Polymodal TRPC signaling: Emerging role in phenotype switching and tissue remodeling

Communicative and Integrative Biology

Volumn 3, Issue 5, 2010, Pages 393-395

  Groschner, Klaus ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

Ca2+ signaling; Cell cell contacts; Endothelial phenotype switching; Transient receptor potential channel 4

Indexed keywords

EID: 77958089822     PISSN: None     EISSN: 19420889     Source Type: Journal    
DOI: 10.4161/cib.3.5.12131     Document Type: Review

References (44)

1. Venkatachalam K, Montell C. TRP channels. Annu Rev Biochem 2007; 76:387-417.
2. Vazquez G, Wedel BJ, Aziz O, Trebak M, Putney JW Jr. The mammalian TRPC cation channels. Biochim Biophys Acta 2004; 1742:21-36.
3. Pedersen SF, Owsianik G, Nilius B. TRP channels: An overview. Cell Calcium 2005; 38:233-52.
4. Birnbaumer L. The TRPC class of ion channels: a critical review of their roles in slow, sustained increases in intracellular Ca(2+) concentrations. Annu Rev Pharmacol Toxicol 2009; 49:395-426.
5. 2+ entry. Cell 1996; 85:661-71.
6. Liu X, et al. Trp1, a candidate protein for the storeoperated Ca(2+) influx mechanism in salivary gland cells. J Biol Chem 2000; 275:3403-11.
7. Ng LC, Gurney AM. Store-operated channels mediate Ca(2+) influx and contraction in rat pulmonary artery. Circ Res 2001; 89:923-9.
8. Groschner K, et al. Trp proteins form store-operated cation channels in human vascular endothelial cells. FEBS Lett 1998; 437:101-6.
9. -/-mice. Nat Cell Biol 2001; 3:121-7.
10. 2+-like channels in adrenal cells. J Biol Chem 2000; 275:23965-72.
11. Hofmann T, et al. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 1999; 397:259-63.
12. 2+-sensitive cation channels. J Biol Chem 2000; 275:27799-805.
13. Schaefer M, et al. Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5. J Biol Chem 2000; 275:17517-26.
14. Zitt C, et al. Expression of TRPC3 in Chinese hamster ovary cells results in calcium-activated cation currents not related to store depletion. J Cell Biol 1997; 138:1333-41.
15. Yuan JP, et al. Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell 2003; 114:777-89.
16. Treves S, et al. Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion. J Cell Biol 2004; 166:537-48.
17. 2+ channels. Science 2000; 287:1647-51.
18. Liao Y, et al. Functional interactions among Orai1, TRPCs and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels. Proc Natl Acad Sci USA 2008; 105:2895-900.
19. Kiselyov K, et al. Functional interaction between InsP3 receptors and store-operated Htrp3 channels. Nature 1998; 396:478-82.
20. Kiselyov K, Mignery GA, Zhu MX, Muallem S. The N-terminal domain of the IP3 receptor gates storeoperated hTrp3 channels. Mol Cell 1999; 4:423-9.
21. Huang GN, et al. STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels. Nat Cell Biol 2006; 8:1003-10.
22. Woo JS, Kim do H, Allen PD, Lee EH. TRPC3-interacting triadic proteins in skeletal muscle. Biochem J 2008; 411:399-405.
23. Strubing C, Krapivinsky G, Krapivinsky L, Clapham DE. TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 2001; 29:645-55.
24. Strubing C, Krapivinsky G, Krapivinsky L, Clapham DE. Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J Biol Chem 2003; 278:39014-9.
25. Poteser M, et al. TRPC3 and TRPC 4 associate to form a redox-sensitive cation channel-evidence for expression of native trpc3/trpc4 heteromeric channels in endothelial cells. J Biol Chem 2006; 281:13588-95.
26. Yuan JP, Zeng W, Huang GN, Worley PF, Muallem S. STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nat Cell Biol 2007; 9:636-45.
27. Zeng W, et al. STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction. Mol Cell 2008; 32:439-48.
28. Cheng KT, Liu X, Ong HL, Ambudkar IS. Functional requirement for Orai1 in store-operated TRPC1-STIM1 channels. J Biol Chem 2008; 283:12935-40.
29. Mery L, Strauss B, Dufour JF, Krause KH, Hoth M. The PDZ-interacting domain of TRPC4 controls its localization and surface expression in HEK293 cells. J Cell Sci 2002; 115:3497-508.
30. Obukhov AG, Nowycky MC. TRPC5 activation kinetics are modulated by the scaffolding protein ezrin/radixin/moesin-binding phosphoprotein-50 (EBP50). J Cell Physiol 2004; 201:227-35.
31. Otsuguro K, et al. Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate. J Biol Chem 2008; 283:10026-36.
32. Blair NT, Kaczmarek JS, Clapham DE. Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. J Gen Physiol 2009; 133:525-46.
33. Trebak M, Bird GS, McKay RR, Putney JW Jr. Comparison of human TRPC3 channels in receptor-activated and store-operated modes. Differential sensitivity to channel blockers suggests fundamental differences in channel composition. J Biol Chem 2002; 277:21617-23.
34. 2+ entry. Am J Physiol Cell Physiol 2005; 288:872-80.
35. Trebak M, Vazquez G, Bird GS, Putney JW Jr. The TRPC3/6/7 subfamily of cation channels. Cell Calcium 2003; 33:451-61.
36. Groschner K, Rosker C. TRPC3: a versatile transducer molecule that serves integration and diversification of cellular signals. Naunyn Schmiedebergs Arch Pharmacol 2005; 371:251-6.
37. 2+ entry. Proc Natl Acad Sci USA 2009; 106:3202-6.
38. Eder P, Groschner K. TRPC3/6/7: Topical aspects of biophysics and pathophysiology. Channels 2008; 2:94-9.
39. Freichel M, et al. Functional role of TRPC proteins in vivo: lessons from TRPC-deficient mouse models. Biochem Biophys Res Commun 2004; 322:1352-8.
40. Cioffi DL, Stevens T. Regulation of endothelial cell barrier function by store-operated calcium entry. Microcirculation 2006; 13:709-23.
41. 2+ entry in TRPC4(-/-) mice interferes with increase in lung microvascular permeability. Circ Res 2002; 91:70-6.
42. 2+ signaling in the regulation of endothelial permeability. Vascul Pharmacol 2002; 39:173-85.
43. Abdullaev IF, et al. Stim1 and Orai1 mediate CRAC currents and store-operated calcium entry important for endothelial cell proliferation. Circ Res 2008; 103:1289-99.
44. 2+ signaling by TRPC4 in the vascular endothelium: Evidence for a regulatory TRPC4-{beta}-catenin interaction. J Biol Chem 2009; 285:4213-23.