler, et al. 2001 Prostanoid production via COX-2 as a causative mechanism of rodent postoperative ileus Gastroenterology 121 1354 1371 1:CAS:528:DC%2BD38Xhs12htQ%3D%3D 10.1053/gast.2001.29605 11729115
    • (2001) Gastroenterology , vol.121 , pp. 1354-1371
    • Schwarz, N.T.1    Kalff, J.C.2    Turler, A.3
  • 16
    • 71949120501 scopus 로고    scopus 로고
    • Clinical trial: The impact of cyclooxygenase inhibitors on gastrointestinal recovery after major surgery-a randomized double blind controlled trial of celecoxib or diclofenac vs. placebo
    • 1:CAS:528:DC%2BD1MXhsFaiurrO 10.1111/j.1365-2036.2009.04126.x 19694636
    • DA Wattchow D De Fontgalland PA Bampton, et al. 2009 Clinical trial: the impact of cyclooxygenase inhibitors on gastrointestinal recovery after major surgery-a randomized double blind controlled trial of celecoxib or diclofenac vs. placebo Aliment Pharmacol Ther 30 987 998 1:CAS:528:DC%2BD1MXhsFaiurrO 10.1111/j.1365-2036.2009.04126.x 19694636
    • (2009) Aliment Pharmacol Ther , vol.30 , pp. 987-998
    • Wattchow, D.A.1    De Fontgalland, D.2    Bampton, P.A.3
  • 17
    • 0037219014 scopus 로고    scopus 로고
    • 1 receptor blockade reverses experimental postoperative ileus in rat colon
    • DOI 10.1016/S0014-2999(02)02766-8, PII S0014299902027668
    • M Kadowaki Y Nagakura K Tokita, et al. 2003 Adenosine A1 receptor blockade reverses experimental postoperative ileus in rat colon Eur J Pharmacol 458 197 200 1:CAS:528:DC%2BD38Xpslaltbo%3D 10.1016/S0014-2999(02)02766-8 12498926 (Pubitemid 36050720)
    • (2003) European Journal of Pharmacology , vol.458 , Issue.1-2 , pp. 197-200
    • Kadowaki, M.1    Nagakura, Y.2    Tokita, K.3    Hanaoka, K.4    Tomoi, M.5
  • 18
    • 56049100674 scopus 로고    scopus 로고
    • Regulation of enteric functions by adenosine: Pathophysiological and pharmacological implications
    • 1:CAS:528:DC%2BD1cXhsVWrs7fF 10.1016/j.pharmthera.2008.08.010 18848843
    • L Antonioli M Fornai R Colucci, et al. 2008 Regulation of enteric functions by adenosine: pathophysiological and pharmacological implications Pharmacol Ther 120 233 253 1:CAS:528:DC%2BD1cXhsVWrs7fF 10.1016/j.pharmthera. 2008.08.010 18848843
    • (2008) Pharmacol Ther , vol.120 , pp. 233-253
    • Antonioli, L.1    Fornai, M.2    Colucci, R.3
  • 20
    • 37249093549 scopus 로고    scopus 로고
    • Interstitial cells of Cajal in diabetic gastroenteropathy
    • DOI 10.1111/j.1365-2982.2007.01056.x
    • T Ordog 2008 Interstitial cells of Cajal in diabetic gastroenteropathy Neurogastroenterol Motil 20 8 18 1:STN:280:DC%2BD1c%2FgvVSitA%3D%3D 10.1111/j.1365-2982.2007.01056.x 18173559 (Pubitemid 350277445)
    • (2008) Neurogastroenterology and Motility , vol.20 , Issue.1 , pp. 8-18
    • Ordog, T.1
  • 21
    • 0032702965 scopus 로고    scopus 로고
    • Neurons undergo apoptosis in animal and cell culture models of diabetes
    • DOI 10.1006/nbdi.1999.0254
    • JW Russell KA Sullivan AJ Windebank, et al. 1999 Neurons undergo apoptosis in animal and cell culture models of diabetes Neurobiol Dis 6 347 363 1:CAS:528:DyaK1MXms1ynsLk%3D 10.1006/nbdi.1999.0254 10527803 (Pubitemid 29496214)
    • (1999) Neurobiology of Disease , vol.6 , Issue.5 , pp. 347-363
    • Russell, J.W.1    Sullivan, K.A.2    Windebank, A.J.3    Herrmann, D.N.4    Feldman, E.L.5
  • 22
    • 2042449726 scopus 로고    scopus 로고
    • In vitro increase in intracellular calcium concentrations induced by low or high extracellular glucose levels in ependymocytes and serotonergic neurons of the rat lower brainstem
    • DOI 10.1210/en.2003-1191
    • R Moriyama H Tsukamura M Kinoshita, et al. 2004 In vitro increase in intracellular calcium concentrations induced by low or high extracellular glucose levels in ependymocytes and serotonergic neurons of the rat lower brainstem Endocrinology 145 2507 2515 1:CAS:528:DC%2BD2cXjsV2jsLc%3D 10.1210/en.2003-1191 14962992 (Pubitemid 38535078)
    • (2004) Endocrinology , vol.145 , Issue.5 , pp. 2507-2515
    • Moriyama, R.1    Tsukamura, H.2    Kinoshita, M.3    Okazaki, H.4    Kato, Y.5    Maeda, K.-I.6
  • 23
    • 41749087817 scopus 로고    scopus 로고
    • Immediate insulin treatment prevents gut motility alterations and loss of nitrergic neurons in the ileum and colon of rats with streptozotocin-induced diabetes
    • 1:CAS:528:DC%2BD1cXks12ht78%3D 10.1016/j.diabres.2007.12.013 18242757
    • F Izbeki T Wittman A Rosztoczy, et al. 2008 Immediate insulin treatment prevents gut motility alterations and loss of nitrergic neurons in the ileum and colon of rats with streptozotocin-induced diabetes Diabetes Res Clin Pract 80 192 198 1:CAS:528:DC%2BD1cXks12ht78%3D 10.1016/j.diabres.2007.12.013 18242757
    • (2008) Diabetes Res Clin Pract , vol.80 , pp. 192-198
    • Izbeki, F.1    Wittman, T.2    Rosztoczy, A.3
  • 24
    • 33749359621 scopus 로고    scopus 로고
    • Glial-Derived Neurotrophic Factor Modulates Enteric Neuronal Survival and Proliferation Through Neuropeptide Y
    • DOI 10.1053/j.gastro.2006.07.019, PII S0016508506016623
    • M Anitha B Chandrasekharan JR Salgado, et al. 2006 Glial-derived neurotrophic factor modulates enteric neuronal survival and proliferation through neuropeptide Y Gastroenterology 131 1164 1178 1:CAS:528: DC%2BD28XhtFyqsr7N 10.1053/j.gastro.2006.07.019 17030186 (Pubitemid 44498695)
    • (2006) Gastroenterology , vol.131 , Issue.4 , pp. 1164-1178
    • Anitha, M.1    Chandrasekharan, B.2    Salgado, J.R.3    Grouzmann, E.4    Mwangi, S.5    Sitaraman, S.V.6    Srinivasan, S.7
  • 25
    • 0035412484 scopus 로고    scopus 로고
    • Diabetes mellitus is associated with a decrease in vasoactive intestinal polypeptide content of gastrointestinal tract of rat
    • DOI 10.1076/apab.109.3.246.11587
    • E Adeghate AS Ponery AK Sharma, et al. 2001 Diabetes mellitus is associated with a decrease in vasoactive intestinal polypeptide content of gastrointestinal tract of rat Arch Physiol Biochem 109 246 251 1:CAS:528:DC%2BD38Xmt12hsLo%3D 10.1076/apab.109.3.246.11587 11880929 (Pubitemid 35216695)
    • (2001) Archives of Physiology and Biochemistry , vol.109 , Issue.3 SPEC ISS. , pp. 246-251
    • Adeghate, E.1    Ponery, A.S.2    Sharma, A.K.3    El-Sharkawy, T.4    Donath, T.5
  • 26
    • 0041510529 scopus 로고    scopus 로고
    • Gastrointestinal dysfunction in Parkinson's disease
    • DOI 10.1016/S1474-4422(03)00307-7
    • RF Pfeiffer 2003 Gastrointestinal dysfunction in Parkinson's disease Lancet Neurol 2 107 116 10.1016/S1474-4422(03)00307-7 12849267 (Pubitemid 37443331)
    • (2003) Lancet Neurology , vol.2 , Issue.2 , pp. 107-116
    • Pfeiffer, R.F.1
  • 27
    • 32544442518 scopus 로고    scopus 로고
    • Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology
    • DOI 10.1016/j.neulet.2005.11.012, PII S0304394005012814
    • H Braak RA de Vos J Bohl K Del Tredici 2006 Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology Neurosci Lett 396 67 72 1:CAS:528:DC%2BD28XhsF2gurc%3D 10.1016/j.neulet.2005.11.012 16330147 (Pubitemid 43233790)
    • (2006) Neuroscience Letters , vol.396 , Issue.1 , pp. 67-72
    • Braak, H.1    De Vos, R.A.I.2    Bohl, J.3    Del Tredici, K.4
  • 28
    • 34548230441 scopus 로고    scopus 로고
    • Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease
    • DOI 10.1016/j.expneurol.2007.05.010, PII S0014488607002087
    • G Anderson AR Noorian G Taylor, et al. 2007 Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease Exp Neurol 207 4 12 1:CAS:528:DC%2BD2sXpvF2lt7k%3D 10.1016/j.expneurol.2007.05.010 17586496 (Pubitemid 47332479)
    • (2007) Experimental Neurology , vol.207 , Issue.1 , pp. 4-12
    • Anderson, G.1    Noorian, A.R.2    Taylor, G.3    Anitha, M.4    Bernhard, D.5    Srinivasan, S.6    Greene, J.G.7
  • 29
    • 67349122370 scopus 로고    scopus 로고
    • Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease
    • 1:CAS:528:DC%2BD1MXnt1eku7k%3D 10.1016/j.expneurol.2009.04.023 19409896
    • JG Greene AR Noorian S Srinivasan 2009 Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease Exp Neurol 218 154 161 1:CAS:528:DC%2BD1MXnt1eku7k%3D 10.1016/j.expneurol.2009. 04.023 19409896
    • (2009) Exp Neurol , vol.218 , pp. 154-161
    • Greene, J.G.1    Noorian, A.R.2    Srinivasan, S.3
  • 30
    • 67650340192 scopus 로고    scopus 로고
    • Pain and inflammatory bowel disease
    • 10.1002/ibd.20848 19130619
    • K Bielefeldt B Davis DG Binion 2009 Pain and inflammatory bowel disease Inflamm Bowel Dis 15 778 788 10.1002/ibd.20848 19130619
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 778-788
    • Bielefeldt, K.1    Davis, B.2    Binion, D.G.3
  • 31
    • 23244457833 scopus 로고    scopus 로고
    • Differential expression of cannabinoid receptors in the human colon: Cannabinoids promote epithelial wound healing
    • 16083701
    • K Wright N Rooney M Feeney, et al. 2005 Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing Gastroenterology 129 437 453 16083701
    • (2005) Gastroenterology , vol.129 , pp. 437-453
    • Wright, K.1    Rooney, N.2    Feeney, M.3
  • 32
    • 33845786505 scopus 로고    scopus 로고
    • 5-HT in the enteric nervous system: Gut function and neuropharmacology
    • DOI 10.1016/j.tins.2006.11.002, PII S0166223606002645
    • PG McLean RA Borman K Lee 2007 5-HT in the enteric nervous system: gut function and neuropharmacology Trends Neurosci 30 9 13 1:CAS:528: DC%2BD2sXhsFWrtQ%3D%3D 10.1016/j.tins.2006.11.002 17126921 (Pubitemid 46001679)
    • (2007) Trends in Neurosciences , vol.30 , Issue.1 , pp. 9-13
    • McLean, P.G.1    Borman, R.A.2    Lee, K.3
  • 33
    • 0038689146 scopus 로고    scopus 로고
    • Adenosine in the spinal cord and periphery: Release and regulation of pain
    • DOI 10.1016/S0301-0082(03)00050-9
    • J Sawynok XJ Liu 2003 Adenosine in the spinal cord and periphery: release and regulation of pain Prog Neurobiol 69 313 340 1:CAS:528:DC%2BD3sXkt1Giu7s%3D 10.1016/S0301-0082(03)00050-9 12787573 (Pubitemid 36645052)
    • (2003) Progress in Neurobiology , vol.69 , Issue.5 , pp. 313-340
    • Sawynok, J.1    Liu, X.J.2
  • 34
    • 33745494099 scopus 로고    scopus 로고
    • Interactive involvement of brain derived neurotrophic factor, nerve growth factor, and calcitonin gene related peptide in colonic hypersensitivity in the rat
    • DOI 10.1136/gut.2005.064063
    • L Delafoy A Gelot D Ardid, et al. 2006 Interactive involvement of brain derived neurotrophic factor, nerve growth factor, and calcitonin gene related peptide in colonic hypersensitivity in the rat Gut 55 940 945 1:CAS:528:DC%2BD28XntF2muro%3D 10.1136/gut.2005.064063 16401692 (Pubitemid 43962604)
    • (2006) Gut , vol.55 , Issue.7 , pp. 940-945
    • Delafoy, L.1    Gelot, A.2    Ardid, D.3    Eschalier, A.4    Bertrand, C.5    Doherty, A.M.6    Diop, L.7
  • 35
    • 70349423402 scopus 로고    scopus 로고
    • Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome
    • 1:CAS:528:DC%2BD1MXht12gtrzK 10.1053/j.gastro.2009.07.005 19596012
    • S Buhner Q Li S Vignali, et al. 2009 Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome Gastroenterology 137 1425 1434 1:CAS:528:DC%2BD1MXht12gtrzK 10.1053/j.gastro.2009.07.005 19596012
    • (2009) Gastroenterology , vol.137 , pp. 1425-1434
    • Buhner, S.1    Li, Q.2    Vignali, S.3
  • 36
    • 65349154634 scopus 로고    scopus 로고
    • Mitochondrial DNA and gastrointestinal motor and sensory functions in health and functional gastrointestinal disorders
    • 1:CAS:528:DC%2BD1MXjtFGrtb4%3D 10.1152/ajpgi.90650.2008 19147801
    • M Camilleri P Carlson AR Zinsmeister, et al. 2009 Mitochondrial DNA and gastrointestinal motor and sensory functions in health and functional gastrointestinal disorders Am J Physiol Gastrointest Liver Physiol 296 G510 G516 1:CAS:528:DC%2BD1MXjtFGrtb4%3D 10.1152/ajpgi.90650.2008 19147801
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296
    • Camilleri, M.1    Carlson, P.2    Zinsmeister, A.R.3
  • 37
    • 69949088285 scopus 로고    scopus 로고
    • Lack of association of tegaserod with adverse cardiovascular outcomes in a matched case-control study
    • 1:CAS:528:DC%2BD1MXhtFGgs7jM 10.1177/1074248409340158 19602672
    • JL Anderson HT May TL Bair, et al. 2009 Lack of association of tegaserod with adverse cardiovascular outcomes in a matched case-control study J Cardiovasc Pharmacol Ther 14 170 175 1:CAS:528:DC%2BD1MXhtFGgs7jM 10.1177/1074248409340158 19602672
    • (2009) J Cardiovasc Pharmacol Ther , vol.14 , pp. 170-175
    • Anderson, J.L.1    May, H.T.2    Bair, T.L.3
  • 40
    • 77951897011 scopus 로고    scopus 로고
    • Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract
    • Bryant AP, Busby RW, Bartolini WP, et al.: Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract. Life Sci 86:760-765
    • Life Sci , vol.86 , pp. 760-765
    • Bryant, A.P.1    Busby, R.W.2    Bartolini, W.P.3
  • 41
    • 77958177283 scopus 로고    scopus 로고
    • GLP-1 playing the role of a gut regulatory compound
    • Epub ahead of print. This randomized, double-blind clinical trial investigates the effect of GLP-1 analogue ROSE-010 in humans, and shows that ROSE-010 is effective in pain relief response in IBS patients affected by pain attacks
    • Hellström PM: GLP-1 playing the role of a gut regulatory compound. Acta Physiol (Oxf) 2010 (Epub ahead of print). This randomized, double-blind clinical trial investigates the effect of GLP-1 analogue ROSE-010 in humans, and shows that ROSE-010 is effective in pain relief response in IBS patients affected by pain attacks.
    • (2010) Acta Physiol (Oxf)
    • Hellström, P.M.1
  • 42
    • 68249119037 scopus 로고    scopus 로고
    • Review article: Visceral hypersensitivity in irritable bowel syndrome: Molecular mechanisms and therapeutic agents
    • 1:CAS:528:DC%2BD1MXhtFSqsbrK 10.1111/j.1365-2036.2009.04056.x 19493256
    • A Akbar JR Walters S Ghosh 2009 Review article: visceral hypersensitivity in irritable bowel syndrome: molecular mechanisms and therapeutic agents Aliment Pharmacol Ther 30 423 435 1:CAS:528:DC%2BD1MXhtFSqsbrK 10.1111/j.1365-2036.2009.04056.x 19493256
    • (2009) Aliment Pharmacol Ther , vol.30 , pp. 423-435
    • Akbar, A.1    Walters, J.R.2    Ghosh, S.3
  • 43
    • 69549118509 scopus 로고    scopus 로고
    • The endogenous hydrogen sulfide producing enzyme cystathionine-beta synthase contributes to visceral hypersensitivity in a rat model of irritable bowel syndrome
    • 10.1186/1744-8069-5-44 19660142
    • GY Xu JH Winston M Shenoy, et al. 2009 The endogenous hydrogen sulfide producing enzyme cystathionine-beta synthase contributes to visceral hypersensitivity in a rat model of irritable bowel syndrome Mol Pain 5 44 10.1186/1744-8069-5-44 19660142
    • (2009) Mol Pain , vol.5 , pp. 44
    • Xu, G.Y.1    Winston, J.H.2    Shenoy, M.3
  • 44
    • 56549129514 scopus 로고    scopus 로고
    • The gaseous mediator, hydrogen sulphide, inhibits in vitro motor patterns in the human, rat and mouse colon and jejunum
    • 1:CAS:528:DC%2BD1MXnsV2msg%3D%3D 10.1111/j.1365-2982.2008.01201.x 19019033
    • D Gallego P Clave J Donovan, et al. 2008 The gaseous mediator, hydrogen sulphide, inhibits in vitro motor patterns in the human, rat and mouse colon and jejunum Neurogastroenterol Motil 20 1306 1316 1:CAS:528:DC%2BD1MXnsV2msg%3D%3D 10.1111/j.1365-2982.2008.01201.x 19019033
    • (2008) Neurogastroenterol Motil , vol.20 , pp. 1306-1316
    • Gallego, D.1    Clave, P.2    Donovan, J.3
  • 45
    • 0034519915 scopus 로고    scopus 로고
    • Neurotransmitters in neuronal reflexes regulating intestinal secretion
    • 1:CAS:528:DC%2BD3MXntVChtQ%3D%3D 10.1111/j.1749-6632.2000.tb05225.x 11193603
    • HJ Cooke 2000 Neurotransmitters in neuronal reflexes regulating intestinal secretion Ann N Y Acad Sci 915 77 80 1:CAS:528:DC%2BD3MXntVChtQ%3D%3D 10.1111/j.1749-6632.2000.tb05225.x 11193603
    • (2000) Ann N y Acad Sci , vol.915 , pp. 77-80
    • Cooke, H.J.1
  • 46
    • 59849091580 scopus 로고    scopus 로고
    • Cholera toxin induces sustained hyperexcitability in submucosal secretomotor neurons in guinea pig jejunum
    • e294
    • Gwynne RM, Ellis M, Sjovall H, Bornstein JC: Cholera toxin induces sustained hyperexcitability in submucosal secretomotor neurons in guinea pig jejunum. Gastroenterology 2009, 136:299-308 e294.
    • (2009) Gastroenterology , vol.136 , pp. 299-308
    • Gwynne, R.M.1    Ellis, M.2    Sjovall, H.3    Bornstein, J.C.4
  • 48
    • 77955419649 scopus 로고    scopus 로고
    • Irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease: A real association or reflection of occult inflammation?
    • (Epub ahead of print). This article suggests that although IBS-like symptoms are common in patients with IBD, the mechanism in most cases is likely to be occult inflammation rather than coexistent IBS
    • Keohane J, O'Mahony C, O'Mahony L, et al.: Irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease: a real association or reflection of occult inflammation? Am J Gastroenterol 2010 (Epub ahead of print). This article suggests that although IBS-like symptoms are common in patients with IBD, the mechanism in most cases is likely to be occult inflammation rather than coexistent IBS.
    • (2010) Am J Gastroenterol
    • Keohane, J.1    O'Mahony, C.2    O'Mahony, L.3
  • 49
    • 33746897302 scopus 로고    scopus 로고
    • Regulation of inflammatory responses by sensory neurons: Molecular mechanism(s) and possible therapeutic applications
    • DOI 10.2174/092986706777935131
    • K Okajima N Harada 2006 Regulation of inflammatory responses by sensory neurons: molecular mechanism(s) and possible therapeutic applications Curr Med Chem 13 2241 2251 1:CAS:528:DC%2BD28XnslOksL8%3D 10.2174/092986706777935131 16918352 (Pubitemid 44184650)
    • (2006) Current Medicinal Chemistry , vol.13 , Issue.19 , pp. 2241-2251
    • Okajima, K.1    Harada, N.2
  • 50
    • 0034113232 scopus 로고    scopus 로고
    • Treatment of inflammatory bowel disease in a rodent model with the intestinal growth factor glucagon-like peptide-2
    • 1:STN:280:DC%2BD3cvps1Kitg%3D%3D 10.1053/jpsu.2000.6861 10873024
    • K Alavi MZ Schwartz JP Palazzo R Prasad 2000 Treatment of inflammatory bowel disease in a rodent model with the intestinal growth factor glucagon-like peptide-2 J Pediatr Surg 35 847 851 1:STN:280:DC%2BD3cvps1Kitg%3D%3D 10.1053/jpsu.2000.6861 10873024
    • (2000) J Pediatr Surg , vol.35 , pp. 847-851
    • Alavi, K.1    Schwartz, M.Z.2    Palazzo, J.P.3    Prasad, R.4
  • 51
    • 49749084030 scopus 로고    scopus 로고
    • Enteric nervous system abnormalities in inflammatory bowel diseases
    • 1:STN:280:DC%2BD1crivFKgtA%3D%3D 10.1111/j.1365-2982.2008.01146.x 18492026
    • V Villanacci G Bassotti R Nascimbeni, et al. 2008 Enteric nervous system abnormalities in inflammatory bowel diseases Neurogastroenterol Motil 20 1009 1016 1:STN:280:DC%2BD1crivFKgtA%3D%3D 10.1111/j.1365-2982.2008.01146.x 18492026
    • (2008) Neurogastroenterol Motil , vol.20 , pp. 1009-1016
    • Villanacci, V.1    Bassotti, G.2    Nascimbeni, R.3
  • 52
    • 0037254899 scopus 로고    scopus 로고
    • Role of enteric glial cells in inflammatory bowel disease
    • DOI 10.1002/glia.10169
    • J Cabarrocas TC Savidge RS Liblau 2003 Role of enteric glial cells in inflammatory bowel disease Glia 41 81 93 10.1002/glia.10169 12465048 (Pubitemid 36164287)
    • (2003) GLIA , vol.41 , Issue.1 , pp. 81-93
    • Cabarrocas, J.1    Savidge, T.C.2    Liblau, R.S.3
  • 53
    • 85018849773 scopus 로고    scopus 로고
    • Deficiency of interstitial cells of Cajal in the small intestine of patients with Crohn's disease
    • 10.1111/j.1572-0241.2002.05430.x 11808934
    • C Porcher M Baldo M Henry, et al. 2002 Deficiency of interstitial cells of Cajal in the small intestine of patients with Crohn's disease Am J Gastroenterol 97 118 125 10.1111/j.1572-0241.2002.05430.x 11808934
    • (2002) Am J Gastroenterol , vol.97 , pp. 118-125
    • Porcher, C.1    Baldo, M.2    Henry, M.3
  • 54
    • 67651219592 scopus 로고    scopus 로고
    • Extrinsic surgical denervation ameliorates TNBS-induced colitis in rats
    • 19621680
    • Y Takami CR Mantyh TN Pappas, et al. 2009 Extrinsic surgical denervation ameliorates TNBS-induced colitis in rats Hepatogastroenterology 56 682 686 19621680
    • (2009) Hepatogastroenterology , vol.56 , pp. 682-686
    • Takami, Y.1    Mantyh, C.R.2    Pappas, T.N.3
  • 56
    • 53249142340 scopus 로고    scopus 로고
    • Targeted deletion of neuropeptide y (NPY) modulates experimental colitis
    • 10.1371/journal.pone.0003304 18836554
    • B Chandrasekharan V Bala VL Kolachala, et al. 2008 Targeted deletion of neuropeptide Y (NPY) modulates experimental colitis PLoS One 3 e3304 10.1371/journal.pone.0003304 18836554
    • (2008) PLoS One , vol.3 , pp. 3304
    • Chandrasekharan, B.1    Bala, V.2    Kolachala, V.L.3


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