Sequential cytotoxicity: A theory examined using a series of 3,5-bis(benzylidene)-1-diethylphosphono-4-oxopiperidines and related phosphonic acids

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 22, 2010, Pages 6464-6468

  Das, Swagatika ^a   Das, Umashankar ^a   Sakagami, Hiroshi ^b   Hashimoto, Ken ^b   Kawase, Masami ^c   Gorecki, Dennis K J ^a   Dimmock, Jonathan R ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b MEIKAI UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

^c MATSUYAMA UNIVERSITY   (Japan)

Author keywords

Caspase activation; Neoplasms; QSAR; Selective toxicity; Sequential cytotoxicity

Indexed keywords

3,5 BIS(BENZYLIDENE) 1 DIETHYLPHOSPHONO 4 OXOPIPERIDINE; CASPASE 3; CYTOTOXIC AGENT; CYTOTOXIN; MELPHALAN; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL STRAIN HL 60; CYTOTOXICITY; DNA FRAGMENTATION; DRUG POTENCY; DRUG STRUCTURE; ELECTRON; ENZYME ACTIVATION; FIBROBLAST; HUMAN; HUMAN CELL; IN VITRO STUDY; PHYSICAL CHEMISTRY; PLEIOTROPY; PROMYELOCYTIC LEUKEMIA; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SQUAMOUS CELL CARCINOMA;

CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PHOSPHONIC ACIDS; PIPERIDINES;

EID: 77958049387     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.09.051     Document Type: Article

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