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Volumn 107, Issue 37, 2010, Pages 16240-16245

Ubiquitination of lysine-331 by Kaposi's sarcoma-associated herpesvirus protein K5 targets HFE for lysosomal degradation

Author keywords

Hemochromatosis; Immunology; Iron

Indexed keywords

HERPESVIRUS PROTEIN K5; LYSINE; LYSINE 331; TRANSFERRIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; CD71 ANTIGEN; HFE PROTEIN, HUMAN; HLA ANTIGEN CLASS 1; IMMEDIATE EARLY PROTEIN; K5 PROTEIN, HUMAN HERPESVIRUS 8; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; TRANSFERRIN RECEPTOR; UBIQUITIN;

EID: 77958022496     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1003421107     Document Type: Article
Times cited : (16)

References (34)
  • 2
    • 45749100909 scopus 로고    scopus 로고
    • Viral infection and iron metabolism
    • Drakesmith H, Prentice A (2008) Viral infection and iron metabolism. Nat Rev Microbiol 6:541-552.
    • (2008) Nat Rev Microbiol , vol.6 , pp. 541-552
    • Drakesmith, H.1    Prentice, A.2
  • 3
    • 9344224529 scopus 로고    scopus 로고
    • A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
    • Feder JN, et al. (1996) A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 13:399-408.
    • (1996) Nat Genet , vol.13 , pp. 399-408
    • Feder, J.N.1
  • 4
    • 2042546096 scopus 로고    scopus 로고
    • Balancing acts: Molecular control of mammalian iron metabolism
    • Hentze MW, Muckenthaler MU, Andrews NC (2004) Balancing acts: Molecular control of mammalian iron metabolism. Cell 117:285-297.
    • (2004) Cell , vol.117 , pp. 285-297
    • Hentze, M.W.1    Muckenthaler, M.U.2    Andrews, N.C.3
  • 5
    • 0032478524 scopus 로고    scopus 로고
    • Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor
    • Lebrón JA, et al. (1998) Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. Cell 93:111-123.
    • (1998) Cell , vol.93 , pp. 111-123
    • Lebrón, J.A.1
  • 6
    • 0033605595 scopus 로고    scopus 로고
    • The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells
    • Roy CN, Penny DM, Feder JN, Enns CA (1999) The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells. J Biol Chem 274:9022-9028.
    • (1999) J Biol Chem , vol.274 , pp. 9022-9028
    • Roy, C.N.1    Penny, D.M.2    Feder, J.N.3    Enns, C.A.4
  • 7
    • 2942554825 scopus 로고    scopus 로고
    • HFE and transferrin directly compete for transferrin receptor in solution and at the cell surface
    • Giannetti AM, Björkman PJ (2004) HFE and transferrin directly compete for transferrin receptor in solution and at the cell surface. J Biol Chem 279:25866-25875.
    • (2004) J Biol Chem , vol.279 , pp. 25866-25875
    • Giannetti, A.M.1    Björkman, P.J.2
  • 8
    • 0033485885 scopus 로고    scopus 로고
    • HFE downregulates iron uptake from transferrin and induces iron-regulatory protein activity in stably transfected cells
    • Riedel HD, et al. (1999) HFE downregulates iron uptake from transferrin and induces iron-regulatory protein activity in stably transfected cells. Blood 94:3915-3921.
    • (1999) Blood , vol.94 , pp. 3915-3921
    • Riedel, H.D.1
  • 9
    • 0041422148 scopus 로고    scopus 로고
    • Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation
    • Zhang AS, Davies PS, Carlson HL, Enns CA (2003) Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation. Proc Natl Acad Sci USA 100:9500-9505.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 9500-9505
    • Zhang, A.S.1    Davies, P.S.2    Carlson, H.L.3    Enns, C.A.4
  • 10
    • 15244342393 scopus 로고    scopus 로고
    • The hereditary hemochromatosis protein, HFE, lowers intracellular iron levels independently of transferrin receptor 1 in TRVb cells
    • Carlson H, Zhang AS, Fleming WH, Enns CA (2005) The hereditary hemochromatosis protein, HFE, lowers intracellular iron levels independently of transferrin receptor 1 in TRVb cells. Blood 105:2564-2570.
    • (2005) Blood , vol.105 , pp. 2564-2570
    • Carlson, H.1    Zhang, A.S.2    Fleming, W.H.3    Enns, C.A.4
  • 11
    • 0037180545 scopus 로고    scopus 로고
    • The hemochromatosis protein HFE inhibits iron export from macrophages
    • Drakesmith H, et al. (2002) The hemochromatosis protein HFE inhibits iron export from macrophages. Proc Natl Acad Sci USA 99:15602-15607.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15602-15607
    • Drakesmith, H.1
  • 12
    • 2942537827 scopus 로고    scopus 로고
    • Expression of the hereditary hemochromatosis protein HFE increases ferritin levels by inhibiting iron export in HT29 cells
    • Davies PS, Enns CA (2004) Expression of the hereditary hemochromatosis protein HFE increases ferritin levels by inhibiting iron export in HT29 cells. J Biol Chem 279: 25085-25092.
    • (2004) J Biol Chem , vol.279 , pp. 25085-25092
    • Davies, P.S.1    Enns, C.A.2
  • 13
    • 0037460697 scopus 로고    scopus 로고
    • Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
    • Bridle KR, et al. (2003) Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet 361:669-673.
    • (2003) Lancet , vol.361 , pp. 669-673
    • Bridle, K.R.1
  • 14
    • 33644876815 scopus 로고    scopus 로고
    • A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
    • Wang RH, et al. (2005) A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab 2:399-409.
    • (2005) Cell Metab , vol.2 , pp. 399-409
    • Wang, R.H.1
  • 15
    • 63449103712 scopus 로고    scopus 로고
    • BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
    • Andriopoulos B, Jr, et al. (2009) BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet 41:482-487.
    • (2009) Nat Genet , vol.41 , pp. 482-487
    • Andriopoulos Jr., B.1
  • 16
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver
    • DOI 10.1074/jbc.M008922200
    • Park CH, Valore EV, Waring AJ, Ganz T (2001) Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276:7806-7810. (Pubitemid 37385573)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.11 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 17
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, et al. (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306:2090-2093.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1
  • 18
    • 60649103774 scopus 로고    scopus 로고
    • Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression
    • Gao J, et al. (2009) Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression. Cell Metab 9:217-227.
    • (2009) Cell Metab , vol.9 , pp. 217-227
    • Gao, J.1
  • 19
  • 20
    • 0034608951 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis
    • Coscoy L, Ganem D (2000) Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis. Proc Natl Acad Sci USA 97:8051-8056.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 8051-8056
    • Coscoy, L.1    Ganem, D.2
  • 21
    • 3042836376 scopus 로고    scopus 로고
    • Iron: A target for the management of Kaposi's sarcoma?
    • Simonart T (2004) Iron: A target for the management of Kaposi's sarcoma? BMC Cancer 4:1-8.
    • (2004) BMC Cancer , vol.4 , pp. 1-8
    • Simonart, T.1
  • 22
    • 0027484120 scopus 로고
    • Endemic Kaposi's sarcoma in Africa and local volcanic soils
    • Ziegler JL (1993) Endemic Kaposi's sarcoma in Africa and local volcanic soils. Lancet 342:1348-1351.
    • (1993) Lancet , vol.342 , pp. 1348-1351
    • Ziegler, J.L.1
  • 23
    • 33847038019 scopus 로고    scopus 로고
    • Human herpesvirus 8 and iron staining are useful in differentiating Kaposi sarcoma from interstitial granuloma annulare
    • DOI 10.1309/GMH9CENH4909AWVB
    • Wada DA, Perkins SL, Tripp S, Coffin CM, Florell SR (2007) Human herpesvirus 8 and iron staining are useful in differentiating Kaposi sarcoma from interstitial granuloma annulare. Am J Clin Pathol 127:263-270. (Pubitemid 46797184)
    • (2007) American Journal of Clinical Pathology , vol.127 , Issue.2 , pp. 263-270
    • Wada, D.A.1    Perkins, S.L.2    Tripp, S.3    Coffin, C.M.4    Florell, S.R.5
  • 24
    • 0037093467 scopus 로고    scopus 로고
    • Ubiquitylation of MHC class I by the K3 viral protein signals internalization and TSG101-dependent degradation
    • Hewitt EW, et al. (2002) Ubiquitylation of MHC class I by the K3 viral protein signals internalization and TSG101-dependent degradation. EMBO J 21:2418-2429.
    • (2002) EMBO J , vol.21 , pp. 2418-2429
    • Hewitt, E.W.1
  • 25
    • 33646147146 scopus 로고    scopus 로고
    • Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules
    • Duncan LM, et al. (2006) Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules. EMBO J 25:1635-1645.
    • (2006) EMBO J , vol.25 , pp. 1635-1645
    • Duncan, L.M.1
  • 26
    • 73549090361 scopus 로고    scopus 로고
    • Efficient internalization of MHC I requires lysine-11 and lysine-63 mixed linkage polyubiquitin chains
    • Boname JM, et al. (2010) Efficient internalization of MHC I requires lysine-11 and lysine-63 mixed linkage polyubiquitin chains. Traffic 11:210-220.
    • (2010) Traffic , vol.11 , pp. 210-220
    • Boname, J.M.1
  • 27
    • 39149132089 scopus 로고    scopus 로고
    • ESCRT complexes and the biogenesis of multivesicular bodies
    • Hurley JH (2008) ESCRT complexes and the biogenesis of multivesicular bodies. Curr Opin Cell Biol 20:4-11.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 4-11
    • Hurley, J.H.1
  • 28
    • 2342640284 scopus 로고    scopus 로고
    • Membrane traffic: GGAs sort ubiquitin
    • Pelham HR (2004) Membrane traffic: GGAs sort ubiquitin. Curr Biol 14:R357-R359.
    • (2004) Curr Biol , vol.14
    • Pelham, H.R.1
  • 29
    • 33746361251 scopus 로고    scopus 로고
    • The role of iron regulatory proteins in mammalian iron homeostasis and disease
    • DOI 10.1038/nchembio807, PII NCHEMBIO807
    • Rouault TA (2006) The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nat Chem Biol 2:406-414. (Pubitemid 44114917)
    • (2006) Nature Chemical Biology , vol.2 , Issue.8 , pp. 406-414
    • Rouault, T.A.1
  • 30
    • 34247611854 scopus 로고    scopus 로고
    • Immune evasion by Kaposi's sarcoma-associated herpesvirus
    • Coscoy L (2007) Immune evasion by Kaposi's sarcoma-associated herpesvirus. Nat Rev Immunol 7:391-401.
    • (2007) Nat Rev Immunol , vol.7 , pp. 391-401
    • Coscoy, L.1
  • 31
    • 0033574075 scopus 로고    scopus 로고
    • Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum
    • Waheed A, et al. (1999) Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum. Proc Natl Acad Sci USA 96:1579-1584.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 1579-1584
    • Waheed, A.1
  • 33
    • 33746494909 scopus 로고    scopus 로고
    • Localisation of proteins of iron metabolism in the human placenta and liver
    • DOI 10.1111/j.1365-2141.2006.06216.x
    • Bastin J, Drakesmith H, Rees M, Sargent I, Townsend A (2006) Localisation of proteins of iron metabolism in the human placenta and liver. Br J Haematol 134:532-543. (Pubitemid 44141720)
    • (2006) British Journal of Haematology , vol.134 , Issue.5 , pp. 532-543
    • Bastin, J.1    Drakesmith, H.2    Rees, M.3    Sargent, I.4    Townsend, A.5
  • 34
    • 0036252492 scopus 로고    scopus 로고
    • High-level transduction and gene expression in hematopoietic repopulating cells using a human imunodeficiency virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter
    • DOI 10.1089/10430340252898984
    • Demaison C, et al. (2002) High-level transduction and gene expression in hematopoietic repopulating cells using a human immunodeficiency [correction of immunodeficiency] virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter. Hum Gene Ther 13:803-813. (Pubitemid 34493974)
    • (2002) Human Gene Therapy , vol.13 , Issue.7 , pp. 803-813
    • Demaison, C.1    Parsley, K.2    Brouns, G.3    Scherr, M.4    Battmer, K.5    Kinnon, C.6    Grez, M.7    Thrasher, A.J.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.