Synthesis and reactivity of azobenzene-based bispropargyl sulfones: Interesting comparison between cyclic and acyclic systems

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 16, 2007, Pages 4514-4517

  Mitra, Debarati ^a   Kar, Moumita ^a   Pal, Rhitankar ^a   Basak, Amit ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Azobenzene; Bispropargyl; DNA cleavage; Photoisomerization; Sulfone

Indexed keywords

AZOBENZENE DERIVATIVE; BISPROPARGYL SULFONE; SULFONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRESS; DNA CLEAVAGE; ISOMERIZATION; KINETICS; SYNTHESIS; ULTRAVIOLET RADIATION;

ANTINEOPLASTIC AGENTS; AZO COMPOUNDS; DNA CLEAVAGE; MOLECULAR STRUCTURE; SULFONES;

EID: 34447302562     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.06.001     Document Type: Article

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16. The DNA used for the present study is pBR322 plasmid DNA in mainly the supercoiled form. The identity of the bands has been ascertained from the control DNA which has Form I as a major band. The cleavage efficiency was determined by checking the relative UV-absorbance of the bands at 260 nm. The cleavage efficiency was also measured by densitometry using image processing software (Kodak 1D version V.3.6.3) and similar results were obtained. It is to be noted that the control DNA specimen is usually contaminated with some nicked form (form II). The reason for having an alkaline pH of 8.5 was to aid the propargyl to allene isomerization.
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