Beta cell adaptation in pregnancy: A major difference between humans and rodents?

Diabetologia

Volumn 53, Issue 10, 2010, Pages 2089-2092

  Genevay, M ^a   Pontes, H ^b   Meda, P ^b  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Beta cell adaptation; Beta cell apoptosis; Beta cell mass; Beta cell proliferation; CX36; Human beta cells; Islet neogenesis; Pregnancy; Prolactin

Indexed keywords

INSULIN;

APOPTOSIS; CELL FUNCTION; CELL PROLIFERATION; CELL SURVIVAL; GENETIC REGULATION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULIN RESISTANCE; NONHUMAN; NOTE; PANCREAS ISLET BETA CELL; PREGNANCY; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL; RODENT;

ANIMALS; FEMALE; HUMANS; INSULIN-SECRETING CELLS; PREGNANCY; RATS; SPECIES SPECIFICITY;

EID: 77958040979     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1848-z     Document Type: Note

References (27)

1. Sorenson RL, Brelje TC (1997) Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones. Horm Metab Res 29:301-307
2. Rieck S, Kaestner KH (2010) Expansion of beta-cell mass in response to pregnancy. Trends Endocrinol Metab 21:151-158
3. Hellmann B (1960) The islets of Langerhans in the rat during pregnancy and lactation, with special reference to the changes in the B/A cell ratio. Acta Obstet Gynecol Scand 39:331-342
4. Van Assche FA (1974) Quantitative morphologic and histoenzymatic study of the endocrine pancreas in nonpregnant and pregnant rats. Am J Obstet Gynecol 118:39-11
5. Parsons JA, Brelje TC, Sorenson RL (1992) Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion. Endocrinology 130:1459-1466
6. Moldrup A, Petersen ED, Nielsen JH (1993) Effects of sex and pregnancy hormones on growth hormone and prolactin receptor gene expression in insulin-producing cells. Endocrinology 133:1165-1172
7. Scaglia L, Smith FE, Bonner-Weir S (1995) Apoptosis contributes to the involution of beta cell mass in the post partum rat pancreas. Endocrinology 136:5461-5468
8. Jiang Y, Nishimura W, Devor-Henneman D et al (2008) Postnatal expansion of the pancreatic β-cell mass is dependent on survivin. Diabetes 57:2718-2727
9. Karnik SK, Chen H, McLean GW et al (2007) Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus. Science 318:806-809
10. Rieck S, White P, Schug J et al (2009) The transcriptional response of the islet to pregnancy in mice. Mol Endocrinol 23:1702-1712
11. Costrini NV, Kalkhoff RK (1991) Relative effects of pregnancy, estradiol and progesterone on plasma insulin and pancreatic islet content. J Clin Invest 50:992-999
12. Green IC, Taylor KW (1972) Effects of pregnancy in the rat on the size and insulin secretory response of the islets of Langerhans. J Endocrinol 54:317-325
13. Weinhaus AJ, Stout LE, Bhagroo NV, Brelje TC, Sorenson RL (2007) Regulation of glucokinase in pancreatic islets by prolactin: a mechanism for increasing glucose-stimulated insulin secretion during pregnancy. J Endocrinol 193:367-381
14. Sorenson RL, Brelje TC, Hegre OD, Marshall S, Anaya P, Sheridan JD (1987) Prolactin (in vitro) decreases the glucose stimulation threshold, enhances insulin secretion, and increases dye coupling among islet B cells. Endocrinology 121:1447-1453
15. Van Assche FA, Aerts L, De Prins F (1978) A morphological study of the endocrine pancreas in human pregnancy. Br J Obstet Gynaecol 85:818-820
16. Fiaschi-Taesch N, Bigatel TA, Sicari B et al (2009) Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta- cell replication and function in vivo. Diabetes 58:882-893
17. Tschen SI, Dhawan S, Gurlo T, Bhushan A (2009) Age-dependent decline in beta cell proliferation restricts the capacity of beta cell regeneration in mice. Diabetes 58:1312-1320
18. Butler AE, Cao-Minh L, Galasso R et al. (2010) Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy. Diabetologia. doi:10.1007/s00125-010-1809-6
19. Xu X, D'Hoker J, Stangé G et al (2008) Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 132:197-207
20. Klöppel G, Bommer G, Commandeur G, Heitz P (1978) The endocrine pancreas in chronic pancreatitis. Immunocytochemical and ultrastructural studies. Virchows Arch A Pathol Anat Histol 377:157-174
21. Serre-Beinier V, Bosco D, Zulianello L et al (2009) Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression. Hum Mol Genet 18:428-439
22. Nielsen LR, Rehfeld JF, Pedersen-Bjergaard U, Damm P, Mathiesen ER (2009) Pregnancy-induced rise in serum C- peptide concentrations in women with type 1 diabetes. Diabetes Care 32:1052-1057
23. Carvalho CP, Barbosa HC, Britan A et al (2010) Beta cell coupling and connexin expression change during the functional maturation of rat pancreatic islets. Diabetologia 53:1428-1437
24. Ravier MA, Güldenagel M, Charollais A et al (2005) Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release. Diabetes 54:1798-1807
25. Devlieger R, Casteels K, van Assche FA (2008) Reduced adaptation of the pancreatic B cells during pregnancy is the major causal factor for gestational diabetes: current knowledge and metabolic effects on the offspring. Acta Obstet Gynecol Scand 87:1266-1270
26. Catalano PM, Tyzbir ED, Roman NM, Amini SB, Sims EA (1991) Longitudinal changes in insulin release and insulin resistance in nonobese pregnant women. Am J Obstet Gynecol 165:1667-1672
27. Buchanan TA, Metzger BE, Freinkel N, Bergman RN (1990) Insulin sensitivity and B cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes. Am J Obstet Gynecol 162:1008-1014