Design, synthesis and reactivity of C2-symmetric azobenzene-based amino acid-bis(propargyl sulfones)

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 22, 2010, Pages 6831-6835

  Mitra, Debarati ^a   Banerjee, Deb Ranjan ^a   Das, Amit Kumar ^a   Basak, Amit ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Amino acid; Azobenzene; DNA cleavage; Irradiation; Propargyl sulfones

Indexed keywords

AZOBENZENE; C2 SYMMETRIC AZOBENZENE AMINO ACID LINKED BIS(PROPARGYL SULFONES); SULFONE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; DNA CLEAVAGE; DRUG DESIGN; DRUG SYNTHESIS; ISOMER; ISOMERIZATION; PH; ULTRAVIOLET IRRADIATION;

ALKYNES; AMINO ACIDS; AZO COMPOUNDS; DRUG DESIGN; ISATIN; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 77958056478     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.085     Document Type: Article

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28. The cleavage efficiency was determined by checking the relative UV-absorbance of the bands at 260 nm. The cleavage efficiency was also measured by densitometry using image processing software (Kodak 1D version V.3.6.3) and similar results were obtained. The identity of the bands has been ascertained from the control DNA which has form I as a major band. It is to be noted that the control DNA specimen is usually contaminated with some nicked form (form II). The reason for having alkaline pH 8.5 was to aid the propargyl to allene isomerization.
29. The DNA-binding studies were carried out by absorption titrations which involved addition of a solution of Calf Thymus DNA to a fixed concentration of the probe. A small red shift of the absorption maxima for both the E-sulfones (375 nm) and Z-sulfones (a shoulder near 438 nm) was observed.