Transcriptome analysis indicates an enhanced activation of adaptive and innate immunity by Chlamydia-infected murine epithelial cells treated with interferon γ

Journal of Infectious Diseases

Volumn 202, Issue 9, 2010, Pages 1405-1414

  Burian, Katalin ^a   Endresz, Valeria ^a   Deak, Judit ^a   Kormanyos, Zsolt ^a   Pal, Attila ^a   Nelson, David ^c   Virok, Dezso P ^b  

^a UNIVERSITY OF SZEGED   (Hungary)

^b Institute for Plant Genomics Human Biotechnology and Bioenergy (BAY GEN)   (Hungary)

^c INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CXCL9 CHEMOKINE; DNA; GUANOSINE TRIPHOSPHATASE; INDUCIBLE NITRIC OXIDE SYNTHASE; PROTEIN P47; TRANSCRIPTOME; INTERFERON;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIGEN PRESENTATION; APOPTOSIS; ARTICLE; BACTERIAL STRAIN; CHLAMYDIA; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; EPITHELIUM CELL; FATTY ACID OXIDATION; GENE EXPRESSION; GENETIC ANALYSIS; INNATE IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTOMICS; UPREGULATION; ANIMAL; CELL LINE; GENE EXPRESSION PROFILING; IMMUNOLOGY; MICROBIOLOGY;

ANIMALS; CELL LINE; CHLAMYDIA MURIDARUM; CHLAMYDIA TRACHOMATIS; EPITHELIAL CELLS; GENE EXPRESSION PROFILING; INTERFERONS; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 77958111626     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/656526     Document Type: Article

References (39)

1. Rasmussen SJ, Eckmann L, Quayle AJ, et al. Secretion of proinflammatory cytokines by epithelial cells in response to chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis. J Clin Invest 1997; 99:77-87. (Pubitemid 27058297)
2. Stephens RS. The cellular paradigm of chlamydial pathogenesis. Trends Microbiol 2003; 11:44-51.
3. Morrison RP, Caldwell HD. Immunity to murine chlamydial genital infection. Infect Immun 2002; 70:2741-2751. (Pubitemid 34564127)
4. Brunham RC, Peeling RW. Chlamydia trachomatis antigens: role in immunity and pathogenesis. Infect Agents Dis 1994; 3:218-233.
5. Morrison SG, Morrison RP. In situ analysis of the evolution of the primary immune response in murine Chlamydia trachomatis genital tract infection. Infect Immun 2000; 68:2870-2879.
6. Rodriguez N, Mages J, Dietrich H, et al. MyD88-dependent changes in the pulmonary transcriptome after infection with Chlamydia pneumoniae. Physiol Genomics 2007; 30:134-145.
7. Derbigny WA, Kerr MS, Johnson RM. Pattern recognition molecules activated by Chlamydia muridarum infection of cloned murine oviduct epithelial cell lines. J Immunol 2005; 175:6065-6075.
8. Nelson DE, Virok DP,Wood H, et al. Chlamydial IFN-gamma immune evasion is linked to host infection tropism. Proc Natl Acad Sci U S A 2005; 102:10658-10663.
9. Johnson RM. Murine oviduct epithelial cell cytokine responses to Chlamydia muridarum infection include interleukin-12-p70 secretion. Infect Immun 2004; 72:3951-3960.
10. Caldwell HD, Kromhout J, Schachter J. Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis. Infect Immun 1981; 31:1161-1176.
11. + T cells play a significant role in adoptive immunity to Chlamydia trachomatis infection of the mouse genital tract. Infect Immun 1995; 63:3302-3308.
12. Rajagopalan D. A comparison of statistical methods for analysis of high density oligonucleotide array data. Bioinformatics 2003; 19:1469-1476. (Pubitemid 37038862)
13. Sturn A, Quackenbush J, Trajanoski Z. Genesis: cluster analysis of microarray data. Bioinformatics 2002; 18:207-208. (Pubitemid 34145055)
14. Sherman BT, Huang da W, Tan Q, et al. DAVID Knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis. BMC Bioinformatics 2007; 8:426.
15. Jensen LJ, Kuhn M, Stark M, et al. STRING 8 - a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res 2009; 37:D412-D416.
16. Dobo J, Harmat V, Beinrohr L, Sebestyen E, Zavodszky P, Gal P. MASP-1, a promiscuous complement protease: structure of its catalytic region reveals the basis of its broad specificity. J Immunol 2009; 183:1207-1214.
17. Ashburner M, Ball CA, Blake JA, et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 2000; 25:25-29.
18. Virok DP, Nelson DE, Whitmire WM, Crane DD, Goheen MM, Caldwell HD. Chlamydial infection induces pathobiotype-specific protein tyrosine phosphorylation in epithelial cells. Infect Immun 2005; 73:1939-1946.
19. Beutler B, Hoebe K, Shamel L. Forward genetic dissection of afferent immunity: the role of TIR adapter proteins in innate and adaptive immune responses. C R Biol 2004; 327:571-580. (Pubitemid 38979507)
20. Prebeck S, Kirschning C, Durr S, et al. Predominant role of toll-like receptor 2 versus 4 in Chlamydia pneumoniae-induced activation of dendritic cells. J Immunol 2001; 167:3316-3323.
21. O'Connell CM, Ionova IA, Quayle AJ, Visintin A, Ingalls RR. Localization of TLR2 and MyD88 to Chlamydia trachomatis inclusions. Evidence for signaling by intracellular TLR2 during infection with an obligate intracellular pathogen. J Biol Chem 2006; 281:1652-1659.
22. Prantner D, Darville T, Nagarajan UM. Stimulator of IFN Gene Is Critical for Induction of IFN-(beta) during Chlamydia muridarum infection. J Immunol 2010; 184:2551-2560.
23. Lippmann J, Rothenburg S, Deigendesch N, et al. IFNbeta responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI). Cell Microbiol 2008; 10:2579-2588.
24. Takaoka A, Wang Z, Choi MK, et al. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 2007; 448:501-505. (Pubitemid 47123520)
25. Yee YK, Chintalacharuvu SR, Lu J, Nagpal S. Vitamin D receptor modulators for inflammation and cancer. Mini Rev Med Chem 2005; 5:761-778. (Pubitemid 41051899)
26. Gonda TJ. The c-Myb oncoprotein. Int J Biochem Cell Biol 1998; 30:547-551.
27. Cole AM, Ganz T, Liese AM, Burdick MD, Liu L, Strieter RM. Cutting edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity. J Immunol 2001; 167:623-627. (Pubitemid 32660811)
28. Egesten A, Eliasson M, Johansson HM, et al. The CXC chemokine MIG/CXCL9 is important in innate immunity against Streptococcus pyogenes. J Infect Dis 2007; 195:684-693.
29. Sauty A, Dziejman M, Taha RA, et al. The T cell-specific CXC chemokines IP-10, Mig, and I-TAC are expressed by activated human bronchial epithelial cells. J Immunol 1999; 162:3549-3558. (Pubitemid 29313608)
30. Beatty WL, Belanger TA, Desai AA, Morrison RP, Byrne GI. Role of tryptophan in gamma interferon-mediated chlamydial persistence. Ann N Y Acad Sci 1994; 730:304-306. (Pubitemid 24292236)
31. Tipples G, McClarty G. The obligate intracellular bacteriumChlamydia trachomatis is auxotrophic for three of the four ribonucleoside triphosphates. Mol Microbiol 1993; 8:1105-1114.
32. Burian K, Hegyesi H, Buzas E, et al. Chlamydophila (Chlamydia) pneumoniae induces histidine decarboxylase production in the mouse lung. Immunol Lett 2003; 89:229-236.
33. Kuo CC, Grayston JT. Amino acid requirements for growth of Chlamydia pneumoniae in cell cultures: growth enhancement by lysine or methionine depletion. J Clin Microbiol 1990; 28:1098-1100.
34. Cao D, Leffert JJ, McCabe J, Kim B, Pizzorno G. Abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene. J Biol Chem 2005; 280:21169-21175. (Pubitemid 40805678)
35. Read TD, Brunham RC, Shen C, et al. Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39. Nucleic Acids Res 2000; 28:1397-1406.
36. Roshick C,Wood H, Caldwell HD, McClarty G. Comparison of gamma interferon-mediated antichlamydial defense mechanisms in human and mouse cells. Infect Immun 2006; 74:225-238. (Pubitemid 43023077)
37. Agrawal T, Vats V, Salhan S, Mittal A. Local markers for prediction of women at higher risk of developing sequelae to Chlamydia trachomatis infection. Am J Reprod Immunol 2007; 57:153-159.
38. Bobo L, Novak N, Mkocha H, Vitale S, West S, Quinn TC. Evidence for a predominant proinflammatory conjunctival cytokine response in individuals with trachoma. Infect Immun 1996; 64:3273-3279. (Pubitemid 26256176)
39. Srivastava P, Jha R, Bas S, Salhan S, Mittal A. In infertile women, cells from Chlamydia trachomatis infected sites release higher levels of interferon-gamma, interleukin-10 and tumor necrosis factor-alpha upon heat-shock-protein stimulation than fertile women. Reprod Biol Endocrinol 2008; 6:20.