Method for the rapid detection and molecular characterization of DNA alkylating agents by MALDI-TOF mass spectrometry

Analytical Chemistry

Volumn 82, Issue 20, 2010, Pages 8573-8582

  Garaguso, Ignazio ^a,b   Halter, Roman ^a   Krzeminski, Jacek ^c   Amin, Shantu ^c   Borlak, Jürgen ^a,b  

^a FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENTS; BENZO [A] PYRENE; CHEMICAL NATURE; CHRYSENE; COLLISION INDUCED DISSOCIATION; COMPREHENSIVE INFORMATION; CYTIDINE; DIHYDROXYBENZOIC ACIDS; DINUCLEOTIDES; DNA ADDUCTS; ENZYMATIC DIGESTIONS; GUANOSINES; MALDI TOF MS; MALDI-MS; MALDI-TOF MASS SPECTROMETRY; MASS ACCURACY; MATRIX LAYERS; METABOLIC ACTIVATION; MOLECULAR CHARACTERIZATION; RAPID DETECTION; SAMPLE PREPARATION; SENSITIVE METHOD; SOLID-PHASE EXTRACTION; STRUCTURAL CHARACTERIZATION;

ACIDS; DNA; EXTRACTION; MASS SPECTROMETRY; MUTAGENS; NUCLEOTIDES; POLYCYCLIC AROMATIC HYDROCARBONS;

AROMATIC HYDROCARBONS;

ALKYLATING AGENT; CALF THYMUS DNA; DNA;

ANIMAL; ARTICLE; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; DNA ADDUCT; EVALUATION; HYDROLYSIS; MASS SPECTROMETRY; METHODOLOGY; TIME;

ALKYLATING AGENTS; ANIMALS; CATTLE; DNA; DNA ADDUCTS; HYDROLYSIS; MOLECULAR STRUCTURE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS;

EID: 77958028249     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac101568h     Document Type: Article

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