Synthesis and biological properties of a rhodacyanine derivative, SSJ-127, having high efficacy against malaria protozoa

Heterocycles

Volumn 77, Issue 1, 2009, Pages 207-210

  Pudhom, Khanitha ^a   Ge, Jian Feng ^a   Arai, Chika ^a,b   Yang, Mei ^a,b   Kaiser, Marcel ^c   Wittlin, Sergio ^c   Brun, Reto ^c   Itoh, Isamu ^a,b   Ihara, Masataka ^a,b  

^a HOSHI UNIVERSITY   (Japan)

^b Japan Port Consultants Ltd   (Japan)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

Antimalarial; Cytotoxicity; Plasmodium berghei; Rhodacyanine; Trypanosoma brucei rhodesiense

Indexed keywords

EID: 65649152075     PISSN: 03855414     EISSN: None     Source Type: Journal    
DOI: 10.3987/COM-08-S(F)35     Document Type: Article

References (14)

1. Snow R.W., Guerra C.A., Noor A.M., Myint H.Y., and Hay S.I. Nature 434 (2005) 214
2. Peter W. Br. Med. Bull 38 (1982) 187
3. Wernsdorfer W.H., and Pyne D. Pharmacol. Ther. 50 (1991) 95
4. White N. J. Antimicrob. Chemother. 30 (1992) 571
5. Olliaro P.L., and Yuthavong Y. Pharmacol. Ther. 81 (1999) 91
6. Go M.-L. Med. Res. Rev. 23 (2003) 456
7. Thayer A.M. Chem. Eng. News 83 (2005) 69
8. Takasu K., Inoue H., Kim H.-S., Suzuki M., Shishido T., Wataya Y., and Ihara M. J. Med. Chem. 45 (2002) 995
9. Takasu K., Morisaki D., Kaiser M., Brun R., and Ihara M. Hetrerocycles 66 (2005) 162
10. Pudhom K., Kasai K., Terauchi H., Inoue H., Kaiser M., Brun R., Ihara M., and Takasu K. Bioorg. Med. Chem. 14 (2006) 8550
11. Takasu K., Pudhom K., Kaiser M., Brun R., and Ihara M. J. Med. Chem. 49 (2006) 4795
12. 2O: C, 47.29; H, 5.52; N, 9.59. Found: C, 47.03; H, 5.19; N, 9.41.
13. Kawakami M., Koya K., Ukai T., Tatsuta N., Ikegawa A., Ogawa K., Shishido T., and Chen L.B. J. Med. Chem. 40 (1997) 3151
14. Kawakami M., Koya K., Ukai T., Tatsuta N., Ikegami A., Ogawa K., Shishido T., and Chen L.B. J. Med. Chem. 41 (1998) 130